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Professor Brian Harvey On Why Not To Cheat

newtboy says...

I thought you were saying everyone can benefit from chemical compounds that react in their body to produce certain effects.
That I agree with.

That everyone should use recreational (I'm assuming including unregulated, blackmarket, psychoactive) drugs I strongly disagree with.
Many people are not mentally equipped to have a single light beer, one of the least potent recreational drugs while some few can successfully smoke crack in moderation. Many don't have the experience to avoid fake, adulterated, or deadly drugs. Some have physical limitations that could make a joint deadly.

Remember, especially with humans, there are always exceptions to any rule.

kir_mokum said:

i am talking about recreational drugs.

and what is it you think i'm saying?

What We Know about Pot in 2017

Sniper007 says...

"How you read this report is going to be clouded by how you feel about pot in general." Bingo.

No no new science here, though. No new studies. Just re-re-reviewing existing literature.

"We know almost nothing about the medicinal effects of smoked marijuana."

If that's true... then how much do "we" know about the effects of raw cannabis, complete with it's non-psychoactive tetrahydrocannabinolic acid? The large scale, peer reviewed method works far, far to slowly to be of any real use. It is too dependent upon those with enough financial funding to be considered an authority. If "we" finally perform the "right" study on cannabis, will that magically undo nearly 100 years of unjustified criminalization, untold millions of needless deaths, and pain and suffering?

Dr. Gupta thinks denying Medicinal Marijuana is Immoral

poolcleaner says...

My migraines aren't in remission but I don't suffer nearly as long as I used to since using light psychoactive CBD/THC. Duration of intense pain, loss of vision, loss of feeling in limbs, nausea, vomiting, and the rare seizure has been reduced from 6-12 hours every 2-4 weeks to maybe 2 hours every couple months, sometimes only with nausea, loss of vision, and minor or no pain.

However, the loss of vision, or what my doctors have referred to as visual "premonitions" are still a major pain that I'm not certain will ever go away. Luckily I don't get very many migraines any more. However, if I do get a migraine I still cannot drive or do anything that requires sight. Although I can technically see, it's severely impaired.

The absence or dulling of the pain during a migraine is the greatest thing that has ever happened to me medically. I had a migraine 2 days ago while I was jogging at the park, ran to my car so I could quickly get home before my vision was fucked, and then placed a soluble CBD + THC tablet (Trokie) up into the corner of my mouth where it was slowly absorbed into the facial branches of my carotid artery. After my vision cleared up, I had no headache.

Keep in mind I also take a pure CBD tablet every couple days, so it's not just the one tablet during episodes.

The Synthetic Marijuana Steampunk Rock Opera

AeroMechanical says...

My one experience with synthetic ganja, which was apparently a pretty good one some years back before it was banned, ended with me saying "jesus fucking christ, why would anybody use this stuff?" It was psychoactive, so I guess there's that, but it was pretty much just the bad THC/halluciongenic side effects without the good effects.

I'm sure it probably could be done right, but you know, there's always the real thing if you want to use drugs.

How to DMT

newtboy says...

Yes, my teenage years were irresponsible, and a main reason I often chime in to suggest at least having serious knowledge about what you're doing and safety precautions before going this route.

Yes, because it is different for different people, and even different for the same person dependent on their mindset when they take it, it's impossible to be totally 'safe' when taking it, even with full knowledge. You can't know for sure how it will react with you, or how you'll react to it until it's too late.

Making your own, if you're a decent chemist, at least gives you a good idea of WHAT you're taking, but without spectral analysis, you can't know the strength of the psychoactives for certain. Also, that probably leaves you open to more legal trouble for manufacturing a schedule 1 narcotic...more reason to not go in public and take it and get caught.

The fear is that, when someone is having a bad trip, they aren't likely to think straight enough to take something to counter act the effects...even if they're smart enough to have that handy. Unfortunately, a clinical setting is probably also not conducive to a great experience, so 'under a doctor's supervision' isn't really totally helpful or practical.

The quantum mechanics part can be understood, he seemed to have just miss-stated/miss-understood what the experiment was about in his wish to find some science that explains his experience, which may not be understandable.

newtboy (Member Profile)

enoch says...

i am not surprised we pretty much agree.

you should always be careful with any substance and to be informed is the first step.
was i careful at 15 with double barrel purple mescaline?---->nope.i was 15.

but i think the argument is getting caught up in distinctions,which is common.
when i speak of psychedelics,i am talking about:LSD,shrooms,mescaline.
and while exstacy is considered a psychedelic,and it IS a psychedelic (and awesome btw),i also consider that drug to be more a "club" drug,a designer drug,and yes...it can be fatal because often it is NOT mdma/mda you're are taking but a cocktail of bullshit with a few experimental chemistry molecules thrown in...so your cautionary tale is not exactly unfounded..but i have never seen shagen even suggest mdma/mda but almost exclusively:DMT.

