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How Not to Do Brownies

newtboy says...

Yes, and no.
Psychedelic, sure. Total ego death infinite out of body experience, nothing close.
Edibles, smoking flowers, smoking or eating concentrates, no. Trust me, I've tried. ;-)
There's a huge difference between somewhat psychedelic and his description. HUGE.
Is it possible, probably yes, but imo only if he's extraordinarily susceptible to thc (or another cannabinoid)or psychotic episodes (which I think I read can be triggered by marijuana).
It's far more likely if the story is true that he unintentionally took lsd, pcp, or some other long lasting psychedelic (I think dmt wears off too quickly to include it).

Engels said:

Newtboy, are you telling me you've never met anyone first hand that has had a psychedelic-type experience on edibles or just plain smoking flowers? Because although rare, it's still a thing. I've had some, very close to what this guy describes, and a friend of mine has them routinely. Are they strictly speaking hallucinations like under a psychotic episode? Not in my case, since the 'visualization' was in my mind's eye, and I wasn't literally seeing something appear in front of me, but it was psychedelic nonetheless.

All Your Burning Questions About Weed, Answered

Brittany Maynard - Death with Dignity

ChaosEngine says...

Yeah, 'cos I'm sure she and her family just gave up immediately....

Once again, there is no solid evidence that cannabis cures cancer. There are a number of promising studies that show that cannabinoids might inhibit tumour growth, but that's a world away from "curing cancer".

kennygourley said:

“I wish there was a cure for my disease, but there's not."

Hmmm if only she knew...

Cannabis Oil Cures Lung & Brain Cancer: The Stan Rutner Story:

https://www.youtube.com/watch?v=hT8ryvvdSto

Brittany Maynard - Death with Dignity

ChaosEngine says...

Actually you said

Cannabis cures cancer. To HELL with western medicine.


Then you posted a bunch of anecdotes from a hemp oil salesman.

Then you talked about Dr Marcia Angell; I presume that's the same Marica Angell that said
It is time for the scientific community to stop giving alternative medicine a free ride... There cannot be two kinds of medicine — conventional and alternative. There is only medicine that has been adequately tested and medicine that has not, medicine that works and medicine that may or may not work. Once a treatment has been tested rigorously, it no longer matters whether it was considered alternative at the outset. If it is found to be reasonably safe and effective, it will be accepted.


and finally a bunch of studies that show that cannabis may affect cancer.

None of which implies that "cannabis cures cancer" (again, your own words).

Cannabinoids certainly have some interesting properties that might well lead to some breakthroughs, but right now, NOTHING cures cancer. As you said, it gets cut, burnt or poisoned (all of which is preferable to dying), or it just goes into remission.

As for your general distain for "western medicine" aka medicine, you continue on with your fairy dust and good wishes. Me, I'll be over here with the scientific method and the single most successful endeavour in the history of humanity.

Sniper007 said:

TONS of things cure cancer. All day, every day. Doctors have no clue what cancer is. All they can do is cut, burn, or poison and cross their fingers.

I didn't say Cannabis was THE cure. It is A cure used by thousands with amazing efficacy. Everyone is different.

Brittany Maynard - Death with Dignity

Sniper007 says...

TONS of things cure cancer. All day, every day. Doctors have no clue what cancer is. All they can do is cut, burn, or poison and cross their fingers.

I didn't say Cannabis was THE cure. It is A cure used by thousands with amazing efficacy. Everyone is different.

Here's 60+ studies for your perusal if you insist on the superiority of western scientific research:

