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The Vitamin D Paradox in COVID-19

newtboy says...

So if you synthesize your own through exposure to sunlight, you’re good? Or at least better off?
Is it possible that it’s not the delivery method, but the systems that use vitamin D being healthy beforehand vs being supplemented after the fact? Maybe it takes a while to get those systems healthy, and supplements don’t help with that.

Edit: Maybe, since the same receptors are used to metabolize vitamin D as to infect a cell with covid, those receptors being “full” might be what’s stopping infections, and dosing with vitamin D after infection doesn’t magically replace the Covid with vitamin D? Not really about vitamin D or why you need it, just about the mechanism the body uses to use the vitamin D? Biology is intricate, and why things work and how is not always clean and simple.

Melatonin? Then why aren’t people with more melatonin, people of color, nearly immune? Why are island nations like the Virgin Islands still having outbreaks today? Why were Southern states hit just as hard or harder than northern states? Many questions here.

His explanation seems to confirm this. If your cells produce vitamin D efficiently, they are less prone to infections, if you artificially add artificial vitamin D, it helps with the cellular functions, but the processes that should be producing it are still suppressed, possibly more because your body isn’t triggering them due to low vitamin D levels. It’s less about overall vitamin D levels than about having healthy systems that properly produce and utilize it….at least that’s my takeaway.

It’s not just about sunlight..it’s about diet, overall health, sleep, etc. biology is complex, and we always want a simple solution. There isn’t one most of the time, and our attempts to simplify only make things worse. Eat well, sleep well, get some sun, get some exercise, and you’ll be as safe as you can be naturally….then try supplements in addition, not instead.

I get plenty of sun, and my windows are from the 50’s. It definitely makes me feel better to get sun, but there’s a limit. Don’t just go sunbathe in Arizona, use your brain.

Man Derails Train Trying To Hit Hospital Ship

newtboy says...

According to my right wing cousin who believes the craziest conspiracy theories, Coronavirus is caused by 5G cellular signals.

Capitalism Didn’t Make the iPhone, You iMbecile

vil says...

1) no, trading is not capitalism.
2) kids in China did not - that is borderline silly. Creating and marketing the iphone created a DEMAND, the MARKET had been in place already (the US constitution, the fed, the dollar, cellular infrastructure, people free to buy things of their own will, the internet et cetera et cetera et cetera ad nauseam - takes a lot of preconceptions to be able to sell such a product)
3) basically yes.
4) I am sure we agree on a lot of things, this is one.
5) I understand government=socialism. The government of the US of A funds a lot of things that would be hard to justify as socialism. Maybe an argument can be made that basic research is a social investment IDK.

Basic research does not equal fast progress though. You can be as clever as Archimedes or Leonardo but steam trains require capitalism to make sense. Iphones required masses of rich crazy americans to take off - a market and demand. Without a market and demand (or a war) progress is slow as f***.

newtboy said:

1) Capitalism has been a thing since before writing was a thing.

2) kids in China made the Iphones, which created a smart phone market.

3) do you believe capitalism and the industrial revolution started at the same time.

4) Capitalism says your poor neighbors should die.

5) The government paid ...socialism, progress.

Powering the Cell: Mitochondria

acampos says...

The idea behind this animation is to help students think and learn about the process of Oxidative Phosphorylation. That is why the video doesn’t have any explanation. We, in the classroom (General biology, biochemistry, microbiology and others), study cellular respiration and watch the video. Unfortunately, many students will search the internet to get the “correct explanation” rather that study and think as an attempt to get an A in the assignment. So, explanations like this do not really help the educational system not only because they are not precise (many mistakes and misinterpretations can be found) but also because it encourages students to cheat in their assignments. Wouldn’t be better to ask people to study rather than tell them what they are watching?

Mordhaus (Member Profile)

Vantablack can make a flat disk of aluminium float on water

ForgedReality says...