now,i am fairly cautious in suggesting DMT to the uninitiated due to the fact of its potency (even in small amounts).there is no small build up with DMT,it goes from first gear to 15th in 2.2 seconds,and for a newcomer that can easily overwhelm and frighten.

for psychedelics to produce a positive and healthy response there first has to be interest in trying psychedelics out.the worst thing you could EVER do is "hey man,i just filled your beer with shroom tea" (you would notice though,that shit tastes like concentrated ass).

the person should also be in the right frame of mind and be in a place and with people they feel comfortable with and trust (very important the first time).knowing the dosage is important but not as important as you would think,as long as you take things slow and with patient care..things will sort out nicely.

as for death and permanent brain damage.i am not familiar with any cases except for the movie they showed us in the 7th grade with helen hunt thinking she could fly,because she took acid.i know psychedelics can affect a personality permanently (usually for the better) but nothing life threatening.i know too high a dosage on a novice mind can cause a "bad" trip and leave an unpleasant memory of the experience.there have been cases of latent mental illnesses manifesting due to the psychedelics,but it didnt CAUSE the mental illness.

from my own personal experience and what i have read,psychedelics are pretty safe.they are not a toy.they are an extremely powerful psychoactive compound that should always be treated with respect and to ignore that can have consequences.

but i dont think death and permanent brain damage are on that list.

unless you decided to do something stupid while tripping,but that is evolution,not psychedelics.

i could always come to california and we could drink shroom kool-aid.hang out on the moutain-side and watch the sunset and by the time we are watching the sunrise we will have become blood brothers and watched the universe expand in glorious birth pangs and then collapse upon itself in its death throes.talked to stars and danced with super novas.find ourselves in a meadow,thinking we walked half the state only to realize we are a 1/4 mile from your back porch.

i promise good times my friend.good times indeed.

the man who gets 100 orgasms a day

WaterDweller says...

I wonder if he's tried medications to dampen his arousal. There are several psychoactive drugs that have reduced desire, impotence and inability to orgasm as side effects. For normal people, that tends to be distressing, but in his case, it might be worth a try. Though there are plenty of other, less than desirable side effects to deal with as well.

Mother of Four Cures PTSD With MDMA

chingalera says...

....and to interject here for clarity and general edification and enlightenment, that the OVERUSE of the words 'just', 'actually', and my personally-peevish pet-polemic, 'CLEEEARLY' -(God, I fucking detest the abuse of this particular word esp. when used to begin a sentence/statement with a view to arguing some complete and utter bullshit with very telling emotionally-fueled, idiotic prattle), should sound as a warning to all that what you are about to read is a load of self-delusional horseshit.

Please smarty-pants, argue and defend MORE bullshit and reveal to all your lifetime extant of dysfunctional programming with these flaccid idioms designed to abuse logic, reason, and common-sense and experience the warm sensation of having your fuck-shit-stack of words inserted gently into and up your own ass.

Ahem. That said, any psychoactive drugs (some are better than others) combined with proper navigation through a qualified proctor, set, and setting can be utilized to re-write or substantially inhibit or reverse the ill-effects of traumatic imprinting and programming.

The Wolf of Wall Street -- Quaaludes scene

chingalera says...

'Mandies' (Mandrax were the Mexican-copy equiv of the 714 back in the early 80's) act on receptors akin to any barbituate or benzo-type drugs with an added kinna psychoactive kick-The one time I took a half a one I lost time, passed-out, had about 2 hours of chill-time groovy before I got really rubbery and stupid. Next day, was still fucking high and had forgotten most of the night before.

Nasty shit, they work the central nervous system hard-over. Would recommend one after some debilitating injuries that kept you awake from pain. Certain people can party on em, but I'd stay the fuck away from those folks.

eric3579 said:

As someone who has never done Quaaludes. Is this a realistic depiction of what its like on ludes? Clear thinking of mind but complete loss of control of your body? If so, I just don't get what the appeal could possibly be. Nothing about this scene looks fun and last i checked doing drugs for kicks is suppose to be hella fun.

Short story about the astronaut, Ronald McNair

chingalera says...

What the fuck is a troll and MY GOD!!? Aren't we the smart-ass.

Fitting too, that my last power-point earned trough resurrecting the dead vids was given to Januari, my comment applauded by some of the more self-aware individuals on the site, and you come in to do what you do best, be that actual troll that you are. I would like to discuss it with you at arm's length over broken glass but, you have chosen to ignore yourself so, round and round and motherfucking round your own, pathetic, dysfunction.

Thank you with a personal hard-on to see me burn because of your inability to process constructive criticism. We ALLLL love your contributions of video content and selective bullying as well, newtboy. You may well benefit from licking the glands of a few psychoactive frogs, maybe pop a few mushrooms?? Know thyself, motherfuckers.