"Cannabis, and the cannabinoid compounds found within it, has been shown through a large cannabisplantamount of scientific, peer-reviewed research to be effective at treating a wide variety of cancers, ranging from brain cancer to colon cancer. Below is a list of over 60 studies that demonstrate the vast anti-cancer properties of cannabis.
Studies showing cannabis may combat brain cancer:
Cannabidiol (CBD) inhibits the proliferation and invasion in U87-MG and T98G glioma cells. Study published in the Public Library of Science journal in October 2013.
Tetrahydrocannabinol (THC) can kill cancer cells by causing them to self-digest. Study published in the Journal of Clinical Investigation in September 2013.
CBD is a novel therapeutic target against glioblastoma. Study published in Cancer Research in March 2013.
Local delivery of cannabinoid-filled microparticles inhibits tumor growth in a model of glioblastoma multiforme. Study published in Public Library of Science in January 2013.
Cannabinoid action inhibits the growth of malignant human glioma U87MG cells. Study published in Oncology Reports in July 2012.
Cannabidiol enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival. Study published in the Molecular Cancer Therapeutics journal in January 2010.
Cannabinoid action induces autophagy-mediated cell death in human glioma cells. Study published in The Journal of Clinical Investigation in May 2009.
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Study published in Cancer Research in March 2008.
Cannabinoids and gliomas. Study published in Molecular Neurobiology in June 2007.
Cannabinoids inhibit gliomagenesis. Study published in the Journal of Biological Chemistry in March 2007.
A pilot clinical study of THC in patients with recurrent glioblastoma multiforme. The results were published in the British Journal of Cancer in June 2006.
Cannabidiol inhibits human glioma cell migration through an independent cannabinoid receptor mechanism. Study published in the British Journal of Pharmacology in April 2005.
Cannabinoids inhibit the vascular endothelial growth factor pathway (VEGF) in gliomas. Study published in the Journal of Cancer Research in August 2004.
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. Study published in the Journal of Pharmacology in November 2003.
Inhibition of glioma growth in vivo by selective activation of the CB2 cannabinoid receptor. Study published in the Journal of Cancer Research in August 2001.
Studies showing cannabis may combat colorectal cancer:
Cannabigerol (CBG) can inhibit colon cancer cells. Study published in the Oxford journal Carcinogenesis in October 2014.
Inhibition of colon carcinogenesis by a standardised Cannabis Sativa extract with high content of CBD. Study published in Phytomedecine in December 2013.
Chemopreventive effect of the non-psychotropic phytocannabinoid CBD on colon cancer. Study published in the Journal of Molecular Medecine in August 2012.
Cannabinoids against intestinal inflammation and cancer. Study published in Pharmacology Research in August 2009.
Action of cannabinoid receptors on colorectal tumor growth. Study published by the Cancer Center of the University of Texas in July 2008.
Studies showing cannabis may combat blood cancer:
The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. Study published in the International Journal of Cancer in December 2013.
Enhancing the activity of CBD and other cannabinoids against leukaemia. Study published in Anticancer Research in October 2013.
Cannabis extract treatment for terminal acute lymphoblastic leukemia of Philadelphia chromosome (Ph1). Study published in Case Reports in Oncology in September 2013.
Expression of type 1 and type 2 cannabinoid receptors in lymphoma. Study published in the International Journal of Cancer in June 2008.
Cannabinoid action in mantle cell lymphoma. Study published in Molecular Pharmacology in November 2006.
THC-induced apoptosis in Jurkat leukemia. Study published in Molecular Cancer Research in August 2006.
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Study published in Blood American Society of Hemmatology in July 2002.
Studies showing cannabis can combat lung cancer:
Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of Icam-1. Study published in Biochemical Pharmacology in July 2014.
Cannabinoids inhibit angiogenic capacities of endothelial cells via release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells. Study published in Biochemical Pharmacology in June 2014.
COX-2 and PPAR-γ confer CBD-induced apoptosis of human lung cancer cells. Study published in Molecular Cancer Therapeutics in January 2013.
CBD inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. Study published in the Journal of the Federation of American Societies for Experimental Biology in April 2012.
Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non–small cell lung cancer growth and metastasis. Study published in Cancer Prevention Research in January 2011.
THC inhibits epithelial growth factor-induced (EGF) lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Study published in the journal Oncogene in July 2007.
Studies showing cannabis may combat stomach cancer:
Cannabinoid receptor agonist as an alternative drug in 5-Fluorouracil-resistant gastric cancer cells. Study published in Anticancer Research in June 2013.
Antiproliferative mechanism of a cannabinoid agonist by cell cycle arrest in human gastric cancer cells. Study published in the Journal of Cellular Biochemistry in March 2011.
Studies showing cannabis may combat prostrate cancer:
Cannabinoids can treat prostate cancer. Study published by the National Institute of Health in October 2013.
Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms. Study published in the British Journal of Pharmacology in December 2012.
The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications. Study published in the Indian Journal of Urology in January 2012.
Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent. Study published in Anticancer Research in November 2011.
Studies showing cannabis may combat liver cancer:
Involvement of PPARγ in the antitumoral action of cannabinoids on hepatocellular carcinoma (CHC). Study published in Cell Death and Disease in May 2013.
Evaluation of anti-invasion effect of cannabinoids on human hepatocarcinoma cells. Study published on the site Informa Healthcare in February 2013.
Antitumoral action of cannabinoids on hepatocellular carcinoma. Study published in Cell Death and Differentiation in April 2011.
Studies showing cannabis may combat pancreatic cancer:
Cannabinoids inhibit energetic metabolism and induce autophagy in pancreatic cancer cells. Study published in Cell Death and Disease in June 2013.
Cannabinoids Induce apoptosis of pancreatic tumor cells. Study published in Cancer Research in July 2006.
Studies showing cannabis may combat skin cancer:
Cannabinoid receptor activiation can combat skin cancer. Study published by the National Institute of Health in October 2013.
Cannabinoids were found to reduce skin cancer by 90% in just 2 weeks. Study published in the Journal of Pharmacy and Pharmacology in July 2013.
Cannabinoid receptors as novel targets for the treatment of melanoma. Study published in the Journal of the Federation of American Societies for Experimental Biology in December 2006.
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. Study published in the Journal of Clinical Investigation, in January 2003.
Studies showing cannabis may combat other types of cancer:
Bladder: Marijuana reduces the risk of bladder cancer. Study published in the Medscape site in May 2013.
Kaposi sarcoma: Cannabidiol inhibits growth and induces programmed cell death in Kaposi sarcoma–associated herpesvirus-infected endothelium. Study published in the journal Genes & Cancer in July 2012.
Nose, mouth, throat, ear: Cannabinoids like THC inhibit cellular respiration of human oral cancer cells. Study by the Department of Pediatrics at the State University of New York, published in June 2010.
Bile duct: The dual effects of THC on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration. Study published in Cancer Investigation in May 2010.
Ovaries: Cannabinoid receptors as a target for therapy of ovarian cancer. Study published on the American Association for Cancer Research website in 2006.
Preparation and characterisation of biodegradable microparticles filled with THC and their antitumor efficacy on cancer cell lines. Study published in the Journal of Drug Targeting in September 2013.
CBD Cannabidiol as a potential anticancer drug. Study published in the British Journal of Pharmacology in February 2013.
Cannabinoids as anticancer modulators. Study published in the Progress in Lipid Research journal in January 2013.
CBD inhibits angiogenesis by multiple mechanisms. Study published in the British Journal of Pharmacology in November 2012.
Towards the use of cannabinoids as antitumour agents. Study published in Nature in June 2012.
Cannabinoid-associated cell death mechanisms in tumor models. Study published in the International Journal of Oncology in May 2012.
Cannabinoids, endocannabinoids and cancer. Study published in Cancer Metastasis Reviews in December 2011.
The endocannabinoid system and cancer: therapeutic implication. Study published in the British Journal of Pharmacology in July 2011.
This list was compiled in part by Alchimiaweb.com.
– TheJointBlog"

