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Herbs And Empires: A Brief History Of Malaria Drugs

MilkmanDan says...

@Jinx - Cool -- I knew Thalassemia and Sickle Cell Anemia were similar, but I didn't know SCA granted similar malaria protection. Probably both are evolutionary responses to the disease (although "response" makes it sound like there was a conscious agent responsible).

I went to Africa with my folks when I was 4-5 years old. We all took quinine for the malaria protection, but it must have been pre-mixed with stuff to take the bitter edge off of it, like the honey did for yours. But I guess at 4-5 years old I still thought it was pretty suspect tasting -- my folks ended up telling me that it was "zebra milk" in order to get me to choke it down.

Herbs And Empires: A Brief History Of Malaria Drugs

Jinx says...

Sickle-Cell Anemia is similar with a slight twist. The disease is caused by a mutation of a gene for haemoglobin, which deforms and causes the red blood cells to take on a sickle shape. In the case of SCA the gene has more than one dominant allele, known as codominance (I think thats also why hair colours "mix", but dont quote me on that). As a result carriers of the disease have one copy of the mutated gene and one healthy copy. They produce healthy AND deformed sickle shaped red blood cells. Carriers with this heterozygous form are practically free from symptons of the full disease and while not immune to malaria they are more resistant. Strangely, and for reasons I dont fully understand, those with the full disease are still vulnerable to Malaria, or at least malaria makes the symptoms of SCA worse.

Unsurprisingly SCA is fairly common in parts of Africa where Malaria claims a lot of lives. It would be a pretty amazing adaption if it were not for the 25% chance that any child between two carriers suffered from the full disease.

Now for my somewhat related story:
I tried the "natural" Malaria remedy in Kenya. The Masai guide had this huge grin on his face when he offered it to me that in hindsight should have definitely tipped me off. I'm guessing it was quinene based because it was so bitter that I wretched it and a fair portion of my breakfast up and out on the spot. He made it up later when he found some wild honey (you know, as you do - Masai ftw) to take the taste away.

MilkmanDan said:

Interesting. I've got a semi-relevant story, but I get long winded so feel free to skip to the next comments if you like.

My wife (Thai) and I (American) had our first daughter this year. When she first got pregnant, one of the doc's first priorities was to get us both tested for "Thalassemia", which I had never heard of before. Apparently it is a blood disorder that affects hemoglobin production and therefore red blood cells -- if both parents carry the (rather rare) recessive gene, it can be a pretty bad deal.

It turned out that my wife is in the 1% or so of Thais that carry the gene (but she doesn't express / suffer from it, it is recessive and she has the dominant gene also). I had to get tested as well, but they said it would be incredibly unlikely that I'd be positive and I wasn't. So, our daughter has a 25% chance of being a carrier like my wife but zero chance of suffering from the effects of it.

Anyway, I was curious about the disease and asked the doc why it is a big deal here (every pregnant couple MUST get screened for it here when getting hospital/prenatal care) but I'd never even heard of it in the US. It turns out that the disease / genetic mutation arose only in places with high rates of malaria. As it happens, the genetic effect on your blood cells that the mutation has makes you more resistant to malaria -- full-on exhibitors of it (two recessive genes) are far less likely to die of malaria than people that don't have the gene. That is, assuming that you don't have the extreme variants of it that make it very unlikely to survive early childhood. Basically, if you have the disease and yet are healthy enough to survive to adulthood, you're close to malaria immune (that's overstating it, but ballpark). The malaria parasite can't survive and reproduce properly on your funky Thalassemia-affected red blood cells.

I thought that was a pretty interesting evolutionary response that must have arisen from some populations being pretty much decimated by malaria back in pre-recorded history. Current carriers like my wife are probably the descendants of lucky folks that survived a deadly outbreak in history by virtue of having a disease/mutation that is, under normal circumstances, slightly or even extremely bad in species survival / reproductive fitness terms. I thought that was kinda cool -- but I'm glad that neither my wife nor my daughter are/can be full-on expressors of the gene.

