CBD possesses sedative properties (Carlini and Cunha, 1981), and a clinical
trial showed that it reduces the anxiety and other unpleasant psychological
side effects provoked by pure THC (Zuardi et al. 1982). CBD modulates the
pharmacokinetics of THC by three mechanisms: (1) it has a slight affinity for
cannabinoid receptors (Ki at CB1 = 4350 nM, compared to THC = 41 nM,
Showalter et al. 1996), and it signals receptors as an antagonist or reverse agonist
(Petitet et al. 1998), (2) CBD may modulate signal transduction by perturbing
the fluidity of neuronal membranes, or by remodeling G-proteins that
carry intracellular signals downstream from cannabinoid receptors, and (3)CBD
is a potent inhibitor of cytochrome P450 3A11 metabolism, thus it blocks the
hydroxylation of THC to its 11-hydroxy metabolite (Bornheim et al. 1995).
The 11-hydroxy metabolite is four times more psychoactive than unmetabolized
THC (Browne and Weissman 1981), and four times more immunosuppressive
(Klein et al. 1987).
CBD provides antipsychotic benefits (Zuardi et al. 1995). It increases dopamine
activity, serves as a serotonin uptake inhibitor, and enhances norepinephrine
activity (Banerjee et al. 1975; Poddar and Dewey 1980). CBD protects
neurons from glutamate toxicity and serves as an antioxidant, more potently
than ascorbate and α-tocopherol (Hampson et al. 1998). Auspiciously, CBD
does not decrease acetylcholine (ACh) activity in the brain (Domino 1976;
Cheney et al. 1981). THC, in contrast, reduces hippocampal ACh release in
rats (Carta et al. 1998), and this correlates with loss of short-term memory consolidation.
In the hippocampus THC also inhibits N-methyl-D-aspartate (NMDA)
receptor activity (Misner and Sullivan 1999; Shen and Thayer 1999), and
NMDA synaptic transmission is crucial for memory consolidation (Shimizu et
al. 2000). CBD, unlike THC, does not dampen the firing of hippocampal cells
(Heyser et al. 1993) and does not disrupt learning (Brodkin and Moerschbaecher
1997).
Consroe (1998) presented an excellent review of CBD in neurological disorders.
In some studies, it ameliorates symptoms of Huntington’s disease, such
as dystonia and dyskinesia. CBD mitigates other dystonic conditions, such as
torticollis, in rat studies and uncontrolled human studies. CBD functions as an
anticonvulsant in rats, on a par with phenytoin (Dilantin, a standard antiepileptic
drug).
CBD demonstrated a synergistic benefit in the reduction of intestinal motility
in mice produced by THC (Anderson, Jackson, and Chesher 1974). This
may be an important component of observed benefits of cannabis in inflammatory
bowel diseases.

--"Cannabis and Cannabis Extracts:
Greater Than the Sum of Their Parts?
John M. McPartland
Ethan B. Russo"

I think the big guns is droning Abdulrahman Anwar Al-Awlaki, the 16 year old son of Anwar Al-Awlaki. Born in Denver in 1995, an American citizen was killed by a drone while he searched for his recently droned father in the desert in Yemen where we are not at war. The teenager could only be identified by a piece of his skull which had his hair on it.

Robert Gibbs, Obamas former Press Secretary justified it by saying the boy "should [have] had a more responsible father."

Fuck Obama.

Your video, "Stand By Your Man" - (Banned Guinness Commercial, 1995), has made it into the Top 15 New Videos listing. Congratulations on your achievement. For your contribution you have been awarded 1 Power Point.

$90k on a commuter car is a tough sell. My Tesla would be getting beat up in the lot at work all week, and I'd be making the 2-hour trip home to see my parents in a 1995 Hyundai Accent.

I can only hope Tesla survives long enough to have an impact on the real-world car market. Having a large company doing/driving battery R&D is also a good thing for all sorts of markets.

It is a common fantasy that gun bans make society safer. In 2002 -- five years after enacting its gun ban -- the Australian Bureau of Criminology acknowledged there is no correlation between gun control and the use of firearms in violent crime. In fact, the percent of murders committed with a firearm was the highest it had ever been in 2006 (16.3 percent), says the D.C. Examiner.

Even Australia's Bureau of Crime Statistics and Research acknowledges that the gun ban had no significant impact on the amount of gun-involved crime...

Moreover, Australia and the United States -- where no gun-ban exists -- both experienced similar decreases in murder rates:

* Between 1995 and 2007, Australia saw a 31.9 percent decrease; without a gun ban, America's rate dropped 31.7 percent.
* During the same time period, all other violent crime indices increased in Australia: assault rose 49.2 percent and robbery 6.2 percent.
* Sexual assault -- Australia's equivalent term for rape -- increased 29.9 percent.
* Overall, Australia's violent crime rate rose 42.2 percent.
* At the same time, U.S. violent crime decreased 31.8 percent: rape dropped 19.2 percent; robbery decreased 33.2 percent; aggravated assault dropped 32.2 percent.
* Australian women are now raped over three times as often as American women.
More...

I am thoroughly enjoying my ability to use the related tag haha
http://videosift.com/video/The-Internet-circa-1995-Dial-up-Pentiums-Giant-CRTs-FTP

*related=http://videosift.com/video/The-Internet-circa-1995-Dial-up-Pentiums-Giant-CRTs-FTP

The Internet circa 1995. Dial up, Pentiums, Giant CRTs, FTP has been added as a related post - related requested by braschlosan.

*related=http://videosift.com/video/The-Internet-circa-1995-Dial-up-Pentiums-Giant-CRTs-FTP

The Internet circa 1995. Dial up, Pentiums, Giant CRTs, FTP has been added as a related post - related requested by braschlosan.

*related=http://videosift.com/video/The-Internet-circa-1995-Dial-up-Pentiums-Giant-CRTs-FTP

The Internet circa 1995. Dial up, Pentiums, Giant CRTs, FTP has been added as a related post - related requested by braschlosan.

*related=http://videosift.com/video/The-Internet-circa-1995-Dial-up-Pentiums-Giant-CRTs-FTP

The Internet circa 1995. Dial up, Pentiums, Giant CRTs, FTP has been added as a related post - related requested by braschlosan.

*related=http://videosift.com/video/The-Internet-circa-1995-Dial-up-Pentiums-Giant-CRTs-FTP