Um….what?
Full of fact. I wonder what far right propagandists are saying.

It had time (2:30 am), place(Pelosi’s SF home), injuries (arm, hands, and skull fractured), weapon (hammer), identity(42 year old David Dipappi), and exactly what he did(broke in yelling where’s Nancy wielding a hammer, tried to tie up the husband and wait for her, husband called 911 and dropped phone, police came and stopped the murder in progress).
It’s nothing but facts. I think you didn’t watch it. It was short, but still too much fact for your little brain to accept. Such a baby. Do you think shoving your head farther up your ass makes you look strong? Smart? On the ball? It only makes you look scared and intentionally ignorant, buddy. Ask anyone not up there with you.


What isn’t there besides his long history of spouting the exact crazed far right lies you spout daily? Election fraud, COVID’s a fraud, Trump won, Jan 6 was by ANTIFA, Trumpists believe in law and order, Russia is our friend and ally, Lil Kim is a genius and benevolent leader, Democrats are in a pedophile vampire cabal where they take children to pizza parlors to eat their pineal glands and gain immortality….🤦‍♂️

I won’t post because this video can’t be posted off YouTube, you fuckwit. I didn’t bother looking for more, it had plenty to trigger you so served it’s purpose. This story is everywhere, even on Fox, people without cranial rectosis don’t need it spoon fed to them….but you do.

I guess you just need more MAGA terrorism, more violent attempted murder of the elderly, more hard core anti democracy, and more deadly anti American MAGots actions to be posted, although for the life of me I can’t fathom why….but ok, I’ll find something and post it just for you. Don’t say I never gave you anything.

https://videosift.com/video/Failed-MAGA-Assassination-Pelosi-Husband-Attacked-In-Home

Infinitely more fact and information than you EVER produce, buddy. You have been hiding from your enemy, reality, for at least 6 years now. It effects your family in ways that are severely detrimental to their mental and physical health. You have admitted this in the past, but can no longer admit reality so I’m certain you won’t admit it now. Please don’t murder your family like so many MAGots have…it wouldn’t be a bit surprising if you did.

I never said she was, only that it’s likely, and that breaking into a campaign headquarters is, by definition, a political crime. It’s still quite possible she or her campaign put him up to it, intentionally hiring a homeless looking guy so people like you would say exactly what you said (once fed it), or not. Nothing has indicated otherwise. Even homeless guys know campaigns don’t keep cash or jewelry around, nothing to steal there but campaign data, not the stuff homeless people steal.
Either way, it’s a political attack to break into a political headquarters, even if that’s not the intent.

How about wait and see before declaring her innocence based on nothing. Can’t wait for a fact before you post no story pushing a fake innocence. Even if she’s not involved directly in this crime, her rhetoric is responsible for hundreds of credible death threats and other threats and attacks. She may not be guilty of this crime, but she is far from innocent.

Oh, I’m so sorry, only bob is allowed to “push narratives” or make suppositions without having all the facts, or in his case any facts. You have no leg to stand on after years of pushing obviously fake stories that, surprise surprise, all turned out to be totally fake with no evidence on which to base them in the first place. Don’t whine now that someone else jumps to conclusions like you always do.

Know what’s definitely not fake? The violent attack against Pelosi’s elderly husband in an attempt to murder her….I suppose you would say it’s wrong to call that a politically motivated attack too.

You are gullibility incarnate. You still believe covid is a hoax, and just a cold, and a plot by China to destroy the west by infecting itself. You still believe Russia didn’t ever interfere in our elections, and Trump really won the popular vote once. You believe Jan 6 was ANTIFA and BLM not MAGA despite the guilty pleas, and that stealing nuclear secrets and keeping them in public hallways where Chinese spies repeatedly brought recording equipment and roamed freely is a “nothing burger” but Clinton not seeing the murky future is a high crime. Everything you claim to believe is certifiable nonsense, bob. Pretty certain you think long dead Hugo Chaves used Italian space lasers to change votes in dominion voting machines in a shared plot with the Illuminati and the sleestacks (lizard people) to hurt Trump because he was going to expose their pedophile vampire club where they vivisect children for pineal glands. ROTFLMAHS!!

