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shagen454 (Member Profile)

Cows Stranded After New Zealand 7.8 Earthquake

CRISPR-Cas9 ("Mr. Sandman" Parody) | A Capella Science

eric3579 says...

CRISPR-Cas9
Bring me a gene
Encoding for a specific protein
Make a few snips at this coded locus
You work so well inside a streptococcus
Cas9
I'm so alone
Without your scissors in my chromosome
Cut me up and do it clean
CRISPR-Cas9 bring me a gene

CRISPR-Cas9
Keep me a gene
A viral sequence you've already seen
Chopped into bits and stored as genomic
With clustered repeats
That are palindromic
Cas9
Bind with this code
Use it to target infections of old
Immunized like a vaccine
CRISPR-Cas9 keep me a gene

CRISPR-Cas9
Cut me a gene
With a precision that I've never seen
Unzip a strand and interrogate it
Seek out your sequence until you locate it
Cas9
Lock into place
And do your job as endonuclease
Chop just like a guillotine
CRISPR-Cas9 cut me a gene

Snip snap!
CRISPR-Cas9
CRISPR-Cas9

CRISPR-Cas9
Bring me a gene
By commandeering my repair routine
A strand to match your severed location
For some homologous recombination
Cas9
Cheap and precise
Rewriting genomes from microbes to mice
And soon the humble human being
CRISPR-Cas9 bring me a gene

CRISPR-Cas9
Give us a gene
Give us a miracle like that one Nazarene
‘Cause giving the lame their legs and the blind their sight is
In view for dystrophy and retinitis
But CRISPR-Cas9
What if you fall
Outside our power and inside us all
That really could incite a scene

When this terrible wonderful power unsettling
Opens the door to unethically meddle
Is ev’ry congenital malady bettered
Sufficient to warrant genetics unfettered
To modify man in the manner of Gattaca
Raise up a mammoth or make a rattata
Dramatical medical means to eradicate aging
Or cancer or make a fanatic
A mass epidemic a weapon nefarious
Single mosquito to wipe out malaria
Send in a viral infection to ferry a
Cure to the cells of an HIV carrier
Freed of disease as we're free to uncover
What nature and accident failed to discover
And free to be other than
All that we ever have been

CRISPR-Cas9
CRISPR-Cas9

Oh CRISPR-Cas9
Bring us a gene
You wondrous ribonucleoprotein
You have the power to vanquish or save us
Who would have thought that the microbe that gave us
Cas9
S. pyogenes
The source of strep and flesh-eating disease
Housed this marvellous machine
Full of uses great and obscene
CRISPR-Cas9 bring us
Please don't sting us
Cas9 bring us a gene

With adenine
And thiamine
Incite a scene
Cas9 bring us a gene!

What The Truman Show Teaches Us About Politics

poolcleaner says...

Is the name of the town of Seahaven a reference to the Sweethaven from Popeye the movie:

Sweet Sweethaven
God must love us
We the people
Love Sweethaven
Hurray hurray Sweethaven
Flags are wavin'
Swept people from the sea
Safe from democracy
Sweeter than a melon tree
Put here for you and me

Sweethaven
Sweet Sweethaven
God must love us
We the people
Of Sweethaven
God must have landed here
Why else would he strand us here
Where the air is nice and clear
Sweethaven even sounds so near
To Heaven

God will always bless Sweethaven
God will always bless Sweethaven
God will always bless Sweethaven

Jim Jefferies on Bill Cosby and Rape Jokes

Chairman_woo says...

I fear you have misunderstood what I was getting at.

He talks for full minute about the ironic idea of the victims hypothetically having a sense of cognitive dissonance about the experience (done from his perspective).

Timestamp: 3:40ish to 4:50ish

I don't for a moment think he is suggesting they actually did, but the juxtaposition of that can be funny for the reasons I already outlined.
i.e. it is a common phenomenon in other areas of our experience, with people we idolise. By associating it with an experience in which we presume most people wouldn't or didn't feel that way, we have more strings of that irony thrown into the comedy orchestra.

Cosby is famous and loved and his fans presumably find him funny. There is therefore humour in the ridiculous idea that there might be some starstruck joy in being violated by said idol.

