>> ^E_Nygma:

It too is a cox-1 and cox-2 inhibitor,
>> ^lucky760:
Fascinating and something I've always wanted to know.
Now how do acetaminophen and naproxen sodium work?



I've found that gay men and horny women stay away from the cox inhibitors.

See bamdrew's explanation on paracetamol; it's just the trade name of acetaminophen in certain parts of the world, as tylenol is the tradename in the US. naproxen is another NSAID (non-steroidal anti-inflammatory drug) like ibruprofen, and so has a very similar mechanism of action to it. It too is a cox-1 and cox-2 inhibitor, and other drugs exist which are more selective to one or the other, but most have been associated with severe although rare side effects (vioxx was a cox-2 selective inhibitor)

>> ^lucky760:

Fascinating and something I've always wanted to know.
Now how do acetaminophen and naproxen sodium work?

It is generally understood that acetaminophen/paracetemol binds and reduces oxidized, 'highly active' COX-2 enzymes... this chills out the COX-2 activity until it is oxidized again and cranks back up. So imagine in this animation acetaminophen kind-of causing that active COX binding site to close up a little for a while, and preventing it from working in that way.

Acetaminophen also doesn't appear to have a lot of anti-inflammatory action near the actual site of inflammation, but rather more globally throughout the body; folks hypothesize a lot about the reason for this, but I like the simple answer that acetaminophen itself can't reduce oxidized COX enzymes in an injured area surrounded by high levels of oxidative species.

(nerd fist-bump)

>> ^MilkmanDan:

>> ^spoco2:
But what about paracetamol? That's different, because you can take the allowed dosage of that and the allowed dosage of ibuprofen at the same time without interaction... but how does it work?

Paracetemol is the major painkiller here in Thailand, which annoys me because I believe that I am essentially immune to it. I took paracetemol (tylenol) often when I was in my pre and early teens for migraines. At some point, I found that it just wouldn't do anything for me anymore. Ibuprofen and Aspirin both work great, so I always use those when I have a choice -- but the default is always Paracetemol here.

>> ^wormwood:

"Michigan's Attorney General, Mike Cox" ... and his fellow petition signers Mike Hunt, Dick Hurtz and Hugh G. Rection...


You forgot Harry Johnson.

The thumbnail image for this video has been updated - thumbnail added by Boise_Lib.

Musically, pretty damn shite really.

It's amazing how huge Prof. Cox (tee hee) is in England. I listen to a bunch of English podcasts, and he's super famous over there, stupidly so.

Hurray for science

>> ^renatojj:

Wow, if he stayed in character all the time, I bet he'd be chewing on Jodie Foster's ribs before the end of the movie. That's how amazing this actor is.


Yeah, fair enough but I still prefer Brian Cox's take on "Hannibal Lecktor" in Manhunter. Hopkins likens his performance to a children's monster tale and he's right- his lecter has the characteristics of a classic movie monster. Cox on the other hand was chillingly real.

I've always wondered why Brian Cox didn's reprise the role in Silence of the Lambs, he refuses to comment on it.

edit: Okay, he has spoken about it, if anyone's interested this is a very good interview http://www.denofgeek.com/movies/1075052/brian_cox_interview_manhunter_hannibal_the_cannibal_adaptation_michael_mann_and_brett_ratner.html

So heres the current list with my own interpretation of the subjects of each.

COFFEE MAKES ME POO = bowel movements
Eddie Izzard - Do you want a cup of coffee? = mating rituals
The Most Expensive Coffee in the World = civet droppings
South Park on Coffee = caffeine's affect on kids
Charlie Brooker vs. Nescafe - (VideoSift Coffee Mug Compo) = commercial/advertising
The latte zoo- (mixed animal latte pours) = drinkable art
Kramer CaffeLatte -- Seinfeld = caffeine's affect on racist comedians
The Office - Coffee and Cocaine = caffeine's affect on business quotas
The Simpsons - Beer Coffee = stereotypes of Aussies
Wish I had this coffee maker! = middle American consumerism
Coffee Snobs - snobby hipsters
This is Coffee (1961) = **coffee**
How to make Iced Coffee = what ice is used for
Six million dollar man coffee commercial = commercial/advertising
The Clover Coffee Machine - Hand Built By Stanford Engineers = Engineering
Denis Leary - Coffee = douchebag
How Sherlock Likes His Coffee (Sherlock BBC) = a fictitious characters taste/preferences
Dr. Cox and the Coffee (Scrubs) = flirting
How to make cold brew coffee the homemade way! = how to throw off the shackles of consumerism
Chad Vader Coffee = Star Wars copy right infringement
Austin Powers' coffee mix-up = the old Switcheroo comedy bit
History of Coffee = average joes bid for youtube attention
Join the Coffee Achievers! (Weird1984 coffee ad with Bowie) = commercial/advertising
Mad TV Coffee Maniac = caffeine's affect on Keanu Reeves
Coffee Panda = drinkable art
Charlie Chaplin Drinking Coffee = bowel movements
La recette des cupcakes jamais vus... au tiramisu = Tiramisu
Vodka & Coffee = alcoholics
Latte Art - Swan Lake = drinkable art
How To Cold Brew (COFFEE) = commercial/advertising
How to Pronounce Cappuccino = Linguistics
Strange To Meet You = caffeine's affect on European Directors/Actors
Columbian Coffee Crystals = commercial/advertising parody
Juan Valdez ~ Colombian Coffee 1982 = commercial/advertising
Coffee and the Brain = health benefits of caffeine
Milk With Your Coffee? = how boobies lactate
"The Coffee Wars" - (Mockumentary) = dangers of caffeine addiction
60 Cups, 1 Bald Head = how German scientists are full of shit!
It puts the coffee on its skin... = dangers of caffeine addiction
The Journey of the Coffee Bean = **coffee**

