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Does CBD Have Any Value as a Treatment For Health Issues?

Pancreatic Cancer Patient Hassled at Hospital Over Marijuana

C-note (Member Profile)

Angry pedestrian gets instant karma

harlequinn says...

You don't have well thought out opinions. Your examples are very poor.

Failing to avoid getting hit by a car as a pedestrian may or may not be the pedestrian's fault. I could give you literally thousands of examples where it is not the pedestrian's fault (and I bet the statistics show this to be true the majority of the time) but I'll let you Google them yourself.

I sure as hell hope you're a spring chicken because if someone veers off the road at a high enough speed directed at you, you're going to have a hard time getting out of the way.

BTW, I'll let my mates who are still paramedics know to tell any pedestrians injured by cars (or family thereof for the deceased ones) that it was their fault, even when it wasn't.

This one is just for you:

http://www.theage.com.au/victoria/live-pedestrians-hit-gunshots-heard-in-melbourne-cbd-20170120-gtvf3x.html

http://www.theage.com.au/victoria/melbourne-cbd-horror-four-dead-bourke-street-mall-closed-as-city-reels-after-car-mows-down-pedestrians-20170120-gtvx
3c.html

Payback said:

People walking out in front of cars and getting creamed because of their idiotic belief that simply being right makes them indestructible?

That's hill-AIR-ee-us. E. I. A.

Crash your car into a tree? That's 100% your fail.
Crash your car into a pedestrian? That's 100% your fail.
Fail to avoid getting hit by a car as a pedestrian? THAT is YOUR fail.

Severe Parkinson's Disease before and after using Cannabis

SFOGuy says...

There are CBD (cannaboid) strains with very low THC (the "high" component, mostly) that don't get someone as high---bred for medical use.

Also---very nice video.

Dr. Gupta thinks denying Medicinal Marijuana is Immoral

poolcleaner says...

My migraines aren't in remission but I don't suffer nearly as long as I used to since using light psychoactive CBD/THC. Duration of intense pain, loss of vision, loss of feeling in limbs, nausea, vomiting, and the rare seizure has been reduced from 6-12 hours every 2-4 weeks to maybe 2 hours every couple months, sometimes only with nausea, loss of vision, and minor or no pain.

However, the loss of vision, or what my doctors have referred to as visual "premonitions" are still a major pain that I'm not certain will ever go away. Luckily I don't get very many migraines any more. However, if I do get a migraine I still cannot drive or do anything that requires sight. Although I can technically see, it's severely impaired.

The absence or dulling of the pain during a migraine is the greatest thing that has ever happened to me medically. I had a migraine 2 days ago while I was jogging at the park, ran to my car so I could quickly get home before my vision was fucked, and then placed a soluble CBD + THC tablet (Trokie) up into the corner of my mouth where it was slowly absorbed into the facial branches of my carotid artery. After my vision cleared up, I had no headache.

Keep in mind I also take a pure CBD tablet every couple days, so it's not just the one tablet during episodes.

Brittany Maynard - Death with Dignity

Sniper007 says...

TONS of things cure cancer. All day, every day. Doctors have no clue what cancer is. All they can do is cut, burn, or poison and cross their fingers.

I didn't say Cannabis was THE cure. It is A cure used by thousands with amazing efficacy. Everyone is different.

Here's 60+ studies for your perusal if you insist on the superiority of western scientific research:

"Cannabis, and the cannabinoid compounds found within it, has been shown through a large cannabisplantamount of scientific, peer-reviewed research to be effective at treating a wide variety of cancers, ranging from brain cancer to colon cancer. Below is a list of over 60 studies that demonstrate the vast anti-cancer properties of cannabis.
Studies showing cannabis may combat brain cancer:
Cannabidiol (CBD) inhibits the proliferation and invasion in U87-MG and T98G glioma cells. Study published in the Public Library of Science journal in October 2013.
Tetrahydrocannabinol (THC) can kill cancer cells by causing them to self-digest. Study published in the Journal of Clinical Investigation in September 2013.
CBD is a novel therapeutic target against glioblastoma. Study published in Cancer Research in March 2013.
Local delivery of cannabinoid-filled microparticles inhibits tumor growth in a model of glioblastoma multiforme. Study published in Public Library of Science in January 2013.
Cannabinoid action inhibits the growth of malignant human glioma U87MG cells. Study published in Oncology Reports in July 2012.
Cannabidiol enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival. Study published in the Molecular Cancer Therapeutics journal in January 2010.
Cannabinoid action induces autophagy-mediated cell death in human glioma cells. Study published in The Journal of Clinical Investigation in May 2009.
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Study published in Cancer Research in March 2008.
Cannabinoids and gliomas. Study published in Molecular Neurobiology in June 2007.
Cannabinoids inhibit gliomagenesis. Study published in the Journal of Biological Chemistry in March 2007.
A pilot clinical study of THC in patients with recurrent glioblastoma multiforme. The results were published in the British Journal of Cancer in June 2006.
Cannabidiol inhibits human glioma cell migration through an independent cannabinoid receptor mechanism. Study published in the British Journal of Pharmacology in April 2005.
Cannabinoids inhibit the vascular endothelial growth factor pathway (VEGF) in gliomas. Study published in the Journal of Cancer Research in August 2004.
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. Study published in the Journal of Pharmacology in November 2003.
Inhibition of glioma growth in vivo by selective activation of the CB2 cannabinoid receptor. Study published in the Journal of Cancer Research in August 2001.
Studies showing cannabis may combat colorectal cancer:
Cannabigerol (CBG) can inhibit colon cancer cells. Study published in the Oxford journal Carcinogenesis in October 2014.
Inhibition of colon carcinogenesis by a standardised Cannabis Sativa extract with high content of CBD. Study published in Phytomedecine in December 2013.
Chemopreventive effect of the non-psychotropic phytocannabinoid CBD on colon cancer. Study published in the Journal of Molecular Medecine in August 2012.
Cannabinoids against intestinal inflammation and cancer. Study published in Pharmacology Research in August 2009.
Action of cannabinoid receptors on colorectal tumor growth. Study published by the Cancer Center of the University of Texas in July 2008.
Studies showing cannabis may combat blood cancer:
The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. Study published in the International Journal of Cancer in December 2013.
Enhancing the activity of CBD and other cannabinoids against leukaemia. Study published in Anticancer Research in October 2013.
Cannabis extract treatment for terminal acute lymphoblastic leukemia of Philadelphia chromosome (Ph1). Study published in Case Reports in Oncology in September 2013.
Expression of type 1 and type 2 cannabinoid receptors in lymphoma. Study published in the International Journal of Cancer in June 2008.
Cannabinoid action in mantle cell lymphoma. Study published in Molecular Pharmacology in November 2006.
THC-induced apoptosis in Jurkat leukemia. Study published in Molecular Cancer Research in August 2006.
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Study published in Blood American Society of Hemmatology in July 2002.
Studies showing cannabis can combat lung cancer:
Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of Icam-1. Study published in Biochemical Pharmacology in July 2014.
Cannabinoids inhibit angiogenic capacities of endothelial cells via release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells. Study published in Biochemical Pharmacology in June 2014.
COX-2 and PPAR-γ confer CBD-induced apoptosis of human lung cancer cells. Study published in Molecular Cancer Therapeutics in January 2013.
CBD inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. Study published in the Journal of the Federation of American Societies for Experimental Biology in April 2012.
Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non–small cell lung cancer growth and metastasis. Study published in Cancer Prevention Research in January 2011.
THC inhibits epithelial growth factor-induced (EGF) lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Study published in the journal Oncogene in July 2007.
Studies showing cannabis may combat stomach cancer:
Cannabinoid receptor agonist as an alternative drug in 5-Fluorouracil-resistant gastric cancer cells. Study published in Anticancer Research in June 2013.
Antiproliferative mechanism of a cannabinoid agonist by cell cycle arrest in human gastric cancer cells. Study published in the Journal of Cellular Biochemistry in March 2011.
Studies showing cannabis may combat prostrate cancer:
Cannabinoids can treat prostate cancer. Study published by the National Institute of Health in October 2013.
Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms. Study published in the British Journal of Pharmacology in December 2012.
The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications. Study published in the Indian Journal of Urology in January 2012.
Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent. Study published in Anticancer Research in November 2011.
Studies showing cannabis may combat liver cancer:
Involvement of PPARγ in the antitumoral action of cannabinoids on hepatocellular carcinoma (CHC). Study published in Cell Death and Disease in May 2013.
Evaluation of anti-invasion effect of cannabinoids on human hepatocarcinoma cells. Study published on the site Informa Healthcare in February 2013.
Antitumoral action of cannabinoids on hepatocellular carcinoma. Study published in Cell Death and Differentiation in April 2011.
Studies showing cannabis may combat pancreatic cancer:
Cannabinoids inhibit energetic metabolism and induce autophagy in pancreatic cancer cells. Study published in Cell Death and Disease in June 2013.
Cannabinoids Induce apoptosis of pancreatic tumor cells. Study published in Cancer Research in July 2006.
Studies showing cannabis may combat skin cancer:
Cannabinoid receptor activiation can combat skin cancer. Study published by the National Institute of Health in October 2013.
Cannabinoids were found to reduce skin cancer by 90% in just 2 weeks. Study published in the Journal of Pharmacy and Pharmacology in July 2013.
Cannabinoid receptors as novel targets for the treatment of melanoma. Study published in the Journal of the Federation of American Societies for Experimental Biology in December 2006.
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. Study published in the Journal of Clinical Investigation, in January 2003.
Studies showing cannabis may combat other types of cancer:
Bladder: Marijuana reduces the risk of bladder cancer. Study published in the Medscape site in May 2013.
Kaposi sarcoma: Cannabidiol inhibits growth and induces programmed cell death in Kaposi sarcoma–associated herpesvirus-infected endothelium. Study published in the journal Genes & Cancer in July 2012.
Nose, mouth, throat, ear: Cannabinoids like THC inhibit cellular respiration of human oral cancer cells. Study by the Department of Pediatrics at the State University of New York, published in June 2010.
Bile duct: The dual effects of THC on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration. Study published in Cancer Investigation in May 2010.
Ovaries: Cannabinoid receptors as a target for therapy of ovarian cancer. Study published on the American Association for Cancer Research website in 2006.
Preparation and characterisation of biodegradable microparticles filled with THC and their antitumor efficacy on cancer cell lines. Study published in the Journal of Drug Targeting in September 2013.
CBD Cannabidiol as a potential anticancer drug. Study published in the British Journal of Pharmacology in February 2013.
Cannabinoids as anticancer modulators. Study published in the Progress in Lipid Research journal in January 2013.
CBD inhibits angiogenesis by multiple mechanisms. Study published in the British Journal of Pharmacology in November 2012.
Towards the use of cannabinoids as antitumour agents. Study published in Nature in June 2012.
Cannabinoid-associated cell death mechanisms in tumor models. Study published in the International Journal of Oncology in May 2012.
Cannabinoids, endocannabinoids and cancer. Study published in Cancer Metastasis Reviews in December 2011.
The endocannabinoid system and cancer: therapeutic implication. Study published in the British Journal of Pharmacology in July 2011.
This list was compiled in part by Alchimiaweb.com.
– TheJointBlog"