Herbs And Empires: A Brief History Of Malaria Drugs

MilkmanDan says...

Interesting. I've got a semi-relevant story, but I get long winded so feel free to skip to the next comments if you like.

My wife (Thai) and I (American) had our first daughter this year. When she first got pregnant, one of the doc's first priorities was to get us both tested for "Thalassemia", which I had never heard of before. Apparently it is a blood disorder that affects hemoglobin production and therefore red blood cells -- if both parents carry the (rather rare) recessive gene, it can be a pretty bad deal.

It turned out that my wife is in the 1% or so of Thais that carry the gene (but she doesn't express / suffer from it, it is recessive and she has the dominant gene also). I had to get tested as well, but they said it would be incredibly unlikely that I'd be positive and I wasn't. So, our daughter has a 25% chance of being a carrier like my wife but zero chance of suffering from the effects of it.

Anyway, I was curious about the disease and asked the doc why it is a big deal here (every pregnant couple MUST get screened for it here when getting hospital/prenatal care) but I'd never even heard of it in the US. It turns out that the disease / genetic mutation arose only in places with high rates of malaria. As it happens, the genetic effect on your blood cells that the mutation has makes you more resistant to malaria -- full-on exhibitors of it (two recessive genes) are far less likely to die of malaria than people that don't have the gene. That is, assuming that you don't have the extreme variants of it that make it very unlikely to survive early childhood. Basically, if you have the disease and yet are healthy enough to survive to adulthood, you're close to malaria immune (that's overstating it, but ballpark). The malaria parasite can't survive and reproduce properly on your funky Thalassemia-affected red blood cells.

I thought that was a pretty interesting evolutionary response that must have arisen from some populations being pretty much decimated by malaria back in pre-recorded history. Current carriers like my wife are probably the descendants of lucky folks that survived a deadly outbreak in history by virtue of having a disease/mutation that is, under normal circumstances, slightly or even extremely bad in species survival / reproductive fitness terms. I thought that was kinda cool -- but I'm glad that neither my wife nor my daughter are/can be full-on expressors of the gene.

You're not a scientist!

Thank You God - Tim Minchin

eric3579 says...

I have an apology to make
I'm afraid I've made a big mistake
I turned my face away from you, Lord

I was too blind to see the light
I was too meek to feel Your might
I closed my eyes; I couldn't see the truth, Lord

But then like Saul on the Damascus road,
You sent a messenger to me, and so
Now I've have had the truth revealed to me
Please forgive me all those things I said
I'll no longer betray you, Lord
I will pray to you instead

And I will say thank you, thank you
Thank you, God
Thank you, thank you
Thank you, God...

Thank you, God, for fixing the cataracts of Sam's mum
I had no idea, but it's suddenly so clear now
I feel such a cynic, how could I have been so dumb?
Thank you for displaying how praying works:
A particular prayer in a particular church
Thank you Sam for the chance to acknowledge this
Omnipotent ophthalmologist

Thank you, God, for fixing the cataracts of Sam's mum
I didn't realize that it was so simple
But you've shown a great example of just how it can be done
You only need to pray in a particular spot
To a particular version of a particular god,
And if you pull that off without a hitch,
He will fix one eye of one middle-class white bitch

I know in the past my outlook has been limited
I couldn't see examples of where life had been definitive
But I can admit it when the evidence is clear,
As clear as Sam's mum's new cornea
(And that's extremely clear! )

Thank you, God, for fixing the cataracts of Sam's mum
I have to admit that in the past I have been skeptical
But Sam described this miracle and I am overcome!
How fitting that the sighting of a sight-based intervention
Should open my eyes to this exciting new dimension
It's like someone put an eye chart up in front of me
And the top five letters say: I C, G O D