I really doubt this would be considered safe enough to put into something for consumer production like a cell phone. It's made of carbon nanotubes. Those get into the air, and it's very, very toxic to breathe. It is like needles stabbing and slicing through your cellular membranes. There are some real concerns about the long-term safety of CNT. I would feel very unsafe having to work with it every day.

newtboy said:

I think some of the new waterproof phones might be using the coatings as one level of protection against water intrusion. Anything in a marine environment could also benefit.

The Trouble with Transporters

Curious says...

There have been many things in history that have been thought to have been impossible. Neil deGrasse Tyson's presentation on "The God of the Gaps" is a great video addressing that line of thought.

However, that point may not even matter. My hypothesis is that our neurons don't operate all the way down to a sub-atomic or electron-spin level of granularity. There's plenty of complexity at the molecular and cellular scales. We're likely chemical and physical reactions like Newtboy says.

robbersdog49 said:

Except that you can't know all the properties of those atoms all at once. The Uncertainty Principle shows there is a fundamental limit to what we can know about particles. An exact replication would be impossible.

Kids Getting A Nice View Of The Milf Neighbor's Breasts

Payback says...

I was going by this: http://www.coloribus.com/adsarchive/tv-commercials/stratos-the-woman-next-door-162405/

My bad. They're obviously fucked up. The song was recorded in the late 90s as well.

Although cordless phones were developed in the 60s, the kids are using an obviously 80s version. The first true Cellular phone was 1973 by Motorola, so I thought it possible.

Stratos seems to like making commercials with sexual innuendo.
http://videosift.com/video/What-ya-do-when-you-need-another-player-Make-a-baby

newtboy said:

Good catch. I just cut and pasted YT description, but will fix.

D'oh. You got me. That cordless phone would have been rotary back then. Changing it back....you bastard.

Oh my god

Trancecoach says...

Reminds me of the time that I observed an old woman walking home from the grocery store, who tripped and fell on her face as I drove by. Blood streamed from her face as I immediately pulled over to the side of the road and ran to her aid. I shouted at the bystanders to go get some towels to stem the bleeding as I checked to see if she was okay and called for help on my (at the time, fairly rare) cellular phone.

She asked me not to call the police, but to call her son-in-law, instead. She gave me the number and he came in about 10 minutes, as I sat by her side, helped to calm her jittery nerves and ensure that she was alright.

Three years later, she called me at random to thank me for my kindness. It was the least I could do and was surprising that so few people would have done likewise.

newtboy said:

You remind me of the time my grandmother, at 91 years old, was walking her small dog on Memorial Drive in Houston (MAJOR street, up to hundreds of cars per minute). She tripped on a crack in the sidewalk and fell hard on her face, smashing it badly and knocking out some teeth. She ended up crawling well over 2 blocks on hands and knees in full view of the street (no bushes or trees obstructing the view), bleeding profusely down her face, and not a single car stopped to help. That was over 6 years ago, and it still boils my blood that so many people are so uncaring/unhelpful, and it makes me think these are likely the same people that beg for help at the slightest discomfort in their own lives.
Sometimes I just hate humans.

Insane Amount Of Fireworks

00Scud00 says...

Nah, much too small for Bay, he doesn't bother with anything less than 1000lbs.
Also reminds me why I always used Cellular Ammunition Storage Equipment if possible when playing Mechwarrior.

sixshot said:

It's like Michael Bay's wet dream intensified by 1000.

3 seconds cooking!!

Brittany Maynard - Death with Dignity

Sniper007 says...

TONS of things cure cancer. All day, every day. Doctors have no clue what cancer is. All they can do is cut, burn, or poison and cross their fingers.

I didn't say Cannabis was THE cure. It is A cure used by thousands with amazing efficacy. Everyone is different.