DMT is released from the pineal gland and you go on the most epic journey through the Multiverse

See now I can tell you really know nothing about it, since you do not need to be a chemist. You could grab yopo seeds and just smoke those (they were found in a 3,000 year old bowl in Costa Rica - people have known about it for a long time, then for some reason it became a secret - I think Christianity stepped in to get rid of the knowledge of it), it's found throughout nature - you could grab some acacia bark, boil it and drink. It is safe and it is not dangerous. It's been studied many times and is still being studied for how it affects the brain & as well for it's natural therapeutic effects. It is believed to be endogenous - that is it already exists within your being (it's in many plants and animals, recently found produced in an animal's pineal gland). Not a huge Tool fan but they often allude to this substance, the pineal gland, Alex Grey's artwork - pretty sure they know full well of what it is.

Anyway, I totally did derail the comments and I do apologize for that, but you guys were calling me "religious" and downvoting me so I took offense. I derailed mostly to post the link about Dawkins having a profound experience that humbles his approach, it was a joke - but really I think all of us that have experienced the wonders would love people like Dawkins to spend the 5-10 minutes to experience it and then hear what he has to say about it.

*promote

I agree with ya.

There are a lot of jumping to conclusions and pseudo-scientific & "spiritual" & "mystical" hyper-babble in there.

It's really not about being "right" about anything; I think when people go on their spiels about it - there is a lot of personal fervor and frustration that this is obviously something extremely important to study because it "seems" like the "impossible". That it is so impossible to describe that it seems like anything or everything. Even when I think about times I have been under it and try to imagine what it was like I feel like I am going to bust reality wide open.

I do believe that it is bizarre that this chemical exists and seems to interact with us in an extremely intense and vivid way. It will be interesting to find out what scientists find out about this thing in the next 50 years and hopefully they can figure out more than "It is attaching to 5-HT_ & 5-HT_ receptors".

In 2013 scientists found that a rat's pineal gland contains this molecule so the future is going to be pretty interesting on this topic.

For a while it was thought that Strassman's claim that DMT production in the brain comes from the pineal gland was false. Even Strassman tried to redact this as it was not scientifically proven.

3 or 4 months ago scientists discovered that rats pineal gland's DO produce DMT.

DMT containing plants are all around the globe and have been throughout time. Do you really think it was just tribesmen in the Amazon using it all of this time? I think not.

Like McKenna said, "DMT is not a secret it is THE secret."

I think it is very important that people know, partake and let the boundary dissolve. It is so important that I want to tell my parents, "before you die, you NEEEEEEED to do this!!" But, I can't because of the benign restrictions of this society. Life is about experiences, and this is an experience quite extraordinary, why not take 5-10 minutes and see what is there?

I think it is more likely not a string, but a small whip antenna connected to the pups pineal gland in his brain.

"What i hope for is to see less videos about religion and atheism and for people to loose interests in this retarded war. I got tired of all the video spam on these subjects long ago, but they seem to keep returning."

As long as there be unfulfilled, frustrated, bitter, and uncreative folk, there will be arguments "for" or "against" anything and everything.

Religions make Semolians....greenbacks...MONEY. Including the 21st Century religion of Atheism. Both sides will always profit in our current paradigm, where money reigns supreme. YES! Has not the choggie been spouting from day 1 here on the sift (with a chambered downvote shotgun at the ready) that the rabid, sophomoric, finger-pointing and name-calling by both sides is a circle jerk of mammoth proportions?

The sift has enough video wreckage-those who play here and show up to look, usually have a brain with a solid handle on a take on God. Personally???...If ya wholesale rule out a creative force in the uni/multiverse that may or may not be a benevolent omni-being or catalytic observer/initiator, well, you simply ain't had a third-eye opening experience, and ya need to have yer pineal gland fibrillated!

Praise Bejesus Mary Magdaloin!

I swear to fucking christ, the first person at work who does that "fish rap" gets a goddamn axe in their pineal gland.

