So if you synthesize your own through exposure to sunlight, you’re good? Or at least better off?
Is it possible that it’s not the delivery method, but the systems that use vitamin D being healthy beforehand vs being supplemented after the fact? Maybe it takes a while to get those systems healthy, and supplements don’t help with that.

Edit: Maybe, since the same receptors are used to metabolize vitamin D as to infect a cell with covid, those receptors being “full” might be what’s stopping infections, and dosing with vitamin D after infection doesn’t magically replace the Covid with vitamin D? Not really about vitamin D or why you need it, just about the mechanism the body uses to use the vitamin D? Biology is intricate, and why things work and how is not always clean and simple.

Melatonin? Then why aren’t people with more melatonin, people of color, nearly immune? Why are island nations like the Virgin Islands still having outbreaks today? Why were Southern states hit just as hard or harder than northern states? Many questions here.

His explanation seems to confirm this. If your cells produce vitamin D efficiently, they are less prone to infections, if you artificially add artificial vitamin D, it helps with the cellular functions, but the processes that should be producing it are still suppressed, possibly more because your body isn’t triggering them due to low vitamin D levels. It’s less about overall vitamin D levels than about having healthy systems that properly produce and utilize it….at least that’s my takeaway.

It’s not just about sunlight..it’s about diet, overall health, sleep, etc. biology is complex, and we always want a simple solution. There isn’t one most of the time, and our attempts to simplify only make things worse. Eat well, sleep well, get some sun, get some exercise, and you’ll be as safe as you can be naturally….then try supplements in addition, not instead.

I get plenty of sun, and my windows are from the 50’s. It definitely makes me feel better to get sun, but there’s a limit. Don’t just go sunbathe in Arizona, use your brain.

Capsaicin ---from no less than Cook's Illustrated

"Milk had only a slight impact. What worked on both the skin and the mouth? Hydrogen peroxide.

It turns out that peroxide reacts with capsaicin molecules, changing their structure and rendering them incapable of bonding with our receptors. Peroxide works even better in the presence of a base like baking soda:

We found that a solution of 1/8 teaspoon of baking soda, 1 tablespoon of water, and 1 tablespoon of hydrogen peroxide could be used to wash the affected area or as a mouthwash (swish vigorously for 30 seconds) to tone down a chile’s stinging burn to a mild warmth. (Toothpaste containing peroxide and baking soda is a somewhat less effective remedy.) Always keep peroxide, baking soda, and toothpaste away from your eyes."

Essentially there is no such thing as white light or indeed pink light. White light is when all your color receptors are saturated, what you think of as pink is when blue and red light is combined, and the possible wavelength combinations in both cases are sadly endless and impossible to represent fully in a simple table or graph.

Pink is a relatively easy color for monitors because, unlike for example yellow, pink is always a combination of blue and red light, while real life yellow is represented by a combination of blue and green light on your monitor and blue and green receptors in your eye. So yellow exists but we only ever see its representation as a mix of green and blue, while pink is a virtual colour all round :-)

Yes I suspect fluorescense is at play in this case somehow.

With RGB and CMYk the key word is representatiom. There are real life impressions of colours, and then there is the wish for standardisation and representation, but the eye is a very imperfect tool and representation is approximate. Real life paintings are awesome and you dont even come close watching photographs or computer monitors or prints in books.

I can't start the day without adenosine receptor antagonists

In these videos they always say "are you okay?" before the pain receptors have even had a chance to respond.

I read an interesting article on the BBC's web site on exactly this question - http://www.bbc.com/earth/story/20160404-why-some-animals-have-venoms-so-lethal-they-cannot-use-them

It makes some of the same points as this video, but also has an additional one in regards to why some animals are so toxic to humans: Bad luck! We aren't their targetted prey, so it's pretty much irrelevent to them whether their sting can kill one or 1,000 humans.

Bad luck comes into it as well. A bite from a Sydney funnel-web spider is extremely dangerous for humans, whereas rodents are relatively unaffected by their venom. Since these spiders evolved to eat neither rodents nor humans, this can be seen as nothing more than an unfortunate alignment of the spider's neurotoxin with a receptor on some of our cells.

$15,000 dildo sounds totally worth it. https://www.lelo.com/inez

Thor Buckswallow writes:
"This is the kind of toy that only comes around once in a lifetime. When you first insert this gorgeous pleasure rod into your hoo hah, your toes will curl while your left arm goes numb as receptors fly across your body delivering messages that could end world hunger. The first time I unboxed this hedonist pole and rammed it like a battering ram into the door of a third-world immigrant living in Germany into my vaginal cavity, I screamed so loud that my neighbors (who live 3 miles away on their own estate) called the police. I had to pay off the local police chief so he would bury the incident. Not a negative, though, since paying the local authorities off so they wouldn't interfere with the weekend torture rituals was on my to-do list anyways! LOL! Great product, would recommend."