ChaosEngine said:

No, you'd be remiss if you opined blatant misinformation.

While there is a possibility that cannabinoids can inhibit tumour growth, there is nothing even close to a solid evidence base to show that "cannabis cures cancer".

Brittany Maynard - Death with Dignity

Girl Banned from School for Supporting Friend with Cancer

enoch says...

why does everybody get their panties in a bunch when someone offers an alternative to dealing with cancers?

cancer treatment is NOT a black and white issue.
a change in diet as @Sniper007 suggested has been proven more and more to not only combat certain cancers but eliminate them altogether.

of course this course of treatment is a multi pronged attack and really only works in early diagnosis stages.
cannabinoid research over the past decade shows serious promise in reducing risks of cancer and reduction in overall cancer cell production in the body.

since many people here in the states do not have comprehensive,preventative health insurance the cancer is discovered far too late for some of what @Sniper007 is suggesting.

so chemotherapy is a last option.
and for those who do not understand why some here are calling chemotherapy "barbaric",let me clarify:

it is a controlled poisoning.
aaaaaaaand they are OFF!
who will die first?
is it the tumor or the body?

early diagnosis is the key but even in the latter stages cannabis can help eleviate pain and discomfort,as @Shepppard pointed out.

Contact High ... Yeah Right

chingalera says...

One of your problems with relying on published medical reports as the go-to source for medical education is the nature of the beast and her supporting interests (pharma companies, corporate HR concerns) and another is the success or failure of bi-polar self-medication with various chemical cocktails of choice from first-hand experience with sufferers. Depending on the severity of an individual's diagnosed level of manic-depression, some are able to cope just fine with what has always worked, as long as addiction or excess is kept in personal check according to the influence they have in their interpersonal relationships to society.

Have had plenty of friends who were able to cope just fine, others who let themselves go-MOST, have preferred self-medication over the doctor/guinea-pig relationship, but as more data is accumulated and more walking lab subjects are used in experimentation, they'll get better and better or so you'd like believe, as the gods-little-g of the Babylonian medical experiment put more and more problem herd animals into their respective categories and cages of dependency.