I know, lie down onna table, atta party, and have all your friends place their cellphones in a sunburst array around your head.....have them all dial out at once, you doubters should feel a tingle, which should be enough to convince you that your friends attention is at least part of the sensation you feel between your eyes-perhaps yer pineal gland will activate long enough for your third eye to wink at itself.......

^yikes, that cat box looks terrifying (no joke, I'm deathly allergic). sounds good to me rottenseed. I would imagine citing studies and research that the EPA & NRC evaluated would hold up to that standard. I think the NRC's findings speak volumes but something we can all hopfully agree on (except maybe rembar?) is that while they found tons of research and evidence that warrants serious concern, there was no overwhelming evidence in any one area of fluoride exposure and they advocate further research and evaluation of fluorides effects on the brain, endocrine system, thyroid, pineal gland, diabetes, immune system, liver, kidney and a host of others.

A copy of the brief is available here for free. Let me state in advance that this study only looked at research on fluoride found naturally in the water and not Hydrofluorosilicic Acid or Sodium Fluorosilicate (the kind from the phosphate fertilizer industry) that is used when artifically fluoridating water.

Drug induced sleep can be of two varieties, (1) "drug assisted" (mostly benzodiazepines, like lorazepam (Ativan), or imidazopyridines, like Zolpidem (Ambien), and (2) true "general anesthesia." Benzos assist sleep but because they are potent amnestics, one is less likely to remember a dream, even if you had one. Melatonin is not a benzo. It is an endogenous hormone, produced by the pineal gland. Melatonin is involved in regulating circadian rhythms, although it is not the main determinate. High doses of melatonin seem to be associated with more REM sleep and more dreaming.

"General Anesthesia" is not normal sleep and, rather, is unconsciousness produced by specific inhibition of neuronal communication (synapsis), whether by inactivation of protein channels on cell membranes, or by inhibition of GABA receptors, (a neurotransmitter). Deep levels of general anesthesia can flat-line your EEG, meaning your brain is totally shut down and is doing no synaptic work at all.
However, people may do normal sleeping after recovery from general anesthesia and they do occasionally relate dreaming during the period of recovery. In particular, the sedative/anesthetic Propofol is associated with some "erotic" dreaming and I have had some people relate rather vivid and interesting content. I had one older gentlemen who wanted to be put "back to sleep" so he could continue his "relations" with Gina Lollibrigida.

SCIENTISTS CHALLENGE NATIONAL ACADEMY OF SCIENCES STANCE ON FLUORIDE

Professors of Chemistry Albert Burgstahler (University of Kansas) and Paul Connett (St. Lawrence University) and Professor Emeritus Lennard Krook (Cornell University) will be joined by Dr. William Hirzy (representing the union of scientists and attorneys at EPA headquarters) and New York attorney Paul Beeber in presenting information showing fluoride is neither an essential nutrient nor a beneficial element, contrary to what the NAS is attempting to establish, and that Americans are now over-dosed with that chemical.

Professor Burgstahler, who has been an active researcher on the toxic effects and chemistry of fluoride for over thirty years, will cover in detail the unscientific nature of the NAS's justification for attempting to anoint fluoride as an "beneficial element". He will explain errors in the NAS's arithmetic and reasoning on the subject and point out the bias of the NAS panel members involved. Professor Connett will present information on the mechanisms of fluoride's toxic effects, including suppression of the activity of the pineal gland, which responsible for many critical aspects of life such as aging and adaptation to day/night cycles. He will also discuss how fluoride's chemical properties explain much of that substance's toxicity, and the present state of America's over-dosing by fluoride and the role of the American Dental Association in it.

