My five in no particular order are:

Nerdwriter https://www.youtube.com/channel/UCJkMlOu7faDgqh4PfzbpLdg
kaptainkristian https://www.youtube.com/channel/UCuPgdqQKpq4T4zeqmTelnFg
Kurzgesagt https://www.youtube.com/channel/UCsXVk37bltHxD1rDPwtNM8Q
exurb1a https://www.youtube.com/channel/UCimiUgDLbi6P17BdaCZpVbg
CGP Grey https://www.youtube.com/channel/UC2C_jShtL725hvbm1arSV9w

Damn.... they prob my top 5 too, but for the sake of difference

Game design stuff:
Extra Credits https://www.youtube.com/channel/UCCODtTcd5M1JavPCOr_Uydg
Errant Signal
https://www.youtube.com/channel/UCm4JnxTxtvItQecKUc4zRhQ

Movie stuff
Every Frame a Painting https://www.youtube.com/channel/UCjFqcJQXGZ6T6sxyFB-5i6A
Mr Sunday Movies https://www.youtube.com/channel/UCkDSAQ_5-yx5hmuvUcsJL7A

Politics:
Vox https://www.youtube.com/channel/UCLXo7UDZvByw2ixzpQCufnA

Ha, Every Frame a Painting was my sixth, but i thought choosing five was the proper number to go with.

I have too many to narrow down.

This week it has been:

• Wanted Adventure (for example https://youtu.be/wjQgjoZBjhI )
• Blancolirio (the name is spanish for white lily, Juan is a commercial pilot who has been covering the Oroville Dam debacle but it turns out his other videos are also really cool)
• Goodwood Road and Racing (Vroom!)
• Deep Look (and The Nature of Science) for nature videos from scientists.
• Arika Okrent (and also Langfocus) on linguistics
• Luna Lee (for example https://youtu.be/ANmvwQYRglw )

Here are my 5 favorite CAT channels on YT:

The Kits Cats - https://www.youtube.com/user/DrNworb

ScoobyHubby - https://www.youtube.com/user/ScoobyHubby

Furball Fables - https://www.youtube.com/user/Furballfables

Sho Ko - https://www.youtube.com/user/ShortyTheCat2010

klusmanp - https://www.youtube.com/user/klusmanp

America's Test Kitchen
Kirsten Dirksen
Mrs. Betty Bowers
Regular Cars
TED

Eric got most of mine, so I'll just add some extra:
Lessons from the Screenplay: https://www.youtube.com/channel/UCErSSa3CaP_GJxmFpdjG9Jw
Now you see it: https://www.youtube.com/channel/UCWTFGPpNQ0Ms6afXhaWDiRw
Channel Criswell: https://www.youtube.com/channel/UCL5kBJmBUVFLYBDiSiK1VDw
Rossatron: https://www.youtube.com/channel/UCxUR9wLuzgsvA6mpgKtiqGw
Alt Shift X: https://www.youtube.com/channel/UCveZqqGewoyPiacooywP5Ig
His drunk cousin: Alt Schwift X: https://www.youtube.com/channel/UC0r29hWF31MAwgfilNTUrbA
Casey Neistadt: https://www.youtube.com/channel/UCtinbF-Q-fVthA0qrFQTgXQ
Oliver Harper: https://www.youtube.com/channel/UC4zKSynEH_sLA1TC8_kU0gQ

I'm backing Oliver Harper and Alt Shift X on Patreon too, since I like them so much.