ChaosEngine said:

No, you'd be remiss if you opined blatant misinformation.

While there is a possibility that cannabinoids can inhibit tumour growth, there is nothing even close to a solid evidence base to show that "cannabis cures cancer".

Dr Sanjay Gupta's CNN Special "WEED"

vaire2ube says...

CBD possesses sedative properties (Carlini and Cunha, 1981), and a clinical
trial showed that it reduces the anxiety and other unpleasant psychological
side effects provoked by pure THC (Zuardi et al. 1982). CBD modulates the
pharmacokinetics of THC by three mechanisms: (1) it has a slight affinity for
cannabinoid receptors (Ki at CB1 = 4350 nM, compared to THC = 41 nM,
Showalter et al. 1996), and it signals receptors as an antagonist or reverse agonist
(Petitet et al. 1998), (2) CBD may modulate signal transduction by perturbing
the fluidity of neuronal membranes, or by remodeling G-proteins that
carry intracellular signals downstream from cannabinoid receptors, and (3)CBD
is a potent inhibitor of cytochrome P450 3A11 metabolism, thus it blocks the
hydroxylation of THC to its 11-hydroxy metabolite (Bornheim et al. 1995).
The 11-hydroxy metabolite is four times more psychoactive than unmetabolized
THC (Browne and Weissman 1981), and four times more immunosuppressive
(Klein et al. 1987).
CBD provides antipsychotic benefits (Zuardi et al. 1995). It increases dopamine
activity, serves as a serotonin uptake inhibitor, and enhances norepinephrine
activity (Banerjee et al. 1975; Poddar and Dewey 1980). CBD protects
neurons from glutamate toxicity and serves as an antioxidant, more potently
than ascorbate and α-tocopherol (Hampson et al. 1998). Auspiciously, CBD
does not decrease acetylcholine (ACh) activity in the brain (Domino 1976;
Cheney et al. 1981). THC, in contrast, reduces hippocampal ACh release in
rats (Carta et al. 1998), and this correlates with loss of short-term memory consolidation.
In the hippocampus THC also inhibits N-methyl-D-aspartate (NMDA)
receptor activity (Misner and Sullivan 1999; Shen and Thayer 1999), and
NMDA synaptic transmission is crucial for memory consolidation (Shimizu et
al. 2000). CBD, unlike THC, does not dampen the firing of hippocampal cells
(Heyser et al. 1993) and does not disrupt learning (Brodkin and Moerschbaecher
1997).
Consroe (1998) presented an excellent review of CBD in neurological disorders.
In some studies, it ameliorates symptoms of Huntington’s disease, such
as dystonia and dyskinesia. CBD mitigates other dystonic conditions, such as
torticollis, in rat studies and uncontrolled human studies. CBD functions as an
anticonvulsant in rats, on a par with phenytoin (Dilantin, a standard antiepileptic
drug).
CBD demonstrated a synergistic benefit in the reduction of intestinal motility
in mice produced by THC (Anderson, Jackson, and Chesher 1974). This
may be an important component of observed benefits of cannabis in inflammatory
bowel diseases.