January,1999
CONTACT: DR. J. WILLIAM HIRZY, NTEU CHAPTER 280
PHONE: 202-260-4683 FAX: 202-401-3139 EMAIL: HIRZY.JOHN@EPA.GOV

rembar has pulled two studies from THE NATIONAL CENTER FOR BIOTECHNOLOGY PUBLICATION

Community water fluoridation and caries prevention: a critical review.
Position of the American Dietetic Association: the impact of fluoride on health.

one would think if his real intent is to determine the validity of adverse health affects on fluoride that he would at least acknowledge that there is abundant scientific literature on the subject (whether he agrees with it or not).
He has repeatedly suggested that anti-fluoridation arguements are conspiritorial and lack scientific evidence. Once again I will show that there have been scientific studies done in which the outcome shows concern for adverse health affects of fluoride. (these studies are pulled from the same website that rembar pulled his) There are opposing viewpoints from scientists about fluoride and fluoridation. Rembar is being biased and choosing NOT to ackowledge these studies which prove that this video should be in the science channel. (whether he agrees with them or not is beside the point)

Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity.

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=9518651&dopt=AbstractPlus

Neurotoxicity of sodium fluoride in rats.

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=7760776&dopt=AbstractPlus

Fluoride deposition in the aged human pineal gland.

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=11275672&dopt=AbstractPlus

for those reading this thread, please do not be mislead by rembars assertion that there is no scientific evidence of fluoride being harmful. I only have to prove there is scientists and scientific evidence that says fluoride is harmful. I don't personally have to prove it.

one would assume that if the EPA was to look at the subject they would be studying and comparing scientific studies. So here are Excerpts from: “Fluoride in Drinking Water: A Scientific Review of EPA’s Standards” (National Research Council, 2006)

FLUORIDE’S EFFECTS ON THE BRAIN:

“On the basis of information largely derived from histological, chemical, and molecular studies, it is apparent that fluorides have the ability to interfere with the functions of the brain and the body by direct and indirect means.” p187

“A few epidemiologic studies of Chinese populations have reported IQ deficits in children exposed to fluoride at 2.5 to 4 mg/L in drinking water. Although the studies lacked sufficient detail for the committee to fully assess their quality and relevance to U.S. populations, the consistency of the results appears significant enough to warrant additional research on the effects of fluoride on intelligence.” p6

“histopathological changes similar to those traditionally associated with Alzheimer’s disease in people have been seen in rats chronically exposed to AlF.” p178

“Fluorides also increase the production of free radicals in the brain through several different biological pathways. These changes have a bearing on the possibility that fluorides act to increase the risk of developing Alzheimer’s disease.” p186

“More research is needed to clarify fluoride’s biochemical effects on the brain.” p186

“The possibility has been raised by the studies conducted in China that fluoride can lower intellectual abilities. Thus, studies of populations exposed to different concentrations of fluoride in drinking water should include measurements of reasoning ability, problem solving, IQ, and short- and long-term memory.” p187

“Studies of populations exposed to different concentrations of fluoride should be undertaken to evaluate neurochemical changes that may be associated with dementia. Consideration should be given to assessing effects from chronic exposure, effects that might be delayed or occur late-in-life, and individual susceptibility.” p187

“Additional animal studies designed to evaluate reasoning are needed.” p. 187

FLUORIDE’S EFFECTS ON THE ENDOCRINE SYSTEM:

“In summary, evidence of several types indicates that fluoride affects normal endocrine function or response; the effects of the fluoride-induced changes vary in degree and kind in different individuals. Fluoride is therefore an endocrine disruptor in the broad sense of altering normal endocrine function or response, although probably not in the sense of mimicking a normal hormone. The mechanisms of action remain to be worked out and appear to include both direct and indirect mechanisms, for example, direct stimulation or inhibition of hormone secretion by interference with second messenger function, indirect stimulation or inhibition of hormone secretion by effects on things such as calcium balance, and inhibition of peripheral enzymes that are necessary for activation of the normal hormone.” p223

“Some of these [endocrine] effects are associated with fluoride intake that is achievable at fluoride concentrations in drinking water of 4 mg/L or less, especially for young children or for individuals with high water intake. Many of the effects could be considered subclinical effects, meaning that they are not adverse health effects. However, recent work on borderline hormonal imbalances and endocrine-disrupting chemicals indicated that adverse health effects, or increased risks for developing adverse effects, might be associated with seemingly mild imbalances or perturbations in hormone concentrations. Further research is needed to explore these possibilities.” p7