I think the bit worked perfectly if one can detach oneself from ideological prejudices.

As I already said, Louis's bits about paedophilia don't appear to be doing anything different here and thus far you have failed to explain how they actually differ, other than using the unqualified term "truthful".

Louis talks about their desires and relates them in a way universal to the human condition. This is precisely what much of Jim routine is clearly doing. "think about the thing you really love to do, well that's how Bill feels about rape" (paraphrased).

I can't see a distinction right now other than you appear to be much more emotionally sensitive to the rape thing. This is understandable, but I'm not seeing the lack of equivalence between the two comics here in terms of composition and implied meaning?

This whole bit felt deeply multi stranded and was tackling many disparate concepts at once. The gradation of rape was merely one of them and I think it's unfair to break it down to only one, or to deny the "truthfulness" hiding behind the sham.

Without that "truthfulness" the whole bit doesn't work, the assumption that the audience recognises the reality beneath the sham is unavoidable. Unless of course you think the audience and or Jim to be genuinely callous and misogynistic (which you've made clear you do not).

I guess my whole point is that the two bits are functionally almost identical. The only difference I can really see is a different style of delivery and subject matter.

I notice you appear to have dodged the comparisons to his war jokes?

Is there no moral equivalence there? If anything there is far less empathy and personal "truth" being explored. The "little cunt" just dies, Jim never attempts to humanise him or relate the kids experience in an ironic way.

By your logic that routine should be far more offensive surely? (especially when we consider that life and subsequent brutal death in a warzone is quite possibly a more horrible experience than most rapes, especially the kind being discussed here)

bareboards2 said:

@Chairman_woo

"Presumably it's the other thread that's proving challenging, i.e. the masochistic idea of enjoying ones abuse?"

I scanned the comment thread and didn't see anything about this. Are you saying that is what the comedy bit is saying?

I would suggest that you misunderstood his comedic point, like, entirely. Not that I thought it was funny, but I thought he was trying to point up that rape is terrible and that it is "funny" to give different types of rapes grades to bring that point home.

After all, he says repeatedly, I hate rape. I believed him.

I thought it was poorly constructed and not "truthful" like Louis CK gets to the truth of horrible things. But whatever. Not everyone is as brilliant as Louis CK.

However. If you think the joke was some women actually enjoy being digitally raped because they like the idea of being taken against their will in their sexual fantasies, then, to me, you are proving my point that this bit doesn't work.

Of course, it is possible that was indeed the "joke." If it is, then I actively detest this bit and how it actively supports rape culture in our society.

I'm not judging sexual fantasies -- they are what they are. There is, however, a deep difference between sexual fantasies and sexual play and actually, literally, being raped. (I recommend reading Dan Savage's sex advice column. This topic comes up a lot.)

I don't think that is what he meant though. I think the joke is just poorly constructed and he needs to work on it more.

Jim Jefferies on Bill Cosby and Rape Jokes

Chairman_woo says...

*Warning I've only gone and done yet another wall of text again! This may or may not get read by anyone on here (good god I wouldn't blame anyone for skipping it), but at the very least it's formed the backbone to a video script so it's not a complete waste of my time! (he tells himself)*

This is as much @bareboards2 as yourself, but he already made it clear he wasn't willing to engage on the issue, so you're getting it instead MWAHAHAHHAHA! *coughs*

I don't wish this to come across as over condescending (though I'm sure it will none the less as I'm in one of those moods). But pretty much every (successful) comedy premise operates on the same underlying principle of irony. i.e. there is an expectation or understanding, which is deliberately subverted, and what results is comedy.

In this case, amongst other things we have the understood premises that:
A. rape is a bad, often horrific thing.
B. that there is an established social taboo about praising such behaviour.
C. that there is a section of society inherently opposed to making light of things of which they do not approve (or in a way in which they do not approve)
D. most words and phrases have an expected association and meaning.

What Jim Jefferies (an accomplished and well respected comedies amongst his peers) has done here, is take these commonly understood premises and subverted the audiences normal expectations in order to evoke a sense of irony, from which the audience derives humour and amusement.

A simple joke might take a single such premise and perform a single inversion of our expectation. e.g. my dog has no nose, how does he smell?....terrible!