http://videosift.com/video/Dr-Cox-and-the-Coffee-Scrubs

>> ^shole:

Things do need to be simplified when doing a show of a limited time.
They can't do a show where it's like browsing wikipedia, jumping from one subject into some minute detail of it, and digging deeper until you forget what you were studying in the first place.
Not that i would mind if someone were to make a show like that.


exactly but the compromise is not saying verbs and words that have no real meaning. The compromise is saying , " this is what it is called " " these scientists have done x " "the ramifications are y"
and then include links at the end of a show or a short sting that tells people where to go if they are interested in perusing it or what books to read / maths to study.

The general public is ignorant as to what the basic principles of the scientific method are so trying to then explain the more abstract aspects of quantum mechanics is utterly futile.

Still the lecture was a realy good effort and most of it was fantastic , IT is depressing to me that your average joe on the street probably doesn't know of the slit experiment and that a good proportion of the adults in that room with him didn't .

Look up Richard Hammond's Engineering Connections. When it works it's quite entertaining, when it doesn't quite work it's exactly as you described (and still a bit entertaining).
In reply to this comment by shole:
Things do need to be simplified when doing a show of a limited time.
They can't do a show where it's like browsing wikipedia, jumping from one subject into some minute detail of it, and digging deeper until you forget what you were studying in the first place.
Not that i would mind if someone were to make a show like that. :

This goes back to exactly what I said when the lecture was put on-line , and that is that some things can not be simplified and understood to any usfull level. Sure have some vaague descriptions and get people intrestead but then make sure you tell them that it simply cannot be understood unless you do some research into it and understand the principals behind it to a reasonable depth.



http://videosift.com/video/Professor-Brian-Cox-A-Night-with-the-Stars

"I actually think its probably futile trying to explain or teach Quantum physics to the general public other than saying it exists and this is how things are. It would be far more productive teaching the importance of science and the scientific method and the philosophy of science as that is something that can be grasped fully by sum-one of very limited knowlage of the subject matter and has the largest ramifications. "

>> ^Fletch:

Everything NDT says sounds like the most astounding fact he's ever heard, and that you should be astounded by it too. His meter - every enunciation, accentuation, and pause - sounds affected and I, for some reason, can't stand to listen to him. I've tried. He talks about things I'm interested in and I enjoy reading what he has written (I have "Pluto Files" and "Space Chronicles" on my Kindle), but when he starts talking, it just sounds like he's talking to five year-olds to me.
F ck it, upvote.


I know exactly what you're saying. There's a british version of this and he's called Brian Cox. Every single time he speaks, i feel my skin crawling that he knows that he has to try and manipulate the audience into feeling emotion that they just don't feel.

I subscribe to the principle as well. I agree, the connectedness of the universe is absolutely amazing. When you think about the familiar vs. the unfamiliar, the known vs. the unknown.... we know each other, we know the planet we live on and we feel safe here, but there's an infinite chasm in all directions around us. Sometimes when i consider this i can give myself vertigo.

If i were trapped in a cave with the most fundamental islamist ever, and we didn't know what lay on the other side of the collapsed wall, we'd eventually cooperate and work together to get out, to see what's there. Maybe we find something great out there, or maybe we have to build some defences to make ourselves safer in the cave.

Put us on earth, and we put bombs in each other's homes. The knowledge of how amazing the universe is really does lift you up, places you above all the stupid racism and general jingoism. But you can't fake it or inspire it, you either feel it or you don't.

Having said that, at least they're getting the field of physics more attention, and maybe they might influence some kids whilst they're influence-able.