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Mr Scruff - Mice at The Organ has been added as a related post - related requested by Norsuelefantti.

~ fish ~ has been added as a related post - related requested by Norsuelefantti.

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Mr Scruff - Donkey Ride has been added as a related post - related requested by Norsuelefantti.

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*related=http://videosift.com/video/Mr-Scruff-Mice-at-The-Organ
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CBD possesses sedative properties (Carlini and Cunha, 1981), and a clinical
trial showed that it reduces the anxiety and other unpleasant psychological
side effects provoked by pure THC (Zuardi et al. 1982). CBD modulates the
pharmacokinetics of THC by three mechanisms: (1) it has a slight affinity for
cannabinoid receptors (Ki at CB1 = 4350 nM, compared to THC = 41 nM,
Showalter et al. 1996), and it signals receptors as an antagonist or reverse agonist
(Petitet et al. 1998), (2) CBD may modulate signal transduction by perturbing
the fluidity of neuronal membranes, or by remodeling G-proteins that
carry intracellular signals downstream from cannabinoid receptors, and (3)CBD
is a potent inhibitor of cytochrome P450 3A11 metabolism, thus it blocks the
hydroxylation of THC to its 11-hydroxy metabolite (Bornheim et al. 1995).
The 11-hydroxy metabolite is four times more psychoactive than unmetabolized
THC (Browne and Weissman 1981), and four times more immunosuppressive
(Klein et al. 1987).
CBD provides antipsychotic benefits (Zuardi et al. 1995). It increases dopamine
activity, serves as a serotonin uptake inhibitor, and enhances norepinephrine
activity (Banerjee et al. 1975; Poddar and Dewey 1980). CBD protects
neurons from glutamate toxicity and serves as an antioxidant, more potently
than ascorbate and α-tocopherol (Hampson et al. 1998). Auspiciously, CBD
does not decrease acetylcholine (ACh) activity in the brain (Domino 1976;
Cheney et al. 1981). THC, in contrast, reduces hippocampal ACh release in
rats (Carta et al. 1998), and this correlates with loss of short-term memory consolidation.
In the hippocampus THC also inhibits N-methyl-D-aspartate (NMDA)
receptor activity (Misner and Sullivan 1999; Shen and Thayer 1999), and
NMDA synaptic transmission is crucial for memory consolidation (Shimizu et
al. 2000). CBD, unlike THC, does not dampen the firing of hippocampal cells
(Heyser et al. 1993) and does not disrupt learning (Brodkin and Moerschbaecher
1997).
Consroe (1998) presented an excellent review of CBD in neurological disorders.
In some studies, it ameliorates symptoms of Huntington’s disease, such
as dystonia and dyskinesia. CBD mitigates other dystonic conditions, such as
torticollis, in rat studies and uncontrolled human studies. CBD functions as an
anticonvulsant in rats, on a par with phenytoin (Dilantin, a standard antiepileptic
drug).
CBD demonstrated a synergistic benefit in the reduction of intestinal motility
in mice produced by THC (Anderson, Jackson, and Chesher 1974). This
may be an important component of observed benefits of cannabis in inflammatory
bowel diseases.

--"Cannabis and Cannabis Extracts:
Greater Than the Sum of Their Parts?
John M. McPartland
Ethan B. Russo"

King of Tokyo, Zombicide, Escape, Mansions of Madness, BSG the Board Game, Mice and Mystics (great co-operative game), X-Wing Miniatures game, Android: Netrunner (perhaps best 2 player game out there), Arkham Horror are just a few of the better games on my board game shelf... want to try 7 Wonders and many others... I play Small World, Forbidden Island, Eclipse, Ascension, and Summoner Wars on my iPad
Catan is a decent game, and does well as a gateway (I think Ticket to Ride is better, and perhaps even Pandemic)...
Love board gaming...

I prefer FPS on the PC - using a joystick is just frustrating. But then again I couldn't imagine playing Little Big Planet on a PC. (although the Xbox 360 controller works great for many PC games, and it's nice that Steam is trying a joystick-friendly interface for big-tv-attached-PC-gaming.)

The thing I really hate is that both Xbox 360 and PS3 support USB keyboards and mice. It's completely up to the developers to include that in their game or not. I got a reply once from the makers of Resistance, and the reason they said they didn't include it was because it would make it unfair for multiplayer... well how about Single Player? or have a server setting that would allow/disallow keyboard+mouse?

Of course the entire universe is a quantum computer! When using the earth as one failed, the mice re-contracted to have the entire universe rebooted as one.
Of course, the answer is still 42.
(Douglas Adams)

He figured out that rats and mice tend to jump up onto warm engines. Smart bird. Unlucky bird... but still smart.

He must be seeing little mice scurrying about, just waiting for one to venture a little closer...liitttllle cloooossserrrrrrr

That's nothing, my cat makes threatening calls to mice she let go

"Oh look, it's those nice young men who like to feed me. Thanks for all the mouses!"





(Yes, I know, it's mice. But mouses sounded better.)

3 blind mice, 3 blind mice, see how they run, see how the run...

Not far and not for long as it turns out.

Tags for this video have been changed from 'Mice, Trap, Basement, Light, Commentary, Wait Fot It' to 'Mice, Trap, Basement, Light, Commentary, Wait For It' - edited by xxovercastxx

"Two points of entry with the lab-tested staircase design, lead mice into the shock and drop CHAMBERRR..!!"....This has to be one of the most impressive trade presentations since the OFF commercial with an arm in with mosquitos....