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Already in 385 C.E. the first Christians, the Spanish Priscillianus and six followers, were beheaded for heresy in Trier/Germany
Manichaean heresy: a crypto-Christian sect decent enough to practice birth control (and thus not as irresponsible as faithful Catholics) was exterminated in huge campaigns all over the Roman empire between 372 C.E. and 444 C.E. Numerous thousands of victims.
Albigensians: the first Crusade intended to slay other Christians.
The Albigensians (cathars = Christians allegedly that have all rarely sucked) viewed themselves as good Christians, but would not accept roman Catholic rule, and taxes, and prohibition of birth control.
Begin of violence: on command of pope Innocent III (greatest single pre-nazi mass murderer) in 1209. Bezirs (today France) 7/22/1209 destroyed, all the inhabitants were slaughtered. Victims (including Catholics refusing to turn over their heretic neighbours and friends) 20,000-70,000.
* Carcassonne 8/15/1209, thousands slain. Other cities followed.
* subsequent 20 years of war until nearly all Cathars (probably half the population of the Languedoc, today southern France) were exterminated.
* After the war ended (1229) the Inquisition was founded 1232 to search and destroy surviving/hiding heretics. Last Cathars burned at the stake 1324.
* Estimated one million victims (cathar heresy alone),
* Other heresies: Waldensians, Paulikians, Runcarians, Josephites, and many others. Most of these sects exterminated, (I believe some Waldensians live today, yet they had to endure 600 years of persecution) I estimate at least hundred thousand victims (including the Spanish inquisition but excluding victims in the New World).
* Spanish Inquisitor Torquemada alone allegedly responsible for 10,220 burnings.
* John Huss, a critic of papal infallibility and indulgences, was burned at the stake in 1415.
* University professor B.Hubmaier burned at the stake 1538 in Vienna.
* Giordano Bruno, Dominican monk, after having been incarcerated for seven years, was burned at the stake for heresy on the Campo dei Fiori (Rome) on 2/17/1600.

# 5th century: Crusades against Hussites, thousands slain.
# 1538 pope Paul III declared Crusade against apostate England and all English as slaves of Church (fortunately had not power to go into action).
# 1568 Spanish Inquisition Tribunal ordered extermination of 3 million rebels in (then Spanish) Netherlands. Thousands were actually slain.
# 1572 In France about 20,000 Huguenots were killed on command of pope Pius V. Until 17th century 200,000 flee.
# 17th century: Catholics slay Gaspard de Coligny, a Protestant leader. After murdering him, the Catholic mob mutilated his body, "cutting off his head, his hands, and his genitals... and then dumped him into the river [...but] then, deciding that it was not worthy of being food for the fish, they hauled it out again [... and] dragged what was left ... to the gallows of Montfaulcon, 'to be meat and carrion for maggots and crows'."
# 17th century: Catholics sack the city of Magdeburg/Germany: roughly 30,000 Protestants were slain. "In a single church fifty women were found beheaded," reported poet Friedrich Schiller, "and infants still sucking the breasts of their lifeless mothers."
# 17th century 30 years' war (Catholic vs. Protestant): at least 40% of population decimated, mostly in Germany.