“Further effort is necessary to characterize the direct and indirect mechanisms of fluoride’s action on the endocrine system and the factors that determine the response, if any, in a given individual.” p223

“The effects of fluoride on various aspects of endocrine function should be examined further, particularly with respect to a possible role in the development of several diseases or mental states in the United States.” p224

FLUORIDE’S EFFECTS ON THE THYROID:

“several lines of information indicate an effect of fluoride exposure on thyroid function.” p197

“it is difficult to predict exactly what effects on thyroid function are likely at what concentration of fluoride exposure and under what circumstances.” p197

“Fluoride exposure in humans is associated with elevated TSH concentrations, increased goiter prevalence, and altered T4 and T3 concentrations; similar effects on T4 and T3 are reported in experimental animals..” p218

“In humans, effects on thyroid function were associated with fluoride exposures of 0.05-0.13 mg/kg/day when iodine intake was adequate and 0.01-0.03 mg/kg/day when iodine intake was inadequate.” p218

“The recent decline in iodine intake in the United States (CDC 2002d; Larsen et al. 2002) could contribute to increased toxicity of fluoride for some individuals.” p218

“Intake of nutrients such as calcium and iodine often is not reported in studies of fluoride effects. The effects of fluoride on thyroid function, for instance, might depend on whether iodine intake is low, adequate, or high, or whether dietary selenium is adequate.” p222

FLUORIDE’S EFFECTS ON THE PINEAL GLAND:

“The single animal study of pineal function indicates that fluoride exposure results in altered melatonin production and altered timing of sexual maturity (Table 8-1). Whether fluoride affects pineal function in humans remains to be demonstrated. The two studies of menarcheal age in humans show the possibility of earlier menarche in some individuals exposed to fluoride, but no definitive statement can be made. Recent information on the role of the pineal organ in humans suggests that any agent that affects pineal function could affect human health in a variety of ways, including effects on sexual maturation, calcium metabolism, parathyroid function, postmenopausal osteoporosis, cancer, and psychiatric disease.” p221-22

FLUORIDE’S EFFECTS ON INSULIN SECRETION/DIABETES:

“The conclusion from the available studies is that sufficient fluoride exposure appears to bring about increases in blood glucose or impaired glucose tolerance in some individuals and to increase the severity of some types of diabetes. In general, impaired glucose metabolism appears to be associated with serum or plasma fluoride concentrations of about 0.1 mg/L or greater in both animals and humans. In addition, diabetic individuals will often have higher than normal water intake, and consequently, will have higher than normal fluoride intake for a given concentration of fluoride in drinking water. An estimated 16-20 million people in the U.S. have diabetes mellitus; therefore, any role of fluoride exposure in the development of impaired glucose metabolism or diabetes is potentially significant.” p. 217

FLUORIDE’S EFFECTS ON THE IMMUNE SYSTEM:

“Nevertheless, patients who live in either an artificially fluoridated community or a community where the drinking water naturally contains fluoride at 4 mg/L have all accumulated fluoride in their skeletal systems and potentially have very high fluoride concentrations in their bones. The bone marrow is where immune cells develop and that could affect humoral immunity and the production of antibodies to foreign chemicals.” p249

“There is no question that fluoride can affect the cells involved in providing immune responses. The question is what proportion, if any, of the population consuming drinking water containing fluoride at 4.0 mg/L on a regular basis will have their immune systems compromised? Not a single epidemiologic study has investigated whether fluoride in the drinking water at 4 mg/L is associated with changes in immune function. Nor has any study examined whether a person with an immunodeficiency disease can tolerate fluoride ingestion from drinking water.” p250

“bone concentrates fluoride and the blood-borne progenitors could be exposed to exceptionally high fluoride concentrations. Thus, more research needs to be carried out before one can state that drinking water containing fluoride at 4 mg/L has no effect on the immune system.” p250

“it is important to consider subpopulations that accumulate large concentrations of fluoride in their bones (e.g., renal patients). When bone turnover occurs, the potential exists for immune system cells and stem cells to be exposed to concentrations of fluoride in the interstitial fluids of bone that are higher than would be found in serum. From an immunologic standpoint, individuals who are immunocompromised (e.g., AIDS, transplant, and bone-marrow-replacement patients) could be at greater risk of the immunologic effects of fluoride.” p 258

