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CRISPR-Cas9 ("Mr. Sandman" Parody) | A Capella Science

eric3579 says...

CRISPR-Cas9
Bring me a gene
Encoding for a specific protein
Make a few snips at this coded locus
You work so well inside a streptococcus
Cas9
I'm so alone
Without your scissors in my chromosome
Cut me up and do it clean
CRISPR-Cas9 bring me a gene

CRISPR-Cas9
Keep me a gene
A viral sequence you've already seen
Chopped into bits and stored as genomic
With clustered repeats
That are palindromic
Cas9
Bind with this code
Use it to target infections of old
Immunized like a vaccine
CRISPR-Cas9 keep me a gene

CRISPR-Cas9
Cut me a gene
With a precision that I've never seen
Unzip a strand and interrogate it
Seek out your sequence until you locate it
Cas9
Lock into place
And do your job as endonuclease
Chop just like a guillotine
CRISPR-Cas9 cut me a gene

Snip snap!
CRISPR-Cas9
CRISPR-Cas9

CRISPR-Cas9
Bring me a gene
By commandeering my repair routine
A strand to match your severed location
For some homologous recombination
Cas9
Cheap and precise
Rewriting genomes from microbes to mice
And soon the humble human being
CRISPR-Cas9 bring me a gene

CRISPR-Cas9
Give us a gene
Give us a miracle like that one Nazarene
‘Cause giving the lame their legs and the blind their sight is
In view for dystrophy and retinitis
But CRISPR-Cas9
What if you fall
Outside our power and inside us all
That really could incite a scene

When this terrible wonderful power unsettling
Opens the door to unethically meddle
Is ev’ry congenital malady bettered
Sufficient to warrant genetics unfettered
To modify man in the manner of Gattaca
Raise up a mammoth or make a rattata
Dramatical medical means to eradicate aging
Or cancer or make a fanatic
A mass epidemic a weapon nefarious
Single mosquito to wipe out malaria
Send in a viral infection to ferry a
Cure to the cells of an HIV carrier
Freed of disease as we're free to uncover
What nature and accident failed to discover
And free to be other than
All that we ever have been

CRISPR-Cas9
CRISPR-Cas9

Oh CRISPR-Cas9
Bring us a gene
You wondrous ribonucleoprotein
You have the power to vanquish or save us
Who would have thought that the microbe that gave us
Cas9
S. pyogenes
The source of strep and flesh-eating disease
Housed this marvellous machine
Full of uses great and obscene
CRISPR-Cas9 bring us
Please don't sting us
Cas9 bring us a gene

With adenine
And thiamine
Incite a scene
Cas9 bring us a gene!

MrFisk (Member Profile)

How 'Stranger Things' Nailed The Perfect '80s Title Sequence

eric3579 says...

Here is the title sequence https://youtu.be/VPDZkbq0Zp8

So curious to know if they delivered it complete as the above.
How much work goes into it? How big a team? How Many hours? What does the work entail? Also what does this cost?

Now im annoyed as i have tons of questions i assume will never get answered.

First Few Minutes of Beautiful Indie Game INSIDE

Babymech says...

I didn't think it was out of nowhere. I was also really happy that the end sequence went on for as long as it did.

johncusick2 said:

its extremely short, i finished it in 3 hours, the ending is very WTF out of nowhere. good atmosphere but expensive for the few hours gameplay

STAR TREK BEYOND Official Trailer #2 (2016)

ChaosEngine says...

Yeah, sign me up for the "this looks awful" train.

Right now, there is one thing that might make me want to see this and that's the fact that Simon Pegg wrote it.

Because Simon Pegg is awesome and he actually cares about this.

But I can picture the scene now...

INT: PARAMOUNT EXEC's office
SIMON PEGG: "I've just finished the screenplay for the new Star Trek movie"
PARAMOUNT EXEC flicks through script, obviously not reading it

PARAMOUNT EXEC: "Great.. great! great work, Si (can I call you Si?) Now can we add some ninjas and dirt bikes?"

SIMON PEGG: "er, that's not really what it's about. And please don't call me Si."

PARAMOUNT EXEC: "Thanks Si! So we'll have those ninjas and dirt bikes in the next draft. Also good news, you'll never guess who we got to direct it."

SIMON PEGG: "I was thinking maybe Duncan Jones. He did some great sci-fi with Moon."

PARAMOUNT EXEC: "nah, he's off making an extended blizzard cgi sequence! No, even better, we got Justin Lin!"

SIMON PEGG: "The guy from Fast & Furious? Why? why would you...."

SIMON PEGG breaks down crying

PARAMOUNT EXEC laughs maniacally

CUT TO : Ext GENE RODDENBERRY's grave

GENE RODDENBERRYs corpse spins out of grave

"BERNIE & HILLARY" — A Bad Lip Reading

Ferrari F40 + Snow Chains + Snowy Mountain = Win!

blutruth says...

The care is owned and driven by Takeshi Kimura, a wealthy property developer who also owns a Ferrari F50, Enzo, 458 Speciale, McLaren P1, Porsche 911 GT3RS, and a Lamborghini Huracan Super Trofeo (at least according to the internet), so I'm fairly confident it's not a kit car. The F40 suspension is height-adjustable, so they probably set it as high as possible for the snow sequences.

Payback said:

As Chaosengine said, yes, the F40 does have a wing.

Part of my belief comes from the lights, but mostly it's the ride height. There's enough room under this car for a real F40 to drive under it...

