According to Wikipedia, http://en.wikipedia.org/wiki/Lucia_di_Lammermoor#Trivia, it's been used in;

The "Lucia Sextet" (Chi mi frena in tal momento?) was recorded in 1908 by Enrico Caruso, Marcella Sembrich, Antonio Scotti, Marcel Journet, Barbara Severina, and Francesco Daddi, (Victor single-sided 70036) and released at the price of $7.00, earning it the title of "The Seven-Dollar Sextet". The film The Great Caruso incorporates a scene featuring a performance of this sextet.

The "Lucia Sextet" melody is best known to some from its use by the American slapstick comedy team the Three Stooges in their short films Micro-Phonies and Squareheads of the Round Table, sung in the latter with the lyrics "Oh, Elaine, can you come out tonight...." But the melody is used most dramatically in Howard Hawks' gangster classic "Scarface": Tony Camonte (Paul Muni) whistles "Chi mi frena?" in the film's opening sequence, as he guns down a ganglord boss he has been assigned to protect.

It has also been used in Warner Brothers cartoons: Long-Haired Hare, sung by the opera singer (Bugs Bunny's antagonist); Book Revue, sung by the wolf antagonist; and in Back Alley Oproar, sung by a choir full of Sylvesters, the cat.

The "Lucia Sextet" melody also figures in two scenes from the 2006 film The Departed, directed by Martin Scorsese. In one scene, Jack Nicholson's character is shown at a performance of "Lucia di Lammermoor", and the music on the soundtrack is from the sextet. Later in the film, Nicholson's cell phone ringtone is the sextet melody.

The Sextet is also featured during a scene from the 1986 comedy film, The Money Pit.

In the children's book "The Cricket in Times Square," Chester Cricket chirps the tenor part to the "Lucia Sextet" as the encore to his farewell concert, literally stopping traffic in the process.

An aria from the "mad scene," "Il dolce suono" (from the 3rd Act), was re-popularized when it was featured in the film The Fifth Element in a performance by the alien diva Plavalaguna (voiced by Albanian soprano Inva Mula-Tchako and played onscreen by French actress Maïwenn Le Besco). A loose remake of this film version of the song was covered by Russian pop singer Vitas.

The "mad scene" was also used in the first episode of the anime series Gankutsuou (in place of L'Italiana in Algeri which was the opera used in that scene in The Count of Monte Cristo).

The "mad scene" aria, as sung by Inva Mula-Tchako, was used in an episode of Law & Order: Criminal Intent involving the murder of a young violinist by her opera singer mother (who performs the song right after the murder).

The "mad scene" was released as a music video by Russian male soprano Vitas in 2006.

Among other selections from the opera, the "mad scene", "Verranno a te sull'aure", and "Che facesti?" feature prominently in the 1983 Paul Cox film Man of Flowers, especially "Verranno a te sull'aure," which accompanies a striptease in the film's opening scene.

The opera is mentioned in the novels The Count of Monte Cristo, Madame Bovary and Where Angels Fear to Tread and was reputedly one of Tolstoy's favorites.

"Regnava nel silenzio" accompanies the scene in Beetlejuice in which Lydia (Winona Ryder) composes a suicide note.

A portion of the opera is also used in a key scene of the film The Fifth Element, written and directed by Luc Besson.

I have hig hopes for Brütal Legend. It's made by the same developer that did Psychonauts, which unfortunately I haven't played but almost everybody that has say it's one of the best games ever. So Brütal Legend must be good right?

As for World of Goo, that video you linked to just got me interested in that game. I think I'll download the demo too.

It looks like there are many "small" games coming out these days that look really interesting. If anybody has an Xbox 360 I recommend that you check out Braid on xbox live arcade, it's a really good game. The official site of the game says there is a PC version planned but there is no release date on it yet.
Yesterday I saw a trailer for a game called Trine which also looks interesting.

yipyipyipyipyipyipyipyipyip dig-i-tal cam-er-a yipyipyipyipyipyipyip

Upvote for casting elmo as the parasites.

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I also love TAL. I love Deano too. But this playlist confuses the hell out of me.

E: oh, all the YT videos are doing that now. How distracting. Nefermiiind.

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Psychonauts is freakin' awesome. Though the last two levels are insanely annoying. One being a crazy "you have to jump here, then here, then here NO HERE!" kind of level.

Full Throttle was also really good, but I haven't had the chance to play Grim Fandango. Maybe Shafer's next game will satisfy the "twitch" crowd. It's called Brütal Legend and seems to kinda be a cross between Black & White, GTA, and Guitar Hero. Either way, it will be quite violent.