In the summer of 1741 Handel, at the peak of his musical prowess but depressed and in debt, began setting Charles Jennens' Biblical libretto to music at his usual breakneck speed. In just 24 days, Messiah was complete (August 22 - September 14). Like many of Handel's compositions, it borrows liberally from earlier works, both his own and those of others.

It was premiered during the following season, in the spring of 1742, as part of a series of charity concerts in Neal's Music Hall on Fishamble Street near Dublin's Temple Bar district. Right up to the day of the premiere, Messiah was troubled by production difficulties and last-minute rearrangements of the score, and the Dean of St. Patrick's Cathedral, Jonathan Swift, placed some pressure on the premiere and had it cancelled entirely for a period. He demanded that it be retitled A Sacred Oratorio and that revenue from the concert be promised to local hospitals for the mentally ill. The premiere happened on 13 April at the Music Hall in Dublin, and Handel led the performance from the harpsichord with Matthew Dubourg conducting the orchestra.

Women were asked not to wear hooped dresses and men not to wear swords so more people could fit in the theatre!