Cannabinoids DO work their wonders for bi-polars. As with ALL sufferers of brain chemistry problems, support from loved ones is key.

artician said:

I find it odd that she was given Medicinal use of pot when she is Bipolar, because as I have understood for some time, marijuana makes symptoms of psychosis much, much worse, and regular use for anyone who experiences Bipolar, Depression, Mania and the like can see their disease transform into full-blown Schizophrenia from pot use. Is that not true and I just fell for some anti-pot propaganda? This was from several medical reports published sometime in the last 5-10 years.

Dr Sanjay Gupta's CNN Special "WEED"

vaire2ube says...

CBD possesses sedative properties (Carlini and Cunha, 1981), and a clinical
trial showed that it reduces the anxiety and other unpleasant psychological
side effects provoked by pure THC (Zuardi et al. 1982). CBD modulates the
pharmacokinetics of THC by three mechanisms: (1) it has a slight affinity for
cannabinoid receptors (Ki at CB1 = 4350 nM, compared to THC = 41 nM,
Showalter et al. 1996), and it signals receptors as an antagonist or reverse agonist
(Petitet et al. 1998), (2) CBD may modulate signal transduction by perturbing
the fluidity of neuronal membranes, or by remodeling G-proteins that
carry intracellular signals downstream from cannabinoid receptors, and (3)CBD
is a potent inhibitor of cytochrome P450 3A11 metabolism, thus it blocks the
hydroxylation of THC to its 11-hydroxy metabolite (Bornheim et al. 1995).
The 11-hydroxy metabolite is four times more psychoactive than unmetabolized
THC (Browne and Weissman 1981), and four times more immunosuppressive
(Klein et al. 1987).
CBD provides antipsychotic benefits (Zuardi et al. 1995). It increases dopamine
activity, serves as a serotonin uptake inhibitor, and enhances norepinephrine
activity (Banerjee et al. 1975; Poddar and Dewey 1980). CBD protects
neurons from glutamate toxicity and serves as an antioxidant, more potently
than ascorbate and α-tocopherol (Hampson et al. 1998). Auspiciously, CBD
does not decrease acetylcholine (ACh) activity in the brain (Domino 1976;
Cheney et al. 1981). THC, in contrast, reduces hippocampal ACh release in
rats (Carta et al. 1998), and this correlates with loss of short-term memory consolidation.
In the hippocampus THC also inhibits N-methyl-D-aspartate (NMDA)
receptor activity (Misner and Sullivan 1999; Shen and Thayer 1999), and
NMDA synaptic transmission is crucial for memory consolidation (Shimizu et
al. 2000). CBD, unlike THC, does not dampen the firing of hippocampal cells
(Heyser et al. 1993) and does not disrupt learning (Brodkin and Moerschbaecher
1997).
Consroe (1998) presented an excellent review of CBD in neurological disorders.
In some studies, it ameliorates symptoms of Huntington’s disease, such
as dystonia and dyskinesia. CBD mitigates other dystonic conditions, such as
torticollis, in rat studies and uncontrolled human studies. CBD functions as an
anticonvulsant in rats, on a par with phenytoin (Dilantin, a standard antiepileptic
drug).
CBD demonstrated a synergistic benefit in the reduction of intestinal motility
in mice produced by THC (Anderson, Jackson, and Chesher 1974). This
may be an important component of observed benefits of cannabis in inflammatory
bowel diseases.

--"Cannabis and Cannabis Extracts:
Greater Than the Sum of Their Parts?
John M. McPartland
Ethan B. Russo"

big pharma hit for billions in fraud -ya dont say

War on Weed

Auger8 says...

I could be wrong on that I'm looking into it but "Cannabis is ranked one of the least harmful drugs by a study published in the UK medical journal, The Lancet" As shown in the following graph. You'll notice tobacco is significantly higher on the scale. Graph Here

[edit] ok there are about 100 chemical compounds in cannabis however most of them are responsible for the fragrance/aroma of the plant they're also naturally occurring and not additives. When I was talking about the chemicals in cigarettes I was mainly referring to additive chemicals and known poisons that are added in for supposed flavor, like ammonia and cyanide.

>> ^BoneRemake:

>> ^Auger8:
Cigarettes have something like 300 chemicals in them that's where the cancer causing agents come from not the tar, marijuana has like 3 THC, Chlorophyll(planet matter), and actually that's all I can think of so I guess it's just 2. Anyway I'd choose marijuana any day over something that has cyanide in it to give it flavor wouldn't you?

complete bullshit. Cannabis has hundreds of cannabinoids/chemicals in it.