Here's 60+ studies for your perusal if you insist on the superiority of western scientific research:

"Cannabis, and the cannabinoid compounds found within it, has been shown through a large cannabisplantamount of scientific, peer-reviewed research to be effective at treating a wide variety of cancers, ranging from brain cancer to colon cancer. Below is a list of over 60 studies that demonstrate the vast anti-cancer properties of cannabis.
Studies showing cannabis may combat brain cancer:
Cannabidiol (CBD) inhibits the proliferation and invasion in U87-MG and T98G glioma cells. Study published in the Public Library of Science journal in October 2013.
Tetrahydrocannabinol (THC) can kill cancer cells by causing them to self-digest. Study published in the Journal of Clinical Investigation in September 2013.
CBD is a novel therapeutic target against glioblastoma. Study published in Cancer Research in March 2013.
Local delivery of cannabinoid-filled microparticles inhibits tumor growth in a model of glioblastoma multiforme. Study published in Public Library of Science in January 2013.
Cannabinoid action inhibits the growth of malignant human glioma U87MG cells. Study published in Oncology Reports in July 2012.
Cannabidiol enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival. Study published in the Molecular Cancer Therapeutics journal in January 2010.
Cannabinoid action induces autophagy-mediated cell death in human glioma cells. Study published in The Journal of Clinical Investigation in May 2009.
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Study published in Cancer Research in March 2008.
Cannabinoids and gliomas. Study published in Molecular Neurobiology in June 2007.
Cannabinoids inhibit gliomagenesis. Study published in the Journal of Biological Chemistry in March 2007.
A pilot clinical study of THC in patients with recurrent glioblastoma multiforme. The results were published in the British Journal of Cancer in June 2006.
Cannabidiol inhibits human glioma cell migration through an independent cannabinoid receptor mechanism. Study published in the British Journal of Pharmacology in April 2005.
Cannabinoids inhibit the vascular endothelial growth factor pathway (VEGF) in gliomas. Study published in the Journal of Cancer Research in August 2004.
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. Study published in the Journal of Pharmacology in November 2003.
Inhibition of glioma growth in vivo by selective activation of the CB2 cannabinoid receptor. Study published in the Journal of Cancer Research in August 2001.
Studies showing cannabis may combat colorectal cancer:
Cannabigerol (CBG) can inhibit colon cancer cells. Study published in the Oxford journal Carcinogenesis in October 2014.
Inhibition of colon carcinogenesis by a standardised Cannabis Sativa extract with high content of CBD. Study published in Phytomedecine in December 2013.
Chemopreventive effect of the non-psychotropic phytocannabinoid CBD on colon cancer. Study published in the Journal of Molecular Medecine in August 2012.
Cannabinoids against intestinal inflammation and cancer. Study published in Pharmacology Research in August 2009.
Action of cannabinoid receptors on colorectal tumor growth. Study published by the Cancer Center of the University of Texas in July 2008.
Studies showing cannabis may combat blood cancer:
The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. Study published in the International Journal of Cancer in December 2013.
Enhancing the activity of CBD and other cannabinoids against leukaemia. Study published in Anticancer Research in October 2013.
Cannabis extract treatment for terminal acute lymphoblastic leukemia of Philadelphia chromosome (Ph1). Study published in Case Reports in Oncology in September 2013.
Expression of type 1 and type 2 cannabinoid receptors in lymphoma. Study published in the International Journal of Cancer in June 2008.
Cannabinoid action in mantle cell lymphoma. Study published in Molecular Pharmacology in November 2006.
THC-induced apoptosis in Jurkat leukemia. Study published in Molecular Cancer Research in August 2006.
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Study published in Blood American Society of Hemmatology in July 2002.
Studies showing cannabis can combat lung cancer:
Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of Icam-1. Study published in Biochemical Pharmacology in July 2014.
Cannabinoids inhibit angiogenic capacities of endothelial cells via release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells. Study published in Biochemical Pharmacology in June 2014.
COX-2 and PPAR-γ confer CBD-induced apoptosis of human lung cancer cells. Study published in Molecular Cancer Therapeutics in January 2013.