Thank you, Sam, for showing how my point of view has been so flawed
I assumed there was no God at all but now I see that's cynical
It's simply that his interests aren't particularly broad
He's largely undiverted by the starving masses,
Or the inequality between the various classes
He gives you strictly limited passes,
Redeemable for surgery or two-for-one glasses

I feel so shocking for historically mocking
Your interests are clearly confined to the ocular
I bet given the chance, you'd eschew the divine
And start a little business selling contacts online

Fuck me Sam, what are the odds
That of history's endless parade of gods
That the God you just happened to be taught to believe in
Is the actual one and he digs on healing,
But not the AIDS-ridden African nations
Nor the victims of the plague, nor the flood-addled Asians,
But healthy, privately-insured Australians
With common and curable corneal degeneration

This story of Sam's has but a single explanation:
A surgical God who digs on magic operations
No, it couldn't be mistaken attribution of causation
Born of a coincidental temporal correlation
Exacerbated by a general lack of education
Vis-a-vis physics in Sam's parish congregation
And it couldn't be that all these pious people are liars
It couldn't be an artefact of confirmation bias
A product of groupthink,
A mass delusion,
An Emperor's New Clothes-style fear of exclusion

No, it's more likely to be an all-powerful magician
Than the misdiagnosis of the initial condition,
Or one of many cases of spontaneous remission,
Or a record-keeping glitch by the local physician

No, the only explanation for Sam's mum's seeing:
They prayed to an all-knowing superbeing,
To the omnipresent master of the universe,
And he quite liked the sound of their muttered verse.

So for a bit of a change from his usual stunt
Of being a sexist, racist, murderous cunt
He popped down to Dandenong and just like that
Used his powers to heal the cataracts of Sam's mum
Of Sam's mum

Thank you God for fixing the cataracts of Sam's mum!
I didn't realize that it was such a simple thing
I feel such a dingaling, what ignorant scum!

Now I understand how prayer can work:
A particular prayer in a particular church
In a particular style with a particular stuff
And for particular problems that aren't particularly tough,
And for particular people, preferably white
And for particular senses, preferably sight
A particular prayer in a particular spot
To a particular version of a particular god

And if you get that right, he just might
Take a break from giving babies malaria
And pop down to your local area
To fix the cataracts of your mum!

Bill Gates jumping over a chair like a gangster

Louis CK - What Would You Do with 85 Billion?

gwiz665 says...

Once you get to that level, the things you can do escalate into global affairs. I mean, with millions I would just do all the good shit I want for myself, but once that's covered it would be incredible what you could do - feed all of africa, build infrastructure there, help impoverished countries, research into diseases like aids, malaria, catholicism. Restart the spaceprogram. Shit, your imagination would be the limiting factor.

Or maybe I'd just get like 100 hummers and some McMansions like a real american -_-

Home Video with Portals!

Malaria Parasite Invades Human Red Blood Cell

Mashiki says...

Oh look someone who doesn't understand that when you're testing new drugs, that you occasionally find something that does something else. Ever hear of Rogaine, that magical drug for hair loss recovery? Did you know it was originally a heart medication. So was viagra. I'm sure that understanding the differences between the two will be illuminating. Besides, killing microscopic parasites is hard, unless you want to kill the patient.

I'm sure it'll further amaze you that some of the immunoboosters used in cancer treatment are the class-a drugs for treating aids now.

>> ^wraith:

Oh look, someone with a "The Invisible Hand Of The Market will sheperd and protect us all" attitude!
(From wikipedia)
I don't know of a single death from Erectile Dysfunction that could have been prevented if Viagra would have been invented earlier.
>>

a message to all neocons who booed ron paul

ghark says...

That list of American crimes in the video is just the beginning, America's assassination of the democratically elected Prime Minister of Congo in 1960 and subsequent installation of a dictator (Mobutu) has led to countless millions of deaths. Just in the decade between 1998-2008 there were 5.4 million deaths from Malaria, diarrhea, pneumonia and malnutrition.

