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Herbs And Empires: A Brief History Of Malaria Drugs
Interesting. I've got a semi-relevant story, but I get long winded so feel free to skip to the next comments if you like.
My wife (Thai) and I (American) had our first daughter this year. When she first got pregnant, one of the doc's first priorities was to get us both tested for "Thalassemia", which I had never heard of before. Apparently it is a blood disorder that affects hemoglobin production and therefore red blood cells -- if both parents carry the (rather rare) recessive gene, it can be a pretty bad deal.
It turned out that my wife is in the 1% or so of Thais that carry the gene (but she doesn't express / suffer from it, it is recessive and she has the dominant gene also). I had to get tested as well, but they said it would be incredibly unlikely that I'd be positive and I wasn't. So, our daughter has a 25% chance of being a carrier like my wife but zero chance of suffering from the effects of it.
Anyway, I was curious about the disease and asked the doc why it is a big deal here (every pregnant couple MUST get screened for it here when getting hospital/prenatal care) but I'd never even heard of it in the US. It turns out that the disease / genetic mutation arose only in places with high rates of malaria. As it happens, the genetic effect on your blood cells that the mutation has makes you more resistant to malaria -- full-on exhibitors of it (two recessive genes) are far less likely to die of malaria than people that don't have the gene. That is, assuming that you don't have the extreme variants of it that make it very unlikely to survive early childhood. Basically, if you have the disease and yet are healthy enough to survive to adulthood, you're close to malaria immune (that's overstating it, but ballpark). The malaria parasite can't survive and reproduce properly on your funky Thalassemia-affected red blood cells.
I thought that was a pretty interesting evolutionary response that must have arisen from some populations being pretty much decimated by malaria back in pre-recorded history. Current carriers like my wife are probably the descendants of lucky folks that survived a deadly outbreak in history by virtue of having a disease/mutation that is, under normal circumstances, slightly or even extremely bad in species survival / reproductive fitness terms. I thought that was kinda cool -- but I'm glad that neither my wife nor my daughter are/can be full-on expressors of the gene.
Dinosaurs Died Out Before Man Came Around, Right?
http://en.wikipedia.org/wiki/Dinosaur#Soft_tissue_and_DNA
Read the 4th paragraph. This video is full of quote mining and general bullshit.
Sledgehammer Bomb Day
That is very *EIA .
This is why you do not take those instant cold ICE Packs and bang them around and shit.
You crack the water module, and then shake the liquid down onto the ammonium nitrate pellets.
http://home.howstuffworks.com/refrigerator7.htm
This house hold product is an interesting item, much like non dairy coffee creamer. These are both very dangerous, in the hands of idiots.
http://www.jtbaker.com/msds/englishhtml/a6048.htm
Ammonium Nitrate is an oxidizer, and is very dangerous.
Proof of Creationism!
/\ interesting note, smibbo.
Reminds me of the genetic trait for sickle-shaped red blood cells; millions die from malaria every year, but a simple alteration of the shape of blood cells confers some resistance, making what would generally be a "bad" genetic mutation (less efficient hemoglobin) actually a slight advantage in particular environments (areas with malaria, like the lowlands of central Africa).
(google searched my facts... check!: http://sickle.bwh.harvard.edu/malaria_sickle.html )
Selective pressure is always there, even in human society. Look around! I have friends with slightly different skin color, eye color, hair texture, facial features, hand shapes, head shape, etc., from my own. Recorded history is almost nothing in the scale of time scientific theories often attempt to describe.
Poo Facts
An interesting fact I picked up the other day, just in case you wondered why your shit is typically brown:
The brown colour of feces is due to the action of bacteria on bilirubin, which is the end product of the breakdown of hemoglobin (red blood cells)
Bilirubin is a useless and toxic breakdown product of hemoglobin, which also means that it is generated in large quantities. In the time it takes you to read this sentence aloud, roughly 20 million of your red blood cells have died and roughly 5 quintillion (5 x 1015) molecules of hemoglobin are in need of disposal.
In the liver cells (hepatocytes) the bound bilirubin reacts with glucuronic acid to form conjugated bilirubin. Most of the conjugated bilirubin is secreted into the small intestine with the bile. In the large bowel, bacteria convert bilirubin into the yellow-brown pigment (urobilinogen) that gives feces its characteristic color. Some of this pigment re-enters the blood from the colon and is removed by the kidney into the urine (characteristic color).
Dr Quantum Visits a 2-Dimensional World
Cool. Reminded me of Disney's Amazing Mr. Hemoglobin.