Something yells "FIERO!!" and not "FERRARI!!"

Halt and Catch Fire opening credits

Deepwater Horizon (2016) – Official Movie Teaser Trailer

Mordhaus says...

On January 30, 2015, it was reported that Lone Survivor director Peter Berg had replaced Chandor to re-team with Wahlberg for the film. Chandor exited due to some creative differences.

Read, 'not enough sturm und drang action sequences for a disaster movie', get a new director.

Videosifts Sarzys Best And Worst Movies Of 2015

bareboards2 says...

Agree to disagree, I guess.

I was bored by the long beginning sequence and I certainly rolled my eyes more than once at plot points. Part of the beauty of the original was its grounding in Saturday serials that played before the movies that would leave you in a "cliffhanger" moment, then skip ahead to the following Saturday without explaining things. I don't think the reboot was grounded enough in that delicious silliness.

In my opinion, of course. I'm just one person. Clearly millions disagree with me. There isn't any right or wrong here. Although my unedited response upon walking out when it was over was snarky and judgmental. I'll apologize for that, but not for my personal experience of the movie that culminated in that one line judgemental-of-other's-fun review.

JustSaying said:

You don't have to be blind to love SW:TFA, you just have to appreciate a very well made blockbuster for the whole family that doesn't insult an adults intelligence.

Star Trek: Renegades (Episode 1)

jmd says...

Wow.. so.. a lot of good.. a lot of bad. Actor performances and writing were all over the board. The seasoned actors were all awesome, and sean young who at first seamed out of place turned out a wonderful performance as Dr Lucien and a hopeful character. The space sequences were numerous and well done with great ship models. Pyrotechnics were kept minimal as those are still hard to do in style in CG so its best to keep it good or keep it out.

The bad how ever. The klaxon mining facility was just all kinds of horribleness. The bad layering, the over the top and ridiculous amounts of shooting flames, and the cherry on the top is the introduction to the main bad guy race with their mask straight out of planet of the apes. I seriously can't believe someone though those were a go for filming. Also most of the planet intro scenes are more of a neo electro artistic style rather than something that looks real. This is a bit surprising since I would think the "animated paintings" from enterprise and voyager era would have been pretty low cost. The worst of the performances is by Crystal Conway, chekovs great great grand daughter.

Writing was also up and down. I think the story was ok with 2 general sins being committed. #1 a little to much backstory stuffed into the first 30 minutes. Icheb's borg roots were uncomfortably recited in a full scene in front of his own crew who would have already known this, and should have instead been a few lines to say he was a borg and then leaving his origin story for a later date. And #2, a lot of plot points like the doorway placed on earth ahead of time and being able to transport through the time distortion seem awfully convenient and tries to absolve the episode from going any farther in complexity. This is a pretty big sin when you consider these need to be %90 self contained episodes. Also it seems no matter how bad you are or how much of an outlaw you are, finding you in the star trek universe is one scene away. I do have to give props to Corin Nemec as the captain of the other ship. His crew is actually pretty bad but I liked him. I was sad to see his script called for more shooting and less investigating. Also I feel bad for the horrible looking bridge set they built him.

Still in the end, I am a big supporter for more star trek. I loved voyager and I think the renegade crew is actually in good shape. Lexxa, is not BAD but needs more work. Like another comment I read, she doesn't seem very smart about anything, no hidden talents. Her fighting is pretty horrible and scripted, and while she pulls the bad girl image off, she lacks the muscle or fancy footwork to look like she could actually hold her own physically.

Ronara was largely forgettable and suffered from the same origin scene stuffing scene sin as Icheb. Chekovs 2 girls on the other hand look like good additions and I think they pulled the female andorian well. Nothing dramatic in their acting but at this point, not sucking is a good thing.

Unfortunately who knows how many years till we see eps 2. I seem to recall this one finished its kickstarter long ago but delayed heavily.

Swing Hip Hop. Or Crump Swing. Dance Battle!

gorillaman says...

My ultimate social terror is that one of these fucking things will somehow spontaneously generate itself around me, obliging me to improvise some sort of limb-flailing bullshit in response.

I don't know what sequence of events could lead to that actually happening, but the sight of two lines of people dancing at each other brings me out in the fucking sweats nevertheless.

Robot Chicken DC Comic Special

Smarter Every Day - You won't believe your eyes

dannym3141 says...

I've always said the word genius is bandied around way too much, and this video is a fine example. CRT screens/tvs follow the same idea - individual lights illuminate in sequence quickly enough to form a static picture, each pixel changes very slightly 100 times per second (refresh rate) to give the illusion of the original picture in motion. The CRT beam scans ("rasters") from top left to bottom right (for example) in exactly the same way that the device in the video spins (it rasters in a circle) and however many times it spins per second is the refresh rate.

It's a cool project and his PCB work is nice, and he's done a good job of translating a picture into a timed set of lights. The videographer uses the term genius because he was not previously aware of the long history of rasters. This would be a useful tool for teaching children about the process - CRTs might not be popular anymore, but CCDs are fundamental to (astro)physics, and the principles behind both cover a huge range of potential teaching topics.

HARDCORE Official TIFF trailer (NSFW)

Bruti79 says...

I saw it yesterday at Tiff, it was amazing. The story was fun, but not too serious. The action sequences had some insane stunts. I imagine that the insurance policies in Russia were a lot more lapse. I recommend going to see it, it's just a fun movie. =)



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