"Most of the deaths are due to easily treatable and preventable diseases through the collapse of health systems and the disruption of livelihoods,"

from http://www.reuters.com/article/2008/01/22/us-congo-democratic-death-idUSL2280201220080122

These figures also don't shed light on the fact that the Congo is the rape capital of the world, and the absolute greed of Mobutu (when he was alive) - "Besides what Mobutu siphoned off and stole, he paid himself generously. His personal salary was 17% of the state budget. By 1989, he officially received $100 million a year to spend as he wished, more than the government spent on education, health and social services combined."

http://articles.latimes.com/1997/sep/08/news/mn-30058

Here is a list of some other regime changes:
http://en.wikipedia.org/wiki/Covert_U.S._regime_change_actions

Why Are You Atheists So Angry? - Greta Christina

shinyblurry says...

People without good critical thinking skills can be misled to do stupid and harmful things (like voting for prop . Faith is synonymous with lack of critical thinking. Faith is a problem no matter how benign some of its practitioners currently are because they can more easily be misled by clergy, politicians, and hucksters.

Stupid people do stupid things, whether they are theists or atheists. Faith has nothing to do with it, and your idea that believing in a higher power is a suspension of critical thinking shows that you are intellectually satisfied with a stereotypical and superficial analysis, which itself shows a lack of critical thinking.

With over 90 percent of the world having some kind of faith in a higher power, and 93 percent of this country, you must think you're pretty darn special, considering that you must believe that the vast majority of people on this planet, and those who came before them, are inferior to you. Yet, you have more faith than anyone else. Here is a smart person to tell you about it:

atheism requires the greatest faith, as it demands that ones limited store of human knowledge is sufficient to exclude the possibility of God.

francis collins human genome project

Christian theology is bullshit because the problem of evil is insurmountable.

You apparently don't know the difference between the logical problem of evil and the evidential problem of evil. They are separate issues.



Malaria was not created by free will. If there were a benevolent all-powerful creator, he would not have allowed Malaria to exist.

What about poisonous mushrooms? Should He allow those? Someone might eat one. Should He have allowed us to invent electricity, since people have been electrocuted? How about hang nails? Long lines at the grocery store?

Sin fucked up the world? Well, the creator would have had to create the magic that would cause the world to become fucked up when sin occurred. Malaria is necessary for the greater good?

Man screwed up the world. Sickness, disease and death are the consequences of sin entering into the world through man. None of it was necessary, but God is still capable of using it to achieve a greater good.

You just have a very imbalanced view here. You blame God for the bad but fail to notice the good. If there is anyone to blame for scourge of Malaria today, it is the apathy of human beings:

http://health.howstuffworks.com/wellness/preventive-care/malaria-prevention.htm

That makes your supposed creator about as 'benevolent' as Hitler who thought gassing Jews was necessary for the greater good. The god of the old testament is a genocidal megalomaniac, exactly like Hitler.

Hitler didn't send his son to die on a cross for your sins. God has His hand extended to you to pull you out of the fire at any time, but it's on you to reach out for it.

>> ^jwray:

People without good critical thinking skills can be misled to do stupid and harmful things (like voting for prop . Faith is synonymous with lack of critical thinking. Faith is a problem no matter how benign some of its practitioners currently are because they can more easily be misled by clergy, politicians, and hucksters.
Christian theology is bullshit because the problem of evil is insurmountable.
Malaria was not created by free will. If there were a benevolent all-powerful creator, he would not have allowed Malaria to exist. Sin fucked up the world? Well, the creator would have had to create the magic that would cause the world to become fucked up when sin occurred. Malaria is necessary for the greater good? That makes your supposed creator about as 'benevolent' as Hitler who thought gassing Jews was necessary for the greater good. The god of the old testament is a genocidal megalomaniac, exactly like Hitler.
It is pretty fucked up to believe in / worship this bloodthirsty megalomaniac without any evidence that he even exists.
Yes, church gives you a sense of community. That's fine. I still even go to a church event once in a blue moon to catch up with some old friends from 10 years of attending the same small Sunday school classes. But for fuck's sake, there are other ways to meet people and serve your community than through glorifying a fictional genocidal tyrant who wouldn't even deserve it if the bible were true.