War on Weed

BoneRemake says...

>> ^Auger8:

Cigarettes have something like 300 chemicals in them that's where the cancer causing agents come from not the tar, marijuana has like 3 THC, Chlorophyll(planet matter), and actually that's all I can think of so I guess it's just 2. Anyway I'd choose marijuana any day over something that has cyanide in it to give it flavor wouldn't you?


complete bullshit. Cannabis has hundreds of cannabinoids/chemicals in it.

Judge Makes The Case For Medical Marijuana -- TYT

vaire2ube says...

It's all a fraud, but a voluntary one. The CSA is unscientific and doesn't abide by its own classifications... but has been adopted by the States, who now don't question it.

Since 2003, the US Govt, through the DHHS, owns a patent on Cannabidiol - a main ingredient in the cannabis plant and component of the smoke from combustion of the plant -- thus invalidating the claim against medicinal value. Patent Number 6630507. So why is it illegal? Guess who is in charge of authorizing the studies?

You will have to look it up, because for all intents and purposes it is actually the DEA who sets AND enforces drug policy in our country. (of course, they swear they are just followin the orders which come right from our citizens! they are doin the good work by keepin us from getting free medicine. don't you remember asking them to ruin your life just for fun?)

The current DEA director LYINGHEART actively blocks all attempts at scientific discourse regarding marijuana, yet screams the sky is falling because of synthetic cannabinoids that have been available for over a decade, proving that the DEA is up its own ass, at least partially enough to block hearing and sight. They can still smell pot smoke though.


Marijuana is not a drug. The plant isnt a drug. The chemicals inside it are... and they have medicinal value. So why make the plant illegal? Because its free. Number one, period.

prescription pain killer abuse is at an all time high and rising with the population... so one has to question the motivations of people who keep a free effective drug illegal. The most therapeutically safe substance known to man is classified with Heroin in terms of impact on health and society. That alone should be a warning flag to any thinking citizen.

Sickening, yet the only logical conclusion in light of all the facts.

HR 347 - Trespass Bill Threatens First Amendment -- TYT

vaire2ube says...

That's a cool law. Laws are fun. Lets all make laws!!

By Executive Order in New Jersey:

The Order, announced today bans ten entire classes of synthetic compounds that imitate the effects of marijuana, and all known or unknown variants of the drug that would fall within each class. The Order also expressly includes “any other synthetic chemical compound that is a cannabinoid receptor agonist and mimics the pharmacological effect of naturally occurring cannabinoids” – in other words, any synthetic chemical that mimics the effects on the brain of marijuana’s active ingredient

—–

Citizens SHALL NOT stimulate their Cannibinoid Receptors with ANY SUBSTANCE
They SHALL NOT protest this either.

Spice was Invented by The War On Drugs

vaire2ube says...

Here's the scoop:

JWH-018 makes you feel more stoned than the first time you got stoned. If you don't know what that means, well... no wonder people were freaking out.

JWH-122 which i use now daily, is a LOT more mellow. I can smoke it once and be stoned all day but relaxed, more CBD like. 75$ for 5 grams that lasts months. I'm talking pure powder that i mix into my own smokable. I don't smoke blends of rose hips and bay bean sprayed with acetone dissolved JWH, like vendors sell.

These are synthetic cannabinoids, they are full agonists and bind very tightly to the CB receptors. THC and CBD are partial agonists and mitigate each others effects. These chemicals are no joke and have been available for a long time, proving that if cannabis was legal that NOTHING bad would happen. These drugs are far more potent and the world has had access to them for years by mail-order, and the results are in.

You WILL freak out if you are not a cannabis user or someone with experience smoking. I've smoked for over a decade before trying these compounds and it was like i was 16 all over again. The strange thing is the intense effects last only up to an hour, then you're ok again. The effects seem additive, whereas you can smoke cannabis non-stop, you actually reach a point of intoxication that can be nauseating (happened two times on JWH-018, I was sweating, throwing up, couldn't come down... but then I did... and it happened from using too much 018 too quick).

Also, my anxiety and depression seemed very well managed on a combination of JWH-122 and Sertraline HCl (gen Zoloft). I no longer get angry and sad, and want to just throw it all away because the world is big and scary.


Cannabis prohibition is very strange. I like being told as an American that i can't be tortured, held without cause, executed in street... but the can'ts should all be bad things. I can't smoke cannabis BECAUSE I'm American. Even the Israeli govt is legalizing medical marijuana for its citizens, yet my country who gives them money to exist, says I cannot. I can't because I'm American. Wierd. So I'll pay less to get more stoned.



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