CRISPR-Cas9 ("Mr. Sandman" Parody) | A Capella Science

This is without a doubt the most entertaining A Capella Science song yet.

The song assumes you already know about Crispr-Cas9, so it never actually explains that it's a targeted gene editing technique which is cheaper, faster, and more effective than any previous techniques used by microbiologists. As mentioned in the song, it was originally discovered by Swedish researchers working with the nasty flesh-eating bacteria Streptococcus pyogenes. Alternatively you could say it was originally discovered by the bacteria.

Overview by Wired (link pinched from the first vid in the playlist below): http://bit.ly/1DuM4zq

(H/T @eric3579)

YouTube description:

POSTER: http://store.dftba.com/products/bohemian-gravity-poster
SUBSCRIBE: https://www.youtube.com/user/acapellascience?sub_confirmation=1
MP3: https://timblais.bandcamp.com/track/crispr-cas9-bring-me-a-gene

---END SCREEN LINKS---

"MAKING OF" PRODUCTION TUTORIAL: https://youtu.be/KcehlTQs1og
CRISPR PLAYLIST: https://youtu.be/jAhjPd4uNFY?list=PLboc_P9zcJhjXdwmsdo6_Z5c1lXbRI2GF
JOE HANSON: https://youtu.be/VTUCTT6I1TU
TOM ZALATNAI: https://youtu.be/Osiql2-TwH4

-----LYRICS-----

READ LYRICS HERE: https://timblais.bandcamp.com/track/crispr-cas9-bring-me-a-gene
siftbotsays...

Promoting this video and sending it back into the queue for one more try; last queued Saturday, October 8th, 2016 7:52pm PDT - promote requested by eric3579.

eric3579says...

CRISPR-Cas9
Bring me a gene
Encoding for a specific protein
Make a few snips at this coded locus
You work so well inside a streptococcus
Cas9
I'm so alone
Without your scissors in my chromosome
Cut me up and do it clean
CRISPR-Cas9 bring me a gene

CRISPR-Cas9
Keep me a gene
A viral sequence you've already seen
Chopped into bits and stored as genomic
With clustered repeats
That are palindromic
Cas9
Bind with this code
Use it to target infections of old
Immunized like a vaccine
CRISPR-Cas9 keep me a gene

CRISPR-Cas9
Cut me a gene
With a precision that I've never seen
Unzip a strand and interrogate it
Seek out your sequence until you locate it
Cas9
Lock into place
And do your job as endonuclease
Chop just like a guillotine
CRISPR-Cas9 cut me a gene

Snip snap!
CRISPR-Cas9
CRISPR-Cas9

CRISPR-Cas9
Bring me a gene
By commandeering my repair routine
A strand to match your severed location
For some homologous recombination
Cas9
Cheap and precise
Rewriting genomes from microbes to mice
And soon the humble human being
CRISPR-Cas9 bring me a gene

CRISPR-Cas9
Give us a gene
Give us a miracle like that one Nazarene
‘Cause giving the lame their legs and the blind their sight is
In view for dystrophy and retinitis
But CRISPR-Cas9
What if you fall
Outside our power and inside us all
That really could incite a scene

When this terrible wonderful power unsettling
Opens the door to unethically meddle
Is ev’ry congenital malady bettered
Sufficient to warrant genetics unfettered
To modify man in the manner of Gattaca
Raise up a mammoth or make a rattata
Dramatical medical means to eradicate aging
Or cancer or make a fanatic
A mass epidemic a weapon nefarious
Single mosquito to wipe out malaria
Send in a viral infection to ferry a
Cure to the cells of an HIV carrier
Freed of disease as we're free to uncover
What nature and accident failed to discover
And free to be other than
All that we ever have been

CRISPR-Cas9
CRISPR-Cas9

Oh CRISPR-Cas9
Bring us a gene
You wondrous ribonucleoprotein
You have the power to vanquish or save us
Who would have thought that the microbe that gave us
Cas9
S. pyogenes
The source of strep and flesh-eating disease
Housed this marvellous machine
Full of uses great and obscene
CRISPR-Cas9 bring us
Please don't sting us
Cas9 bring us a gene

With adenine
And thiamine
Incite a scene
Cas9 bring us a gene!

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