By subverting our assumed meaning (that the missing nose refers to the dogs implied lack of olfactory senses), the joke creates basic irony by substituting this expected meaning for that of the odour of the dog itself.

This is of course a terrible joke, because it is as simple as a joke could be. It has only one layer of irony and lacks any sense of novelty which, might tip such a terrible joke into working for any other than the very young or simple minded.

We could of course attempt to boost this joke by adding more levels of irony contextually. e.g. a very serious or complex comedian Like say Stuart Lee, could perhaps deliver this joke in a routine and get a laugh by being completely incongruous with his style and past material.

And herein we see the building blocks from which any sophisticated professional comedy routine is built. By layering several different strands or ironic subversion, a good comedian can begin to make a routine more complex and often more than just the sum of its parts to boot.

In this case, Jim is taking the four main premises listed above, layering them and trying to find the sweetest spot of subverted expectation for each. (something which usually takes a great deal of skill and experience at this level)

He mentions the fact that his jokes incite outrage in a certain section of society because this helps to strengthen one of the strands of irony with which he is playing. The fact that he also does so in a boastful tone is itself a subversion, it is understood by the audience that he does not/should not be proud of being merely offensive and as such we have yet another strand of irony thrown into the mix.

You know how better music tends to have more and/or more complex musical things happening at once? It is the same with comedy. The more ironic threads a comedian can juggle around coherently, the more sophisticated and adept their routines could be considered to be.

Naturally as with music there's no accounting for taste as you say. Some people simply can't get past a style or associations of a given musician or song (or painting or whatever).

But dammit Jim is really one of the greats right now. Like him or lump him, the dude is pretty (deceptively) masterful at his craft.

There are at least 4-5 major threads of irony built into this bit and countless other smaller ones besides. He dances around and weaves between them like some sort of comedy ballerina. Every beat has been finely tuned over months of gig's (and years of previous material) to strike the strongest harmonies between these strands and probe for the strongest sense of dissonance in the audience. Not to mention, tone of voice, stance, timing etc.

I think Ahmed is basically terrible too, but it is because the jokes lack much semblance of complexity or nuance. Jeff Dunham's material in general feels extremely simple and seems like it uses shock as a mere crutch, rather than something deeper and more intelligent.

Taste is taste, but I feel one can to a reasonable extent criticise things like the films of Michael Bay, or the music of Justin Beiber for being objectively shallow by breaking down their material into its constituent parts (or lack thereof).

Likewise one could take the music of Wagner and while not enjoying the sound of it, still examine the complexity of it's composition and the clear superiority of skill Wagner had over most of this peers.

I guess what all this boils down to is, Jim seems to me to be clearly very very good at what he does (as he ought after all these years). Reducing his act to mere controversy feels a lot like accusing Black Sabbath of just making noise and using satanic imagery to get attention (or insert other less out of date example here).

The jokes were never at the expense of victims, they are at the expense of our expectations. He makes his own true feelings on the matter abundantly clear towards the end of the section.

As as he says himself his job is to say funny things, not to be a social activist.

I take no issue with you not liking it, but I do take issue with the suggestion that it is somehow two dimensional, or for that matter using controversy cheaply.

Offensive initial premises are some of the most ironically rich in comedy. It's like deliberately choosing the brightest paints when trying to create a striking painting. Why would you avoid the strongest materials because some people (not in your audience) find the contrast too striking?

Eh, much love anyway. This was more an exercise in intellectual masturbation than anything else. Not that I didn't mean all of it sincerely.

Jinx said:

When they said he "can't make jokes about rape" what they perhaps meant was "he can't make _jokes_ about rape".

Its dangerous ground. Not saying it shouldn't be walked on, but if you go there with the kind of self-righteous free-speech stuff it always fails to amuse me. I know your joke is offensive. I heard it. When you tell me how offended some ppl were it just sounds like a boast, and don't that sour the whole thing a bit? I mean, maybe I'd feel differently if I thought any controversy was in danger of censoring his material rather than fueling it.

but w/e. No accounting for taste. People still occasionally link me Ahmed the Dead Terrorist, and while that is certainly less risque than the whole rape thing it is a total deal breaker. It's just before "using momentarily to describe something as occurring imminently rather than as something that will be occurring for only a moment" and after "sleeping with my best friend". pet peeves innit.