Although I 'll be spending my hard earned money on this special treat.

"Earl", Quite simply the most distinguished gentleman’s plug in the world, is the finest butt plug in the land and for $2590 a bargain. https://www.lelo.com/earl

Ummm....yeah, what s/he said. They all seem like late-adopters to me.

And frankly, I have never understood the "burn on the way out" myth/phenomenon. It must be psychological, or my taste receptors suck all the capsaicin away at first contact.

Personally, I just get the hick-ups when I approach my limit.
BTW, my preference is for the naga bhut jolokia. Chiles for Life!

Wow, powerful video. I think this is why certain psychedelics, can (can) help people with addictions or even people with simple obsessions (porno, video games, etc). They have the potential to temporarily exit the cage for self reflection or experience outside of it. Some of the more powerful ones (iboga, ayahuasca) really physiologically reset the afflicted receptor sites - and much much more.

I agree whole-heartily that the way that the US handles drug addiction, mental illness & criminality are completely out of whack. Implying that the direct parallels between those subjects are ignorance (or taboo), incarceration & the lack of clear, precise scientifically proven reformation.

That sounds a whole lot like some kind of absurd "Reefer Madness" kind of "thinking."

On what are you basing that "feeling?" Leaving aside that serotonin is involved with mood (and not meaning or motivation) and that LSD's binding to the receptor sites increases not decreases the amount of serotonin available in the synaptic cleft (performing the same effect as any other SSRI like Zoloft, Paxil, or Prozac), there is actually no reason why any of the hundreds of successful professionals that I know who have taken LSD multiple times would express such a feeling on the basis of taking LSD.

If anything, your comment reveals a fear of your own mind and, having read your comments, I can't say I blame you.

Found the video more enjoyable once i read this:

Both green olives (Olea europaea) and Pimentos (Capsicum annuum) contain isoprenoids that are structurally similar to the methylcyclopentane monoterpene nepetalactone, which is responsible for binding to receptors in you cat's vomeronasal organ and consequently the mind-altering effect your cat experiences.
These compounds are not unusual, although thie configuration varies widely between plant species.
These compounds resemble pheromones, and as such some of them function as a natural mock-pheromone pest repellents for the plant, which is likely how such high levels of these constituents within a plants' essential oils evolved.
The vomeronasal organ is what your cat (and most other animals with the exception of humans, although there is a small indented area and partial nerve channel where it would be, left over from our evolution) uses to sense pheromones, and is where the nepetalactone in catnip stimulates pheromone receptors resulting in space-kitty.

TL;DR - it is likely that either the green olives or pimentos have a chemical in their essential oil that is similar enough to the active chemical in catnip to have a similar effect on the same receptors in the part of kitty's nose that are responsible for catnip getting her high.
(from Yahoo Answers via reddit)

TONS of things cure cancer. All day, every day. Doctors have no clue what cancer is. All they can do is cut, burn, or poison and cross their fingers.

I didn't say Cannabis was THE cure. It is A cure used by thousands with amazing efficacy. Everyone is different.

Here's 60+ studies for your perusal if you insist on the superiority of western scientific research:

"Cannabis, and the cannabinoid compounds found within it, has been shown through a large cannabisplantamount of scientific, peer-reviewed research to be effective at treating a wide variety of cancers, ranging from brain cancer to colon cancer. Below is a list of over 60 studies that demonstrate the vast anti-cancer properties of cannabis.
Studies showing cannabis may combat brain cancer:
Cannabidiol (CBD) inhibits the proliferation and invasion in U87-MG and T98G glioma cells. Study published in the Public Library of Science journal in October 2013.
Tetrahydrocannabinol (THC) can kill cancer cells by causing them to self-digest. Study published in the Journal of Clinical Investigation in September 2013.
CBD is a novel therapeutic target against glioblastoma. Study published in Cancer Research in March 2013.
Local delivery of cannabinoid-filled microparticles inhibits tumor growth in a model of glioblastoma multiforme. Study published in Public Library of Science in January 2013.
Cannabinoid action inhibits the growth of malignant human glioma U87MG cells. Study published in Oncology Reports in July 2012.
Cannabidiol enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival. Study published in the Molecular Cancer Therapeutics journal in January 2010.
Cannabinoid action induces autophagy-mediated cell death in human glioma cells. Study published in The Journal of Clinical Investigation in May 2009.
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Study published in Cancer Research in March 2008.
Cannabinoids and gliomas. Study published in Molecular Neurobiology in June 2007.
Cannabinoids inhibit gliomagenesis. Study published in the Journal of Biological Chemistry in March 2007.
A pilot clinical study of THC in patients with recurrent glioblastoma multiforme. The results were published in the British Journal of Cancer in June 2006.
Cannabidiol inhibits human glioma cell migration through an independent cannabinoid receptor mechanism. Study published in the British Journal of Pharmacology in April 2005.
Cannabinoids inhibit the vascular endothelial growth factor pathway (VEGF) in gliomas. Study published in the Journal of Cancer Research in August 2004.
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. Study published in the Journal of Pharmacology in November 2003.
Inhibition of glioma growth in vivo by selective activation of the CB2 cannabinoid receptor. Study published in the Journal of Cancer Research in August 2001.
Studies showing cannabis may combat colorectal cancer:
Cannabigerol (CBG) can inhibit colon cancer cells. Study published in the Oxford journal Carcinogenesis in October 2014.
Inhibition of colon carcinogenesis by a standardised Cannabis Sativa extract with high content of CBD. Study published in Phytomedecine in December 2013.
Chemopreventive effect of the non-psychotropic phytocannabinoid CBD on colon cancer. Study published in the Journal of Molecular Medecine in August 2012.
Cannabinoids against intestinal inflammation and cancer. Study published in Pharmacology Research in August 2009.
Action of cannabinoid receptors on colorectal tumor growth. Study published by the Cancer Center of the University of Texas in July 2008.
Studies showing cannabis may combat blood cancer:
The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. Study published in the International Journal of Cancer in December 2013.
Enhancing the activity of CBD and other cannabinoids against leukaemia. Study published in Anticancer Research in October 2013.
Cannabis extract treatment for terminal acute lymphoblastic leukemia of Philadelphia chromosome (Ph1). Study published in Case Reports in Oncology in September 2013.
Expression of type 1 and type 2 cannabinoid receptors in lymphoma. Study published in the International Journal of Cancer in June 2008.
Cannabinoid action in mantle cell lymphoma. Study published in Molecular Pharmacology in November 2006.
THC-induced apoptosis in Jurkat leukemia. Study published in Molecular Cancer Research in August 2006.
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Study published in Blood American Society of Hemmatology in July 2002.
Studies showing cannabis can combat lung cancer:
Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of Icam-1. Study published in Biochemical Pharmacology in July 2014.
Cannabinoids inhibit angiogenic capacities of endothelial cells via release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells. Study published in Biochemical Pharmacology in June 2014.
COX-2 and PPAR-γ confer CBD-induced apoptosis of human lung cancer cells. Study published in Molecular Cancer Therapeutics in January 2013.
CBD inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. Study published in the Journal of the Federation of American Societies for Experimental Biology in April 2012.
Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non–small cell lung cancer growth and metastasis. Study published in Cancer Prevention Research in January 2011.
THC inhibits epithelial growth factor-induced (EGF) lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Study published in the journal Oncogene in July 2007.
Studies showing cannabis may combat stomach cancer:
Cannabinoid receptor agonist as an alternative drug in 5-Fluorouracil-resistant gastric cancer cells. Study published in Anticancer Research in June 2013.
Antiproliferative mechanism of a cannabinoid agonist by cell cycle arrest in human gastric cancer cells. Study published in the Journal of Cellular Biochemistry in March 2011.
Studies showing cannabis may combat prostrate cancer:
Cannabinoids can treat prostate cancer. Study published by the National Institute of Health in October 2013.
Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms. Study published in the British Journal of Pharmacology in December 2012.
The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications. Study published in the Indian Journal of Urology in January 2012.
Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent. Study published in Anticancer Research in November 2011.
Studies showing cannabis may combat liver cancer:
Involvement of PPARγ in the antitumoral action of cannabinoids on hepatocellular carcinoma (CHC). Study published in Cell Death and Disease in May 2013.
Evaluation of anti-invasion effect of cannabinoids on human hepatocarcinoma cells. Study published on the site Informa Healthcare in February 2013.
Antitumoral action of cannabinoids on hepatocellular carcinoma. Study published in Cell Death and Differentiation in April 2011.
Studies showing cannabis may combat pancreatic cancer:
Cannabinoids inhibit energetic metabolism and induce autophagy in pancreatic cancer cells. Study published in Cell Death and Disease in June 2013.
Cannabinoids Induce apoptosis of pancreatic tumor cells. Study published in Cancer Research in July 2006.
Studies showing cannabis may combat skin cancer:
Cannabinoid receptor activiation can combat skin cancer. Study published by the National Institute of Health in October 2013.
Cannabinoids were found to reduce skin cancer by 90% in just 2 weeks. Study published in the Journal of Pharmacy and Pharmacology in July 2013.
Cannabinoid receptors as novel targets for the treatment of melanoma. Study published in the Journal of the Federation of American Societies for Experimental Biology in December 2006.
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. Study published in the Journal of Clinical Investigation, in January 2003.
Studies showing cannabis may combat other types of cancer:
Bladder: Marijuana reduces the risk of bladder cancer. Study published in the Medscape site in May 2013.
Kaposi sarcoma: Cannabidiol inhibits growth and induces programmed cell death in Kaposi sarcoma–associated herpesvirus-infected endothelium. Study published in the journal Genes & Cancer in July 2012.
Nose, mouth, throat, ear: Cannabinoids like THC inhibit cellular respiration of human oral cancer cells. Study by the Department of Pediatrics at the State University of New York, published in June 2010.
Bile duct: The dual effects of THC on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration. Study published in Cancer Investigation in May 2010.
Ovaries: Cannabinoid receptors as a target for therapy of ovarian cancer. Study published on the American Association for Cancer Research website in 2006.
Preparation and characterisation of biodegradable microparticles filled with THC and their antitumor efficacy on cancer cell lines. Study published in the Journal of Drug Targeting in September 2013.
CBD Cannabidiol as a potential anticancer drug. Study published in the British Journal of Pharmacology in February 2013.
Cannabinoids as anticancer modulators. Study published in the Progress in Lipid Research journal in January 2013.
CBD inhibits angiogenesis by multiple mechanisms. Study published in the British Journal of Pharmacology in November 2012.
Towards the use of cannabinoids as antitumour agents. Study published in Nature in June 2012.
Cannabinoid-associated cell death mechanisms in tumor models. Study published in the International Journal of Oncology in May 2012.
Cannabinoids, endocannabinoids and cancer. Study published in Cancer Metastasis Reviews in December 2011.
The endocannabinoid system and cancer: therapeutic implication. Study published in the British Journal of Pharmacology in July 2011.
This list was compiled in part by Alchimiaweb.com.
– TheJointBlog"