He said jokingly...give me a fucking break!!? Hiding behind an invocation to avoid prosecution-Are you not, in doing so repeatedly, implicating yourself??

Fuck him once, shame on you....

newtboy said:

^ More Trolling

Stuff They Don't Want You to Know - DMT

chingalera says...

...roughly as can be kirmokum, given the language with which to describe the experience filtered through the individual perceptive apparatus. I like to think that the architect left these chemical triggers in the species with a view towards our acclimation to higher brain function and adaptation to chaotic internal and external stimuli, as well as a catalyst for the species continuing evolution.
After having experienced DMT as well as several other psychoactive substances, the very idea that a government, religion, or any such construct of human societies would seek to imprison someone for the personal use of the same should be an indicator to anyone who values free will and basic human rights as to the nefarious ends of that construct.
First, eliminate the constructs....then we find the contractors and hunt THEM down!

Dr Sanjay Gupta's CNN Special "WEED"

vaire2ube says...

CBD possesses sedative properties (Carlini and Cunha, 1981), and a clinical
trial showed that it reduces the anxiety and other unpleasant psychological
side effects provoked by pure THC (Zuardi et al. 1982). CBD modulates the
pharmacokinetics of THC by three mechanisms: (1) it has a slight affinity for
cannabinoid receptors (Ki at CB1 = 4350 nM, compared to THC = 41 nM,
Showalter et al. 1996), and it signals receptors as an antagonist or reverse agonist
(Petitet et al. 1998), (2) CBD may modulate signal transduction by perturbing
the fluidity of neuronal membranes, or by remodeling G-proteins that
carry intracellular signals downstream from cannabinoid receptors, and (3)CBD
is a potent inhibitor of cytochrome P450 3A11 metabolism, thus it blocks the
hydroxylation of THC to its 11-hydroxy metabolite (Bornheim et al. 1995).
The 11-hydroxy metabolite is four times more psychoactive than unmetabolized
THC (Browne and Weissman 1981), and four times more immunosuppressive
(Klein et al. 1987).
CBD provides antipsychotic benefits (Zuardi et al. 1995). It increases dopamine
activity, serves as a serotonin uptake inhibitor, and enhances norepinephrine
activity (Banerjee et al. 1975; Poddar and Dewey 1980). CBD protects
neurons from glutamate toxicity and serves as an antioxidant, more potently
than ascorbate and α-tocopherol (Hampson et al. 1998). Auspiciously, CBD
does not decrease acetylcholine (ACh) activity in the brain (Domino 1976;
Cheney et al. 1981). THC, in contrast, reduces hippocampal ACh release in
rats (Carta et al. 1998), and this correlates with loss of short-term memory consolidation.
In the hippocampus THC also inhibits N-methyl-D-aspartate (NMDA)
receptor activity (Misner and Sullivan 1999; Shen and Thayer 1999), and
NMDA synaptic transmission is crucial for memory consolidation (Shimizu et
al. 2000). CBD, unlike THC, does not dampen the firing of hippocampal cells
(Heyser et al. 1993) and does not disrupt learning (Brodkin and Moerschbaecher
1997).
Consroe (1998) presented an excellent review of CBD in neurological disorders.
In some studies, it ameliorates symptoms of Huntington’s disease, such
as dystonia and dyskinesia. CBD mitigates other dystonic conditions, such as
torticollis, in rat studies and uncontrolled human studies. CBD functions as an
anticonvulsant in rats, on a par with phenytoin (Dilantin, a standard antiepileptic
drug).
CBD demonstrated a synergistic benefit in the reduction of intestinal motility
in mice produced by THC (Anderson, Jackson, and Chesher 1974). This
may be an important component of observed benefits of cannabis in inflammatory
bowel diseases.

--"Cannabis and Cannabis Extracts:
Greater Than the Sum of Their Parts?
John M. McPartland
Ethan B. Russo"

15 Things Every Coffee Drinker Should Know

AeroMechanical says...

I'm not seeing the logic to the "works much like heroin" thing. If all that implies is that both are psychoactive drugs, okay, but otherwise they are about as different from each other as can be. Cocaine might have been a better example.

THE UNBELIEVERS - Richard Dawkins & Lawrence Krauss

chingalera says...

^^ Thanks for sharing your Dimty reflections, nothing quite like standing in that temple-Did you ever talk to the entities that reside in that space? There's an intelligence there that's not an wholly subjective, associative conjuring of the mind-I know it's a consciousness outside of oneself, maybe a higher self-It's sentient and outside of the realm of any other psychoactive subs I have ever taken.

My first DMT trip I flew through a huge, smiley-face grid (I think I had just seen the Watchmen) before I reached something I did not recognize from all my flight time till then.......Great stuff...Life-affirming and purgative and, you can do it on your LUNCH HOUR!!

The Science of Lucid Dreaming



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