“Within 250 ?m of a site of resorption, it is possible to encounter progenitor cells that give rise to bone, blood, and fat. Thus, one must assume that these cells would be exposed to high concentrations of fluoride. At this time, it is not possible to predict what effect this exposure would have on the functioning of skeletal elements, hematopoiesis, and adipose formation.” p115

“It is paramount that careful biochemical studies be conducted to determine what fluoride concentrations occur in the bone and surrounding interstitial fluids from exposure to fluoride in drinking water at up to 4 mg/L, because bone marrow is the source of the progenitors that produce the immune system cells.” p 259

“In addition, studies could be conducted to determine what percentage of immunocompromised subjects have adverse reactions when exposed to fluoride in the range of 1-4 mg/L in drinking water.” p259

FLUORIDE’S INTERACTIVE/SYNERGISTIC EFFECTS (w/ IODINE, ALUMINUM, ETC):

“Intake of nutrients such as calcium and iodine often is not reported in studies of fluoride effects. The effects of fluoride on thyroid function, for instance, might depend on whether iodine intake is low, adequate, or high, or whether dietary selenium is adequate.” p222

“Better characterization of exposure to fluoride is needed in epidemiology studies investigating potential effects. Important exposure aspects of such studies would include the following: collecting data on general dietary status and dietary factors that could influence exposure or effects, such as calcium, iodine, and aluminum intakes.” p72

“Available information now indicates a role for aluminum in the interaction of fluoride on the second messenger system; thus, differences in aluminum exposure might explain some of the differences in response to fluoride exposures among individuals and populations.” p222

“With the increasing prevalence of acid rain, metal ions such as aluminum become more soluble and enter our day-to-day environment; the opportunity for bioactive forms of AlF to exist has increased in the past 100 years. Human exposure to aluminofluorides can occur when a person ingests both a fluoride source (e.g., fluoride in drinking water) and an aluminum source; sources of human exposure to aluminum include drinking water, tea, food residues, infant formula, aluminum-containing antacids or medications, deodorants, cosmetics, and glassware.” p42

“Further research should include characterization of both the exposure conditions and the physiological conditions (for fluoride and for aluminum or beryllium) under which aluminofluoride and beryllofluoride complexes can be expected to occur in humans as well as the biological effects that could result.” p42

“Another possible explanation for increased blood lead concentrations which has not been examined is the effect of fluoride intake on calcium metabolism; a review by Goyer (1995) indicates that higher blood and tissue concentrations of lead occur when the diet is low in calcium. Increased fluoride exposure appears to increase the dietary requirement for calcium (see Chapter ; in addition, the substitution of tap-water based beverages (e.g., soft drinks or reconstituted juices) for dairy products would result in both increased fluoride intake and decreased calcium intake.” p43

“[G]iven the expected presence of fluoride ion (from any fluoridation source) and silica (native to the water) in any fluoridated tap water, it would be useful to examine what happens when that tap water is used to make acidic beverages or products (commercially or in homes), especially fruit juice from concentrate, tea, and soft drinks. Although neither Urbansky (2002) nor Morris (2004) discusses such beverages, both indicate that at pH < 5, SiF6 2- would be present, so it seems reasonable to expect that some SiF6 2- would be present in acidic beverages but not in the tap water used to prepare the beverages. Consumption rates of these beverages are high for many people, and therefore the possibility of biological effects of SiF62-, as opposed to free fluoride ion, should be examined.” p44
FLUORIDE’S EFFECTS ON THE REPRODUCTIVE SYSTEM:

“A few human studies suggested that high concentrations of fluoride exposure might be associated with alterations in reproductive hormones, effects on fertility, and developmental outcomes, but design limitations make those studies insufficient for risk evaluation.” p6

“the relationship between fertility and fluoride requires additional study.” p161

FLUORIDE & DOWNS SYNDROME:

“The possible association of cytogenetic effects with fluoride exposure suggests that Down’s syndrome is a biologically plausible outcome of exposure.” p170

“A reanalysis of data on Down’s syndrome and fluoride by Takahashi (1998) suggested a possible association in children born to young mothers. A case-control study of the incidence of Down’s syndrome in young women and fluoride exposure would be useful for addressing that issue. However, it may be particularly difficult to study the incidence of Down’s syndrome today given increased fetal genetic testing and concerns with confidentiality.” 172

FLUORIDE’S EFFECTS ON THE GASTROINTESTINAL SYSTEM:

“The numerous fluoridation studies in the past failed to rigorously test for changes in GI symptoms and there are no studies on drinking water containing fluoride at 4 mg/L in which GI symptoms were carefully documented.” p230

“GI effects appear to have been rarely evaluated in the fluoride supplement studies that followed the early ones in the 1950s and 1960s.” p231

“The table suggests that fluoride at 4 mg/L in the drinking water results in approximately 1% of the population experiencing GI symptoms.” p231

“Whether fluoride activates G proteins in the gut epithelium at very low doses (e.g., from fluoridated water at 4.0 mg/L) and has significant effects on the gut cell chemistry must be examined in biochemical studies.” p236

“There are a few case reports of GI upset in subjects exposed to drinking water fluoridated at 1 mg/L. Those effects were observed in only a small number of cases, which suggest hypersensitivity. However, the available data are not robust enough to determine whether that is the case.” p. 250

“Studies are needed to evaluate gastric responses to fluoride from natural sources at concentrations up to 4 mg/L and from artificial sources.” p. 258

FLUORIDE’S EFFECTS ON THE LIVER:

“It is possible that a lifetime ingestion of 5-10 mg/day from drinking water containing 4 mg/L might turn out to have long-term effects on the liver, and this should be investigated in future epidemiologic studies.” p248

“The effect of low doses of fluoride on kidney and liver enzyme functions in humans needs to be carefully documented in communities exposed to different concentrations of fluoride in drinking water.” p258

FLUORIDE’S EFFECTS ON THE KIDNEY:

“Human kidneys... concentrate fluoride as much as 50-fold from plasma to urine. Portions of the renal system may therefore be at higher risk of fluoride toxicity than most soft tissues.” p236

“Early water fluoridation studies did not carefully assess changes in renal function.” p236

“future studies should be directed toward determining whether kidney stone formation is the most sensitive end point on which to base the MCLG.” p247

“On the basis of studies carried out on people living in regions where there is endemic fluorosis, ingestion of fluoride at 12 mg per day would increase the risk for some people to develop adverse renal effects.” p247

“The effect of low doses of fluoride on kidney and liver enzyme functions in humans needs to be carefully documented in communities exposed to different concentrations of fluoride in drinking water.” p258

FLUORIDE & CANCER:

“Fluoride appears to have the potential to initiate or promote cancers, particularly of the bone, but the evidence to date is tentative and mixed (Tables 10-4 and 10-5). As noted above, osteosarcoma is of particular concern as a potential effect of fluoride because of (1) fluoride deposition in bone, (2) the mitogenic effect of fluoride on bone cells, (3) animal results described above, and (4) pre-1993 publication of some positive, as well as negative, epidemiologic reports on associations of fluoride exposure with osteosarcoma risk.“ p. 286

“Because fluoride stimulates osteoblast proliferation, there is a theoretical risk that it might induce a malignant change in the expanding cell population. This has raised concerns that fluoride exposure might be an independent risk factor for new osteosarcomas.” p109

“Osteosarcoma presents the greatest a priori plausibility as a potential cancer target site because of fluoride’s deposition in bone, the NTP animal study findings of borderline increased osteosarcomas in male rats, and the known mitogenic effect of fluoride on bone cells in culture (see Chapter 5). Principles of cell biology indicate that stimuli for rapid cell division increase the risks for some of the dividing cells to become malignant, either by inducing random transforming events or by unmasking malignant cells that previously were in nondividing states.” p275

“Further research on a possible effect of fluoride on bladder cancer risk should be conducted.” p288