I remember this guy.

Kicked out of Tulane university for one of the worst research papers in its history. This is the guy that doesn't even believe in how our eyes function:

"There is in fact no evidence at all that having this layer of nerve fibres (which are largely transparent) in front of the receptors significantly blocks, distorts or diffracts the incoming light in any way."

Total ripoff artist.

If you believe he was ever an Atheist, then I have a secret to tell you.

I am the Batman.

'Mandies' (Mandrax were the Mexican-copy equiv of the 714 back in the early 80's) act on receptors akin to any barbituate or benzo-type drugs with an added kinna psychoactive kick-The one time I took a half a one I lost time, passed-out, had about 2 hours of chill-time groovy before I got really rubbery and stupid. Next day, was still fucking high and had forgotten most of the night before.

Nasty shit, they work the central nervous system hard-over. Would recommend one after some debilitating injuries that kept you awake from pain. Certain people can party on em, but I'd stay the fuck away from those folks.

Well I disagree, wouldn't exactly call it 'reasonable'......lantern53 is coming from a position of familiarity with the fraternity though he's quite honest in his motivations for his addictive love for his chosen 'profession', as it provides that calming "rush" of the constant stimulus of adrenal secretions to feed those over-ramped receptors that his habit constantly demands.

He's career, so his attitude ain't gonna change much folks...

He's admitted that he'll 'play-ball' in a courtroom situation to save his job and pension, and plays the frat card again when someone suggests that 'all cops are criminals', which they obviously are (especially in the United States) to any reasonable individual, oh and, when faced with being judged by a reasonable public standard by the people he's allegedly pledged to protect and serve, he'll 'judge' them by a similar, opposite standard, when he sees himself threatened with a realization that they could in fact, be correct in their judgements.

Typical. Programmed, frightened and confused, American, cop.

Yeah man, you night wanna check your shit and decide whether-or-not you're one of the bad ones?? Because you sound like the worst example of so-called 'law-enforcement' to this sinner.

If it squeals like a pig, smells like a pig.....

(Oh, for all you youngsters whose hippie-parents now work for the machine, the term "pig" was used as a derogatory and appropriate euphemism for the police back in the 60s when that dick-less generation failed to shut-down the runaway freight train of human subjugation in the United States.)