Why Are You Atheists So Angry? - Greta Christina

jwray says...

People without good critical thinking skills can be misled to do stupid and harmful things (like voting for prop . Faith is synonymous with lack of critical thinking. Faith is a problem no matter how benign some of its practitioners currently are because they can more easily be misled by clergy, politicians, and hucksters.

Christian theology is bullshit because the problem of evil is insurmountable.
Malaria was not created by free will. If there were a benevolent all-powerful creator, he would not have allowed Malaria to exist. Sin fucked up the world? Well, the creator would have had to create the magic that would cause the world to become fucked up when sin occurred. Malaria is necessary for the greater good? That makes your supposed creator about as 'benevolent' as Hitler who thought gassing Jews was necessary for the greater good. The god of the old testament is a genocidal megalomaniac, exactly like Hitler.

It is pretty fucked up to believe in / worship this bloodthirsty megalomaniac without any evidence that he even exists.

Yes, church gives you a sense of community. That's fine. I still even go to a church event once in a blue moon to catch up with some old friends from 10 years of attending the same small Sunday school classes. But for fuck's sake, there are other ways to meet people and serve your community than through glorifying a fictional genocidal tyrant who wouldn't even deserve it if the bible were true.

Since Evil & Suffering Exist, A Loving God Cannot ...?

Bill Nye Explaining Science on Fox is "Confusing Viewers"

BicycleRepairMan says...

The point about global warming is that all the available evidence shows that:
1. It is happening
2. It is man-made.

Why is that a problem? well, because we dont know what the consequences could be, we dont know how to stop the rising temperature or if theres a limit or if or when we can reverse the trend.

All of the above could happen, or it might not, some of it may not be due to GW and some of it may be. The fact is that we are messing with earths ecosystem, which is the very reason we are here in the first place. We grew up and evolved as a species on this planet, under these conditions, how will a rapid(geologically rapid 100-200 years) change in climate affect us as a species? how will it affect millions of other species? How will it affect weather? viruses? diseases? deserts? forests?

We don't know

Thats the point. some of the above are possible consequences of global warming*.

*or some denialist pulled it out of their ass and put it on the web so that other denialists could impress us all with their extensive lists.

>> ^quantumushroom:

Enviro-statist alarmists claim that all of the following have been (or will be) caused by global warming.