WeedandWeirdness (Member Profile)

Stupid Human Trick - Gum Control

Security cam captures insane number of crazy events in BC

A song apropos of no particular upcoming election.

ChaosEngine says...

"And I'm starting to feel a lot like Charlton Heston
Stranded on a primate planet
Apes and orangutans that ran it to the ground"

I don't know if they genuinely missed the entire point of Planet Of The Apes or if this is some weird meta-commentary on the kind of people that supported Charlton Heston.

How To Crack An Electronic Safe With A Magnet And A Sock

oritteropo says...

There was an entertaining comment along those lines in a recent Jalopnik article, tell us about the worst car you ever owned, user bandi53 talking about a 1987 Volkswagen Fox that was a bit of a lemon:

[...]
Next was the ignition lock cylinder, which just entirely froze up one morning when I went to start the car. After that was the starter, which left me stranded at the gas station. The day after (Christmas Eve) I was heading back to visit my parents, the alternator light came on... So I figured I’d limp the car home. This would have been a great plan but unfortunately the car caught on fire.

I left it in a mall parking lot with the ownership on the seat, signed, and the keys in the ignition. I hoped I'd never see it again, but driving past two weeks later, it was still there. I came back that night with a trailer and scrapped it myself.

newtboy said:

I take the opposite approach. I drive a 46 year old, rusting, dented, beaten up Bronco. It's doors don't even lock. I've never had trouble with people trying to steal from me, it's fairly obvious I have nothing they want!

Star Trek Beyond - Trailer 1

SDGundamX says...

Uh, isn't the song an homage to the first film when Kirk steals the car and drives it off a cliff (pretty sure this was the song playing in the background)?

Look, this is the 3rd movie in the rebooted franchise. Do people really not get the idea of a "reboot"? They're not re-making Star Trek, they're taking it in an entirely different direction. The first one clearly showed they wanted to go in the blockbuster action film direction and the second one re-affirmed that. So, it completely baffles me as to why anyone at this point would still think the rebooted franchise is going to be anything like the original Star Trek movies (let alone the TV series, which had far more time to build the characters and establish the universe than the movies do).

Now, as to the particulars of this trailer... they're going to blow up the Enterprise, again?!? We haven't "been there, done that" enough yet? And so much for their 5-year mission--looks like that is going to get cut a little short.

Still the idea of the main cast members getting stranded on a hostile planet is pretty good for allowing some cool between-character interaction and does in fact harken back to all of the TV series versions (where it seemed to happen on a fairly regular basis).

Will wait and see. Probably will be a good action popcorn flick (which is clearly what they want the series to be).

Making a Sling-Primitive Technology

Stormsinger says...

I'm thinking that if one were stranded in such a forest, your time and energy might be better spent in hiking out, or maybe in finding and cultivating edible plants. Given his hit ratio, he'd be going hungry most days.

How to DMT

shagen454 says...

I'm sure there are people out there that have come up with software/technology from the influence of DMT, they just haven't come forth. I'd say that it has recognizably influenced ideas & thought - especially in the area of frequencies, energy, reality is a hologram sort of shit like that because the DMT experience is the frequency, mandala portal experience, lol! It's certainly influenced great art, look at Alex Grey. I've learned a lot of things that seem to not apply to this reality and the last time I took it, the only thing I learned was "GOOGLE", lol.

LSD on the otherhand has definitely influenced technology and science. My favorite LSD thought experiment become reality was Francis Crick's discovery of the DNA strand while on it.

"I'm still waiting for the insightful invention someone comes up with after one of these amazing 'conversations' with non-human beings. If this drug really did what those into it claim, you would expect most users to be incredible 'outside the box' inventors advancing science in ways normal people would never consider...but I have not heard of even a single instance of that kind of useful insight coming from DMT."

newtboy said:

The best way to reduce risk from taking, or getting caught with DMT is to not do it.

The Martian | Official Trailer #1

ChaosEngine says...

upvote for "I'm gonna have to science the shit outta this".

Hopefully, this will be Ridleys sci-fi redemption after Prometheus.

Also, Matt Damon's gonna start to feel like directors really want to strand him on another planet.



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