--"Cannabis and Cannabis Extracts:
Greater Than the Sum of Their Parts?
John M. McPartland
Ethan B. Russo"

Dr Sanjay Gupta's CNN Special "WEED"

vaire2ube says...

naw, unlike most "drugs" that ruin lives as a property of their chemical interactions, cannabis is completely safe.

the only thing that will cause harm is exacerbating an existing medical condition that is prone to the hypertension, or actions taken while in an "unsafe" setting like toking up the first time while driving.

hardly a reason to worry about it, most therepeutically safe substance known to mankind, as well as the fact that even if medical use isnt the reason, recreational use with properly informed persons will result in no harm and possible benefit.

even if people started using it at the volume and frequency of alcohol, their lives would actually be made better because of the effects of the plant.

infuriating but the truth is finally coming out. the US has a patent on CBD since 2003 through the dept of health and human services for its antiinflammatory effects. .. and no one even knows about CBD, even really educated people who have the internet. its fucked up. See the TED sift about willful ignorance.

when it becomes easier to be informed then not, we will see a change. thats fucked up, but whatever im not like that. ill keep trying.

Dr Sanjay Gupta's CNN Special "WEED"

Mekanikal says...

A buddy of mine runs a collective and tries to get the highest CBD on certain strains. He said there's a lot of red tape involved in getting it properly tested and that there are several different CBD types, each targeting a different part of the body.

Dr Apologizes for Being SO WRONG About Medical Marijuana

vaire2ube says...

and now the articles in the news focus on THC content, yet again.

There is a PHd chemistry professor at my school, young guy, who didnt even know cannabidiol was from cannabis. CBD. You know, the anti cancer neuroprotectant miracle drug?

Yea. Current research and the US PATENT on the substance say we have been misled. Where is gupta on this EASY to find information?

FUck.

Please spread the word. The sin of omission is the greatest of all.

luxury apartment in Ho Chi Minh, luxury apartment in sai gon

Man Calls JPMorgan Chase CEO A Crook To His Face

kevingrr says...

@bmacs27

No doubt, the best deals get done. The two I have in mind as examples are either under construction or fully built. When you have firm tenant commitments with specific requirements there is money out there that will back the project. In one case an institutional investor partnered with the developer to fund the project. In the other the developers got cash from just about everywhere and anywhere they could to meet the equity requirement.

What happened in my market is a "flight to quality" or "flight to safety". Basically tenants and developers stopped looking at the green belt (developing outer edges) and started looking at the strongest parts of the local market. That means the CBD and established communities. These deals are harder, but they are safer. Thus the "easy" deals in the developing (speculative) communities ended.

The idea that there are a bunch of empty shopping malls isn't really true. Vacancy rates spiked several years ago yes, but since then the amount of new space to market (supply) has dropped.


When I recently surveyed four communities in Central, IL (Bloomington/Normal, Springfield, Decatur, & Champaign/Urbana) I found that there is very little available retail space. Same goes for the Chicago Loop.

I agree we need infrastructure investment but we also need let the market dictate where new construction is going to take place because each market is different. Location location location. If the fundamentals make sense we need to build.

Melbourne Siftup (with Dag): This Saturday! (Downunder Talk Post)

kymbos says...

Yep, it's all looking good. Saturday's now looking 25 and mostly sunny - loving it.

Melbourne is our oyster. I have had a bit of a check, and most rooftop bars open around midday on Saturday.

http://www.au.timeout.com/melbourne/bars/venues/725/campari-house
http://www.au.timeout.com/melbourne/bars/venues/412/rooftop-bar
http://rooftopcinema.com.au/
http://www.urbanspoon.com/r/71/1621007/restaurant/CBD/The-Aylesbury-Melbourne
http://www.theage.com.au/entertainment/restaurants-and-bars/the-aylesbury-20111029-1mpah.html

As I said, I'm looking like 8pm and will contact Dag to find your whereabouts. If you do head to the rooftops, Mme Brussels and the Carlton Hotel are pretty close by Meyers Place. Brussels is a bit more showy and expensive than the Carlton, which is more of a 'beer on tap' kind of place. The rooftop bar on Swanston St is further away, but has a spectacular view.

If you are keen to eat before I get there, no worries - I'll meet you for drinks afters.

Melbourne Siftup (with Dag): This Saturday! (Downunder Talk Post)



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