Agricultural land increase, Africa devastated, African aid threatened, air pressure changes, Alaska reshaped, allergies increase, Alps melting, Amazon a desert, American dream end, amphibians breeding earlier (or not), ancient forests dramatically changed, Antarctic grass flourishes, anxiety, algal blooms, Arctic bogs melt, Asthma, atmospheric defiance, atmospheric circulation modified, avalanches reduced, avalanches increased, bananas destroyed, bananas grow, better beer, big melt faster, billion dollar research projects, billions of deaths, bird distributions change, birds return early, blackbirds stop singing, blizzards, blue mussels return, boredom, Britain Siberian, British gardens change, bubonic plague, budget increases, building season extension, bushfires, business opportunities, business risks, butterflies move north.
Cardiac arrest, caterpillar biomass shift, challenges and opportunities, Cholera, civil unrest, cloud increase, cloud stripping, cod go south, cold climate creatures survive, cold spells (Australia), computer models, conferences, coral bleaching, coral reefs dying, coral reefs grow, coral reefs shrink , cold spells, cost of trillions, crumbling roads, buildings and sewage systems, cyclones (Australia), damages equivalent to $200 billion, Dengue hemorrhagic fever, dermatitis, desert advance, desert life threatened, desert retreat, destruction of the environment, diarrhoea, disappearance of coastal cities, diseases move north, Dolomites collapse, drought, drowning people, ducks and geese decline, dust bowl in the corn belt.
Early spring, earlier pollen season, Earth biodiversity crisis, Earth dying, Earth even hotter, Earth light dimming, Earth lopsided, Earth melting, Earth morbid fever, Earth on fast track, Earth past point of no return, Earth slowing down, Earth spinning out of control, Earth to explode, earth upside down, Earth wobbling, earthquakes, El NiZo intensification, erosion, emerging infections, encephalitis, Europe simultaneously baking and freezing, evolution accelerating, expansion of university climate groups, extinctions (human, civilisation, logic, Inuit, smallest butterfly, cod, ladybirds, bats, pandas, pikas, polar bears, pigmy possums, gorillas, koalas, walrus, whales, frogs, toads, turtles, orang-utan, elephants, tigers, plants, salmon, trout, wild flowers, woodlice, penguins, a million species, half of all animal and plant species, less, not polar bears), experts muzzled, extreme changes to California.
Famine, farmers go under, figurehead sacked, fish catches drop, fish catches rise, fish stocks decline, five million illnesses, floods, Florida economic decline, food poisoning, food prices rise, food security threat (SA), footpath erosion, forest decline, forest expansion, frosts, fungi invasion, Garden of Eden wilts, genetic diversity decline, gene pools slashed, glacial retreat, glacial growth, glacier wrapped, global cooling, global dimming, glowing clouds, Gore omnipresence, grandstanding, grasslands wetter, Great Barrier Reef 95% dead, Great Lakes drop, greening of the North, Gulf Stream failure, habitat loss, Hantavirus pulmonary syndrome, harvest increase, harvest shrinkage, hay fever epidemic, hazardous waste sites breached, heat waves, hibernation ends too soon, hibernation ends too late, high court debates, human fertility reduced, human health improvement, human health risk, hurricanes, hydropower problems, hyperthermia deaths.
Ice sheet growth, ice sheet shrinkage, inclement weather, infrastructure failure (Canada), Inuit displacement, Inuit poisoned, Inuit suing, industry threatened, infectious diseases, insurance premium rises, invasion of midges, island disappears, islands sinking, itchier poison ivy, jellyfish explosion, Kew Gardens taxed, krill decline, lake and stream productivity decline, landslides, landslides of ice at 140 mph, lawsuits increase, lawsuit successful, lawyers’ income increased (surprise, surprise!), lightning related insurance claims, little response in the atmosphere, Lyme disease.
Malaria, malnutrition, Maple syrup shortage, marine diseases, marine food chain decimated, marine dead zone, Meaching (end of the world), megacryometeors, Melanoma, methane emissions from plants, methane burps, melting permafrost, Middle Kingdom convulses, migration, migration difficult (birds), microbes to decompose soil carbon more rapidly, more bad air days, more research needed, mountain (Everest) shrinking, mountains break up, mountains taller, mudslides, next ice age, Nile delta damaged, no effect in India, nuclear plants bloom, oaks move north, ocean acidification, outdoor hockey threatened, oyster diseases, ozone loss, ozone repair slowed, ozone rise.
Pacific dead zone, personal carbon rationing, pest outbreaks, pests increase, phenology shifts, plankton blooms, plankton destabilised, plankton loss, plant viruses, plants march north, polar bears aggressive, polar bears cannibalistic, polar bears drowning, polar bears starve, polar tours scrapped, psychosocial disturbances, railroad tracks deformed, rainfall increase, rainfall reduction, refugees, reindeer larger, release of ancient frozen viruses, resorts disappear, rice yields crash, rift on Capitol Hill, rioting and nuclear war, rivers raised, rivers dry up, rockfalls, rocky peaks crack apart, roof of the world a desert, Ross river disease.
Salinity reduction, salinity increase, Salmonella, salmon stronger, sea level rise, sea level rise faster, sex change, sharks booming, shrinking ponds, ski resorts threatened, slow death, smog, snowfall increase, snowfall reduction, societal collapse, songbirds change eating habits, sour grapes, spiders invade Scotland, squid population explosion, squirrels reproduce earlier, spectacular orchids, stormwater drains stressed.
Taxes, tectonic plate movement, terrorism, ticks move northward (Sweden), tides rise, tourism increase, trade winds weakened, tree beetle attacks, tree foliage increase (UK), tree growth slowed, trees could return to Antarctic, trees less colourful, trees more colourful, tropics expansion, tropopause raised, tsunamis, turtles lay earlier, UK Katrina, Venice flooded, volcanic eruptions.
Walrus pups orphaned, war, wars over water, water bills double, water supply unreliability, water scarcity (20% of increase), water stress, weather out of its mind, weather patterns awry, weeds, Western aid cancelled out, West Nile fever, whales move north, wheat yields crushed in Australia, white Christmas dream ends, wildfires, wind shift, wind reduced, wine - harm to Australian industry, wine industry damage (California), wine industry disaster (US), wine - more English, wine -German boon, wine - no more French , winters in Britain colder, wolves eat more moose, wolves eat less, workers laid off, World bankruptcy, World in crisis, Yellow fever.