CBD inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. Study published in the Journal of the Federation of American Societies for Experimental Biology in April 2012.
Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non–small cell lung cancer growth and metastasis. Study published in Cancer Prevention Research in January 2011.
THC inhibits epithelial growth factor-induced (EGF) lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Study published in the journal Oncogene in July 2007.
Studies showing cannabis may combat stomach cancer:
Cannabinoid receptor agonist as an alternative drug in 5-Fluorouracil-resistant gastric cancer cells. Study published in Anticancer Research in June 2013.
Antiproliferative mechanism of a cannabinoid agonist by cell cycle arrest in human gastric cancer cells. Study published in the Journal of Cellular Biochemistry in March 2011.
Studies showing cannabis may combat prostrate cancer:
Cannabinoids can treat prostate cancer. Study published by the National Institute of Health in October 2013.
Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms. Study published in the British Journal of Pharmacology in December 2012.
The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications. Study published in the Indian Journal of Urology in January 2012.
Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent. Study published in Anticancer Research in November 2011.
Studies showing cannabis may combat liver cancer:
Involvement of PPARγ in the antitumoral action of cannabinoids on hepatocellular carcinoma (CHC). Study published in Cell Death and Disease in May 2013.
Evaluation of anti-invasion effect of cannabinoids on human hepatocarcinoma cells. Study published on the site Informa Healthcare in February 2013.
Antitumoral action of cannabinoids on hepatocellular carcinoma. Study published in Cell Death and Differentiation in April 2011.
Studies showing cannabis may combat pancreatic cancer:
Cannabinoids inhibit energetic metabolism and induce autophagy in pancreatic cancer cells. Study published in Cell Death and Disease in June 2013.
Cannabinoids Induce apoptosis of pancreatic tumor cells. Study published in Cancer Research in July 2006.
Studies showing cannabis may combat skin cancer:
Cannabinoid receptor activiation can combat skin cancer. Study published by the National Institute of Health in October 2013.
Cannabinoids were found to reduce skin cancer by 90% in just 2 weeks. Study published in the Journal of Pharmacy and Pharmacology in July 2013.
Cannabinoid receptors as novel targets for the treatment of melanoma. Study published in the Journal of the Federation of American Societies for Experimental Biology in December 2006.
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. Study published in the Journal of Clinical Investigation, in January 2003.
Studies showing cannabis may combat other types of cancer:
Bladder: Marijuana reduces the risk of bladder cancer. Study published in the Medscape site in May 2013.
Kaposi sarcoma: Cannabidiol inhibits growth and induces programmed cell death in Kaposi sarcoma–associated herpesvirus-infected endothelium. Study published in the journal Genes & Cancer in July 2012.
Nose, mouth, throat, ear: Cannabinoids like THC inhibit cellular respiration of human oral cancer cells. Study by the Department of Pediatrics at the State University of New York, published in June 2010.
Bile duct: The dual effects of THC on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration. Study published in Cancer Investigation in May 2010.
Ovaries: Cannabinoid receptors as a target for therapy of ovarian cancer. Study published on the American Association for Cancer Research website in 2006.
Preparation and characterisation of biodegradable microparticles filled with THC and their antitumor efficacy on cancer cell lines. Study published in the Journal of Drug Targeting in September 2013.
CBD Cannabidiol as a potential anticancer drug. Study published in the British Journal of Pharmacology in February 2013.
Cannabinoids as anticancer modulators. Study published in the Progress in Lipid Research journal in January 2013.
CBD inhibits angiogenesis by multiple mechanisms. Study published in the British Journal of Pharmacology in November 2012.
Towards the use of cannabinoids as antitumour agents. Study published in Nature in June 2012.
Cannabinoid-associated cell death mechanisms in tumor models. Study published in the International Journal of Oncology in May 2012.
Cannabinoids, endocannabinoids and cancer. Study published in Cancer Metastasis Reviews in December 2011.
The endocannabinoid system and cancer: therapeutic implication. Study published in the British Journal of Pharmacology in July 2011.
This list was compiled in part by Alchimiaweb.com.
– TheJointBlog"

ChaosEngine said:

No, you'd be remiss if you opined blatant misinformation.