Bill Nye Explaining Science on Fox is "Confusing Viewers"

quantumushroom says...

Enviro-statist alarmists claim that all of the following have been (or will be) caused by global warming.


Agricultural land increase, Africa devastated, African aid threatened, air pressure changes, Alaska reshaped, allergies increase, Alps melting, Amazon a desert, American dream end, amphibians breeding earlier (or not), ancient forests dramatically changed, Antarctic grass flourishes, anxiety, algal blooms, Arctic bogs melt, Asthma, atmospheric defiance, atmospheric circulation modified, avalanches reduced, avalanches increased, bananas destroyed, bananas grow, better beer, big melt faster, billion dollar research projects, billions of deaths, bird distributions change, birds return early, blackbirds stop singing, blizzards, blue mussels return, boredom, Britain Siberian, British gardens change, bubonic plague, budget increases, building season extension, bushfires, business opportunities, business risks, butterflies move north.

Cardiac arrest, caterpillar biomass shift, challenges and opportunities, Cholera, civil unrest, cloud increase, cloud stripping, cod go south, cold climate creatures survive, cold spells (Australia), computer models, conferences, coral bleaching, coral reefs dying, coral reefs grow, coral reefs shrink , cold spells, cost of trillions, crumbling roads, buildings and sewage systems, cyclones (Australia), damages equivalent to $200 billion, Dengue hemorrhagic fever, dermatitis, desert advance, desert life threatened, desert retreat, destruction of the environment, diarrhoea, disappearance of coastal cities, diseases move north, Dolomites collapse, drought, drowning people, ducks and geese decline, dust bowl in the corn belt.

Early spring, earlier pollen season, Earth biodiversity crisis, Earth dying, Earth even hotter, Earth light dimming, Earth lopsided, Earth melting, Earth morbid fever, Earth on fast track, Earth past point of no return, Earth slowing down, Earth spinning out of control, Earth to explode, earth upside down, Earth wobbling, earthquakes, El NiZo intensification, erosion, emerging infections, encephalitis, Europe simultaneously baking and freezing, evolution accelerating, expansion of university climate groups, extinctions (human, civilisation, logic, Inuit, smallest butterfly, cod, ladybirds, bats, pandas, pikas, polar bears, pigmy possums, gorillas, koalas, walrus, whales, frogs, toads, turtles, orang-utan, elephants, tigers, plants, salmon, trout, wild flowers, woodlice, penguins, a million species, half of all animal and plant species, less, not polar bears), experts muzzled, extreme changes to California.

Famine, farmers go under, figurehead sacked, fish catches drop, fish catches rise, fish stocks decline, five million illnesses, floods, Florida economic decline, food poisoning, food prices rise, food security threat (SA), footpath erosion, forest decline, forest expansion, frosts, fungi invasion, Garden of Eden wilts, genetic diversity decline, gene pools slashed, glacial retreat, glacial growth, glacier wrapped, global cooling, global dimming, glowing clouds, Gore omnipresence, grandstanding, grasslands wetter, Great Barrier Reef 95% dead, Great Lakes drop, greening of the North, Gulf Stream failure, habitat loss, Hantavirus pulmonary syndrome, harvest increase, harvest shrinkage, hay fever epidemic, hazardous waste sites breached, heat waves, hibernation ends too soon, hibernation ends too late, high court debates, human fertility reduced, human health improvement, human health risk, hurricanes, hydropower problems, hyperthermia deaths.

Ice sheet growth, ice sheet shrinkage, inclement weather, infrastructure failure (Canada), Inuit displacement, Inuit poisoned, Inuit suing, industry threatened, infectious diseases, insurance premium rises, invasion of midges, island disappears, islands sinking, itchier poison ivy, jellyfish explosion, Kew Gardens taxed, krill decline, lake and stream productivity decline, landslides, landslides of ice at 140 mph, lawsuits increase, lawsuit successful, lawyers’ income increased (surprise, surprise!), lightning related insurance claims, little response in the atmosphere, Lyme disease.

Malaria, malnutrition, Maple syrup shortage, marine diseases, marine food chain decimated, marine dead zone, Meaching (end of the world), megacryometeors, Melanoma, methane emissions from plants, methane burps, melting permafrost, Middle Kingdom convulses, migration, migration difficult (birds), microbes to decompose soil carbon more rapidly, more bad air days, more research needed, mountain (Everest) shrinking, mountains break up, mountains taller, mudslides, next ice age, Nile delta damaged, no effect in India, nuclear plants bloom, oaks move north, ocean acidification, outdoor hockey threatened, oyster diseases, ozone loss, ozone repair slowed, ozone rise.

Pacific dead zone, personal carbon rationing, pest outbreaks, pests increase, phenology shifts, plankton blooms, plankton destabilised, plankton loss, plant viruses, plants march north, polar bears aggressive, polar bears cannibalistic, polar bears drowning, polar bears starve, polar tours scrapped, psychosocial disturbances, railroad tracks deformed, rainfall increase, rainfall reduction, refugees, reindeer larger, release of ancient frozen viruses, resorts disappear, rice yields crash, rift on Capitol Hill, rioting and nuclear war, rivers raised, rivers dry up, rockfalls, rocky peaks crack apart, roof of the world a desert, Ross river disease.

Salinity reduction, salinity increase, Salmonella, salmon stronger, sea level rise, sea level rise faster, sex change, sharks booming, shrinking ponds, ski resorts threatened, slow death, smog, snowfall increase, snowfall reduction, societal collapse, songbirds change eating habits, sour grapes, spiders invade Scotland, squid population explosion, squirrels reproduce earlier, spectacular orchids, stormwater drains stressed.

Taxes, tectonic plate movement, terrorism, ticks move northward (Sweden), tides rise, tourism increase, trade winds weakened, tree beetle attacks, tree foliage increase (UK), tree growth slowed, trees could return to Antarctic, trees less colourful, trees more colourful, tropics expansion, tropopause raised, tsunamis, turtles lay earlier, UK Katrina, Venice flooded, volcanic eruptions.

Walrus pups orphaned, war, wars over water, water bills double, water supply unreliability, water scarcity (20% of increase), water stress, weather out of its mind, weather patterns awry, weeds, Western aid cancelled out, West Nile fever, whales move north, wheat yields crushed in Australia, white Christmas dream ends, wildfires, wind shift, wind reduced, wine - harm to Australian industry, wine industry damage (California), wine industry disaster (US), wine - more English, wine -German boon, wine - no more French , winters in Britain colder, wolves eat more moose, wolves eat less, workers laid off, World bankruptcy, World in crisis, Yellow fever.



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