While there is a possibility that cannabinoids can inhibit tumour growth, there is nothing even close to a solid evidence base to show that "cannabis cures cancer".

Neil deGrasse Tyson schooling ignorant climate fools

chingalera says...

Oh and, nice holier-than-thou title for an homage to sucking DeGrasse Tyson-san's dick this Science-Friday there, Professor Chaos , two thumbs down on your cellular device while driving....

Tailgating is bad, okay!

chingalera says...

Correct. Tailgating combined with an inordinate amount of meatbots on their cellular devices divided by an inordinate and ever-increasing amount of people who should not be driving given their lack of ability to do so without endangering lives anyhow because of the fact that THEY NEVER SHOULD HAVE BEEN ALLOWED TO FUCKING DRIVE ANYHOW given their lack of awareness/motor skills/etc., makes city roadways of today a very annoying place.

Payback said:

The fisheye camera makes it look like he's got any room, but he's about one car length away from the Peugeot, at freeway speed. That's tailgating.

Kevin O'Leary on global inequality: "It's fantastic!"

direpickle says...

@Trancecoach: We're not going to agree, and that's fine. This'll be my last reply.

Retailer strong-arming: Imagine Apple makes up 95% of Best Buy's tablet sales. Off-brand-X wants to sell tablets at Best Buy. Apple says: If you sell Off-brand-X tablets, we will not let you sell our tablets. Off-brand-X is likely to only provide a tiny profit to Best Buy, compared to Apple, so they comply. (This actually happened, in a different form, with Intel paying computer manufacturers to not use AMD processors. See here). Also see price-fixing.

Widget-distribution-prevention: This is just an extension of the previous point.

Buying up all of the competitors: Ma Bell. Old AT&T. That should be enough said. But, if that's not enough, now Ma Bell is nearly entirely re-formed. The US was one government approval away from having cell carriers limited to Sprint, Verizon, and AT&T. That's been spoiled, now, but I don't think it's hard to imagine that future continuing on to two carriers colluding and price-fixing (as Verizon and AT&T pretty much have freedom to do anyway). This is another quasi-natural-monopoly situation (or at least a tragedy of the commons situation), in that the radio spectrum is not infinite. To keep the spectrum usable at all, blocks of frequencies are doled out to radio/TV/cellular/military/etc. etc. with stiff penalties for interference.

Patents: Patents present a litany of problems, but the world without them is even worse. You have two things happen, both of which are bad:
1) New technology remains veiled in secrecy indefinitely; no one else can riff on it even after patents would normally have expired
2) My previous point. The marginal utility of R&D decreases drastically based on the likelihood of a competitor being able to get hold of your secrets before you can profit on them sufficiently.
This is exactly why patents were created. It's a temporary monopoly granted by the government in exchange for the promise that the knowledge will be released to the universe after X years.

Predatory pricing: If excessive, it's illegal. That's why it doesn't happen very often. In a country with anti-trust laws, you just want to hurt your competitor, you don't want to drive them out of the market.

Natural monopolies: Since you brought this one up, you can choose your energy service because the government forces the utility to lease its lines and to decouple distribution from production. That is to say, you have a free market in production because the distribution is not free. See here. My state is the same way.

Misinformation: Who vets marketing claims in a free market? My competitor says that their food is organic. Well--hell, so is mine! They're environmentally conscientious? So am I! Their drug cures cancer? Mine cures it even better!

Oh, shit. Someone caught me in a lie! Well, I'll just force the media to ignore it and ramp up my disinformation campaign.



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